Toxicological Sciences

Toxicological Highlight:

Brian M. Freed, Yanli Ouyang, and Jesica M. McCue

Mechanisms of Altered Transcription by Cigarette Smoke
Toxicol. Sci. 2001 59: 1-2; doi:10.1093/toxsci/59.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Profiles In Toxicology:

Martin K. Johnson

W. Norman Aldridge
Toxicol. Sci. 2001 59: 3-4; doi:10.1093/toxsci/59.1.3 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

Barry Weinberger, Debra L. Laskin, Diane E. Heck, and Jeffrey D. Laskin

The Toxicology of Inhaled Nitric Oxide
Toxicol. Sci. 2001 59: 5-16; doi:10.1093/toxsci/59.1.5 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James T. MacGregor, Jerry M. Collins, Yuichi Sugiyama, Charles A. Tyson, Jack Dean, Lewis Smith, Melvin Andersen, Rodger D. Curren, J. Brian Houston, Fred F. Kadlubar, Gregory L. Kedderis, Kannan Krishnan, Albert P. Li, Ralph E. Parchment, Kenneth Thummel, Joseph E. Tomaszewski, Roger Ulrich, Alison E. M. Vickers, and Steven A. Wrighton

In Vitro Human Tissue Models in Risk Assessment: Report of a Consensus-Building Workshop
Toxicol. Sci. 2001 59: 17-36; doi:10.1093/toxsci/59.1.17 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Christopher Lau, M. Leonard Mole, M. Frank Copeland, John M. Rogers, Robert J. Kavlock, Dana L. Shuey, Annie M. Cameron, David H. Ellis, Tina R. Logsdon, Jennifer Merriman, and R. Woodrow Setzer

Toward a Biologically Based Dose-Response Model for Developmental Toxicity of 5-Fluorouracil in the Rat: Acquisition of Experimental Data
Toxicol. Sci. 2001 59: 37-48; doi:10.1093/toxsci/59.1.37 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Woodrow Setzer, Christopher Lau, M. Leonard Mole, M. Frank Copeland, John M. Rogers, and Robert J. Kavlock

Toward a Biologically Based Dose-Response Model for Developmental Toxicity of 5-Fluorouracil in the Rat: A Mathematical Construct
Toxicol. Sci. 2001 59: 49-58; doi:10.1093/toxsci/59.1.49 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Herbert Zepnik, Axel Pähler, Ute Schauer, and Wolfgang Dekant

Ochratoxin A-Induced Tumor Formation: Is There a Role of Reactive Ochratoxin A Metabolites?
Toxicol. Sci. 2001 59: 59-67; doi:10.1093/toxsci/59.1.59 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Samuel M. Cohen, Shinji Yamamoto, Marty Cano, and Lora L. Arnold

Urothelial Cytotoxicity and Regeneration Induced by Dimethylarsinic Acid in Rats
Toxicol. Sci. 2001 59: 68-74; doi:10.1093/toxsci/59.1.68 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephan Gebel and Thomas Müller

The Activity of NF-B in Swiss 3T3 Cells Exposed to Aqueous Extracts of Cigarette Smoke Is Dependent on Thioredoxin
Toxicol. Sci. 2001 59: 75-81; doi:10.1093/toxsci/59.1.75 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Paul Titis and Poh-Gek Forkert

Strain-Related Differences in Bioactivation of Vinyl Carbamate and Formation of DNA Adducts in Lungs of A/J, CD-1, and C57BL/6 Mice
Toxicol. Sci. 2001 59: 82-91; doi:10.1093/toxsci/59.1.82 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

Simone A. van der Plas, Ineke Lutkeschipholt, Bert Spenkelink, and Abraham Brouwer

Effects of Subchronic Exposure to Complex Mixtures of Dioxin-like and Non-Dioxin-like Polyhalogenated Aromatic Compounds on Thyroid Hormone and Vitamin A Levels in Female Sprague-Dawley Rats
Toxicol. Sci. 2001 59: 92-100; doi:10.1093/toxsci/59.1.92 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

R. A. Butler and G. Roesijadi

Disruption of Metallothionein Expression with Antisense Oligonucleotides Abolishes Protection Against Cadmium Cytotoxicity in Molluscan Hemocytes
Toxicol. Sci. 2001 59: 101-107; doi:10.1093/toxsci/59.1.101 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

Shu-Hai Huang, Ann F. Hubbs, Charles F. Stanley, Val Vallyathan, Peter C. Schnabel, Yongyut Rojanasakul, Joseph K. H. Ma, Daniel E. Banks, and David N. Weissman

Immunoglobulin Responses to Experimental Silicosis
Toxicol. Sci. 2001 59: 108-117; doi:10.1093/toxsci/59.1.108 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

Evan P. Gallagher and Karen M. Sheehy

Effects of Phenytoin on Glutathione Status and Oxidative Stress Biomarker Gene mRNA Levels in Cultured Precision Human Liver Slices
Toxicol. Sci. 2001 59: 118-126; doi:10.1093/toxsci/59.1.118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

Parikshit C. Das, William K. McElroy, and Ralph L. Cooper

Alteration of Catecholamines in Pheochromocytoma (PC12) Cells in Vitro by the Metabolites of Chlorotriazine Herbicide
Toxicol. Sci. 2001 59: 127-137; doi:10.1093/toxsci/59.1.127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

B. S. Winder, C. S. Strandgaard, and M. G. Miller

The Role of GTP Binding and Microtubule-Associated Proteins in the Inhibition of Microtubule Assembly by Carbendazim
Toxicol. Sci. 2001 59: 138-146; doi:10.1093/toxsci/59.1.138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sherry E. Rier, Wayman E. Turner, Dan C. Martin, Richard Morris, George W. Lucier, and George C. Clark

Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis
Toxicol. Sci. 2001 59: 147-159; doi:10.1093/toxsci/59.1.147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Steve K. Teo, Mark G. Evans, Mark J. Brockman, Julie Ehrhart, J. Michael Morgan, David I. Stirling, and Steve D. Thomas

Safety Profile of Thalidomide after 53 Weeks of Oral Administration in Beagle Dogs
Toxicol. Sci. 2001 59: 160-168; doi:10.1093/toxsci/59.1.160 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Akiko Enomoto, Ken Itoh, Eiko Nagayoshi, Junko Haruta, Toyoe Kimura, Tania O'Connor, Takanori Harada, and Masayuki Yamamoto

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes
Toxicol. Sci. 2001 59: 169-177; doi:10.1093/toxsci/59.1.169 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa K. Lingohr, Brian D. Thrall, and Richard J. Bull

Effects of Dichloroacetate (DCA) on Serum Insulin Levels and Insulin-Controlled Signaling Proteins in Livers of Male B6C3F1 Mice
Toxicol. Sci. 2001 59: 178-184; doi:10.1093/toxsci/59.1.178 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tong Lu, Jie Liu, Edward L. LeCluyse, Yun-Shu Zhou, Ming-Liang Cheng, and Michael P. Waalkes

Application of cDNA Microarray to the Study of Arsenic-Induced Liver Diseases in the Population of Guizhou, China
Toxicol. Sci. 2001 59: 185-192; doi:10.1093/toxsci/59.1.185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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