Toxicological Sciences

Toxicological Highlight:

Torka S. Poet

Assessing Dermal Absorption
Toxicol. Sci. 2000 58: 1-2; doi:10.1093/toxsci/58.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Profiles in Toxicology:

Robert Snyder

Cytochrome P450, the Oxygen-Activating Enzyme in Xenobiotic Metabolism
Toxicol. Sci. 2000 58: 3-4; doi:10.1093/toxsci/58.1.3 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

Mark Toraason, Gordon Sussman, Raymond Biagini, Jean Meade, Donald Beezhold, and Dori Germolec

Latex Allergy in the Workplace
Toxicol. Sci. 2000 58: 5-14; doi:10.1093/toxsci/58.1.5 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Johannes J. M. van de Sandt, Wim J. A. Meuling, Graham R. Elliott, Nicole H. P. Cnubben, and Betty C. Hakkert

Comparative in Vitro–in Vivo Percutaneous Absorption of the Pesticide Propoxur
Toxicol. Sci. 2000 58: 15-22; doi:10.1093/toxsci/58.1.15 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephanie L. Born, Douglas Caudill, Bill J. Smith, and Lois D. Lehman-McKeeman

In Vitro Kinetics of Coumarin 3,4-Epoxidation: Application to Species Differences in Toxicity and Carcinogenicity
Toxicol. Sci. 2000 58: 23-31; doi:10.1093/toxsci/58.1.23 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

N. Christine Halmes, Stephen M. Roberts, J. Keith Tolson, and Christopher J. Portier

Reevaluating Cancer Risk Estimates for Short-Term Exposure Scenarios
Toxicol. Sci. 2000 58: 32-42; doi:10.1093/toxsci/58.1.32 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kunitoshi Mitsumori, Takeo Shimo, Hiroshi Onodera, Hisayoshi Takagi, Kazuo Yasuhara, Toru Tamura, Yasuji Aoki, Osamu Nagata, and Masao Hirose

Modifying Effects of Ethinylestradiol but Not Methoxychlor on N-Ethyl-N-nitrosourea-Induced Uterine Carcinogenesis in Heterozygous p53-Deficient CBA Mice
Toxicol. Sci. 2000 58: 43-49; doi:10.1093/toxsci/58.1.43 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

T. E. Stoker, S. C. Laws, D. L. Guidici, and R. L. Cooper

The Effect of Atrazine on Puberty in Male Wistar Rats: An Evaluation in the Protocol for the Assessment of Pubertal Development and Thyroid Function
Toxicol. Sci. 2000 58: 50-59; doi:10.1093/toxsci/58.1.50 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

Timo Hamers, Kim R. J. Molin, Jan H. Koeman, and Albertinka J. Murk

A Small-Volume Bioassay for Quantification of the Esterase Inhibiting Potency of Mixtures of Organophosphate and Carbamate Insecticides in Rainwater: Development and Optimization
Toxicol. Sci. 2000 58: 60-67; doi:10.1093/toxsci/58.1.60 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kristine L. Willett, Piero R. Gardinali, Laila A. Lienesch, and Richard T. Di Giulio

Comparative Metabolism and Excretion of Benzo(a)pyrene in 2 Species of Ictalurid Catfish
Toxicol. Sci. 2000 58: 68-76; doi:10.1093/toxsci/58.1.68 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

Stephen B. Pruett, Ruping Fan, Qiang Zheng, L. Peyton Myers, and Pamela Hébert

Modeling and Predicting Selected Immunological Effects of a Chemical Stressor (3,4-Dichloropropionanilide) Using the Area under the Corticosterone Concentration versus Time Curve
Toxicol. Sci. 2000 58: 77-87; doi:10.1093/toxsci/58.1.77 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

T. S. Thurmond and T. A. Gasiewicz

A Single Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Produces a Time- and Dose-Dependent Alteration in the Murine Bone Marrow B-Lymphocyte Maturation Profile
Toxicol. Sci. 2000 58: 88-95; doi:10.1093/toxsci/58.1.88 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

L. Gribaldo, I. Malerba, A. Collotta, S. Casati, and A. Pessina

Inhibition of CFU-E/BFU-E by 3'-Azido-3'-deoxythymidine, Chlorpropamide, and Protoporphirin IX Zinc (II): A Comparison between Direct Exposure of Progenitor Cells and Long-Term Exposure of Bone Marrow Cultures
Toxicol. Sci. 2000 58: 96-101; doi:10.1093/toxsci/58.1.96 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

B. Z. Zhong and P. D. Siegel

Induction of Micronuclei following Exposure to Methylene Di-phenyl Diisocyanate: Potential Genotoxic Metabolites
Toxicol. Sci. 2000 58: 102-108; doi:10.1093/toxsci/58.1.102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mary Lynn Bajt, Judy A. Lawson, Steven L. Vonderfecht, Jaspreet S. Gujral, and Hartmut Jaeschke

Protection against Fas Receptor–Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial Processing of Caspase-8
Toxicol. Sci. 2000 58: 109-117; doi:10.1093/toxsci/58.1.109 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

Stacey A. Kardos and Lester G. Sultatos

Interactions of the Organophosphates Paraoxon and Methyl Paraoxon with Mouse Brain Acetylcholinesterase
Toxicol. Sci. 2000 58: 118-126; doi:10.1093/toxsci/58.1.118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mads Skak Jensen, Niels Chresten Berg Nyborg, and Erling Sonnich Thomsen

Various Nitric Oxide Donors Protect Chick Embryonic Neurons from Cyanide-Induced Apoptosis
Toxicol. Sci. 2000 58: 127-134; doi:10.1093/toxsci/58.1.127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

A. M. Cummings, B. E. Rhodes, and R. L. Cooper

Effect of Atrazine on Implantation and Early Pregnancy in 4 Strains of Rats
Toxicol. Sci. 2000 58: 135-143; doi:10.1093/toxsci/58.1.135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa A. Cotter, Deidre L. Policz, Gerald Pöch, and Douglas A. Dawson

Analysis of the Combined Osteolathyritic Effects of ß-Aminopropionitrile and Diethyldithiocarbamate on Xenopus Development
Toxicol. Sci. 2000 58: 144-152; doi:10.1093/toxsci/58.1.144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

S. Rappeneau, A. Baeza-Squiban, F. Marano, and J.-H. Calvet

Efficient Protection of Human Bronchial Epithelial Cells against Sulfur and Nitrogen Mustard Cytotoxicity Using Drug Combinations
Toxicol. Sci. 2000 58: 153-160; doi:10.1093/toxsci/58.1.153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. J. Boogaard, K. P. de Kloe, S. C. J. Sumner, P. A. van Elburg, and B. A. Wong

Disposition of [Ring-U-¹⁴C]styrene in Rats and Mice Exposed by Recirculating Nose-Only Inhalation
Toxicol. Sci. 2000 58: 161-172; doi:10.1093/toxsci/58.1.161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jürgen Pauluhn

Inhalation Toxicity of 1,6-Hexamethylene Diisocyanate Homopolymer (HDI-IC) Aerosol: Results of Single Inhalation Exposure Studies
Toxicol. Sci. 2000 58: 173-181; doi:10.1093/toxsci/58.1.173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel L. Morgan, Herman C. Price, Robert W. O'Connor, John C. Seely, Sandra M. Ward, Ralph E. Wilson, and Michael C. Cunningham

Upper Respiratory Tract Toxicity of Inhaled Methylvinyl Ketone in F344 Rats and B6C3F1 Mice
Toxicol. Sci. 2000 58: 182-194; doi:10.1093/toxsci/58.1.182 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Marie-Françoise Hubert, Philippe Laroque, Jean-Pierre Gillet, and Kevin P. Keenan

The Effects of Diet, ad Libitum Feeding, and Moderate and Severe Dietary Restriction on Body Weight, Survival, Clinical Pathology Parameters, and Cause of Death in Control Sprague-Dawley Rats
Toxicol. Sci. 2000 58: 195-207; doi:10.1093/toxsci/58.1.195 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

C. Charles Barton, Patricia E. Ganey, and Robert A. Roth

Lipopolysaccharide Augments Aflatoxin B₁-Induced Liver Injury through Neutrophil-Dependent and -Independent Mechanisms
Toxicol. Sci. 2000 58: 208-215; doi:10.1093/toxsci/58.1.208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Errata:

Erratum
Toxicol. Sci. 2000 58: 0; doi:10.1093/toxsci/58.1.0 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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