Toxicological Sciences

Toxicological Highlight:

Richard F. Seegal

The Neurotoxicological Consequences of Developmental Exposure to PCBs
Toxicol. Sci. 2000 57: 1-3; doi:10.1093/toxsci/57.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Profiles in Toxicology:

John H. Weisburger and Gary M. Williams

The Distinction between Genotoxic and Epigenetic Carcinogens and Implication for Cancer Risk
Toxicol. Sci. 2000 57: 4-5; doi:10.1093/toxsci/57.1.4 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

James P. Kehrer and Shyam S. Biswal

The Molecular Effects of Acrolein
Toxicol. Sci. 2000 57: 6-15; doi:10.1093/toxsci/57.1.6 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

I. Petrikovics, T.-C. Cheng, D. Papahadjopoulos, K. Hong, R. Yin, J. J. DeFrank, J. Jaing, Z. H. Song, W. D. McGuinn, D. Sylvester, L. Pei, J. Madec, C. Tamulinas, J. C. Jaszberenyi, T. Barcza, and J. L. Way

Long Circulating Liposomes Encapsulating Organophosphorus Acid Anhydrolase in Diisopropylfluorophosphate Antagonism
Toxicol. Sci. 2000 57: 16-21; doi:10.1093/toxsci/57.1.16 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zoltán Gregus, Ágnes Gyurasics, and Iván Csanaky

Effects of Arsenic-, Platinum-, and Gold-Containing Drugs on the Disposition of Exogenous Selenium in Rats
Toxicol. Sci. 2000 57: 22-31; doi:10.1093/toxsci/57.1.22 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Marie Haag-Grönlund, Rory Conolly, Gunilla Scheu, Lars Wärngård, and Ronny Fransson-Steen

Analysis of Rat Liver Foci Growth with a Quantitative Two-Cell Model after Treatment with 2,4,5,3',4'-Pentachlorobiphenyl
Toxicol. Sci. 2000 57: 32-42; doi:10.1093/toxsci/57.1.32 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Karol L. Thompson, Barry A. Rosenzweig, Yi Tsong, and Frank D. Sistare

Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay
Toxicol. Sci. 2000 57: 43-53; doi:10.1093/toxsci/57.1.43 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

Koichi Saito, Yoshitaka Tomigahara, Norihisa Ohe, Naohiko Isobe, Iwao Nakatsuka, and Hideo Kaneko

Lack of Significant Estrogenic or Antiestrogenic Activity of Pyrethroid Insecticides in Three in Vitro Assays Based on Classic Estrogen Receptor -Mediated Mechanisms
Toxicol. Sci. 2000 57: 54-60; doi:10.1093/toxsci/57.1.54 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joseph C. Siglin, David R. Mattie, Darol E. Dodd, Paul K. Hildebrandt, and William H. Baker

A 90-Day Drinking Water Toxicity Study in Rats of the Environmental Contaminant Ammonium Perchlorate
Toxicol. Sci. 2000 57: 61-74; doi:10.1093/toxsci/57.1.61 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

C.-L. J. Li and M. O. James

Oral Bioavailability and Pharmacokinetics of Elimination of 9-Hydroxybenzo[a]pyrene and Its Glucoside and Sulfate Conjugates after Administration to Male and Female American Lobsters, Homarus americanus
Toxicol. Sci. 2000 57: 75-86; doi:10.1093/toxsci/57.1.75 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

Jennifer E. Snyder, Nikolay M. Filipov, Patrick J. Parsons, and David A. Lawrence

The Efficiency of Maternal Transfer of Lead and Its Influence on Plasma IgE and Splenic Cellularity of Mice
Toxicol. Sci. 2000 57: 87-94; doi:10.1093/toxsci/57.1.87 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

Zengjun Xu, Louis W. Chang, William Slikker, Jr., Syed F. Ali, Robert L. Rountree, and Andrew C. Scallet

A Dose-Response Study of Ibogaine-Induced Neuropathology in the Rat Cerebellum
Toxicol. Sci. 2000 57: 95-101; doi:10.1093/toxsci/57.1.95 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. E. Gilbert, W. R. Mundy, and K. M. Crofton

Spatial Learning and Long-Term Potentiation in the Dentate Gyrus of the Hippocampus in Animals Developmentally Exposed to Aroclor 1254
Toxicol. Sci. 2000 57: 102-111; doi:10.1093/toxsci/57.1.102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wasiuddin A. Khan, Anjelika M. Dechkovskaia, Elizabeth A. Herrick, Katherine H. Jones, and Mohamed B. Abou-Donia

Acute Sarin Exposure Causes Differential Regulation of Choline Acetyltransferase, Acetylcholinesterase, and Acetylcholine Receptors in the Central Nervous System of the Rat
Toxicol. Sci. 2000 57: 112-120; doi:10.1093/toxsci/57.1.112 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cindy S. Roegge, Byung-Woun Seo, Kevin M. Crofton, and Susan L. Schantz

Gestational-Lactational Exposure to Aroclor 1254 Impairs Radial-Arm Maze Performance in Male Rats
Toxicol. Sci. 2000 57: 121-130; doi:10.1093/toxsci/57.1.121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. M. Crofton, P. R. S. Kodavanti, E. C. Derr-Yellin, A. C. Casey, and L. S. Kehn

PCBs, Thyroid Hormones, and Ototoxicity in Rats: Cross-Fostering Experiments Demonstrate the Impact of Postnatal Lactation Exposure
Toxicol. Sci. 2000 57: 131-140; doi:10.1093/toxsci/57.1.131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Sally A. Thompson, Collin C. White, Cecile M. Krejsa, David L. Eaton, and Terrance J. Kavanagh

Modulation of Glutathione and Glutamate-L-cysteine Ligase by Methylmercury during Mouse Development
Toxicol. Sci. 2000 57: 141-146; doi:10.1093/toxsci/57.1.141 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tracy M. Williams and Susan J. Borghoff

Induction of Testosterone Biotransformation Enzymes following Oral Administration of Methyl tert-Butyl Ether to Male Sprague-Dawley Rats
Toxicol. Sci. 2000 57: 147-155; doi:10.1093/toxsci/57.1.147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Sang-Hee Jeong, Sultan S. M. Habeebu, and Curtis D. Klaassen

Cadmium Decreases Gap Junctional Intercellular Communication in Mouse Liver
Toxicol. Sci. 2000 57: 156-166; doi:10.1093/toxsci/57.1.156 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yaping Liu, Jie Liu, Sultan M. Habeebu, Michael P. Waalkes, and Curtis D. Klaassen

Metallothionein-I/II Null Mice Are Sensitive to Chronic Oral Cadmium-Induced Nephrotoxicity
Toxicol. Sci. 2000 57: 167-176; doi:10.1093/toxsci/57.1.167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anabela P. Rolo, Paulo J. Oliveira, António J. M. Moreno, and Carlos M. Palmeira

Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy
Toxicol. Sci. 2000 57: 177-185; doi:10.1093/toxsci/57.1.177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Letters to the Editor:

James Huff and Lorenzo Tomatis

Letters to the Editor
Toxicol. Sci. 2000 57: 186; doi:10.1093/toxsci/57.1.186 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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