Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Scott W. Burchiel, Cindy M. Knall, John W. Davis, II, Richard S. Paules, Susan E. Boggs, and Cynthia A. Afshari

Analysis of Genetic and Epigenetic Mechanisms of Toxicity: Potential Roles of Toxicogenomics and Proteomics in Toxicology
Toxicol. Sci. 2001 59: 193-195; doi:10.1093/toxsci/59.2.193 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Arthur Furst

Moses Maimonides
Toxicol. Sci. 2001 59: 196-197; doi:10.1093/toxsci/59.2.196 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

I. Kimber, D. A. Basketter, K. Berthold, M. Butler, J.-L. Garrigue, L. Lea, C. Newsome, R. Roggeband, W. Steiling, G. Stropp, S. Waterman, and C. Wiemann

Skin Sensitization Testing in Potency and Risk Assessment
Toxicol. Sci. 2001 59: 198-208; doi:10.1093/toxsci/59.2.198 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Fredrik Jonsson, Frédéric Bois, and Gunnar Johanson

Physiologically Based Pharmacokinetic Modeling of Inhalation Exposure of Humans to Dichloromethane during Moderate to Heavy Exercise
Toxicol. Sci. 2001 59: 209-218; doi:10.1093/toxsci/59.2.209 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

David W. Gaylor and Ralph L. Kodell

Dose-Response Trend Tests for Tumorigenesis Adjusted for Differences in Survival and Body Weight across Doses
Toxicol. Sci. 2001 59: 219-225; doi:10.1093/toxsci/59.2.219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Adrian J. Fretland, Uday S. Devanaboyina, Yi Feng, Matthew A. Leff, Gong H. Xiao, Stephanie J. Webb, and David W. Hein

Oral Administration of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Yields PhIP-DNA Adducts but Not Tumors in Male Syrian Hamsters Congenic at the N-acetyltransferase 2 (NAT2) Locus
Toxicol. Sci. 2001 59: 226-230; doi:10.1093/toxsci/59.2.226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Kirsten C. Fertuck, Jason B. Matthews, and Tim R. Zacharewski

Hydroxylated Benzo[a]pyrene Metabolites Are Responsible for in Vitro Estrogen Receptor-Mediated Gene Expression Induced by Benzo[a]pyrene, but Do Not Elicit Uterotrophic Effects in Vivo
Toxicol. Sci. 2001 59: 231-240; doi:10.1093/toxsci/59.2.231 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Franck A. Atienzar, Victoria V. Cheung, Awadhesh N. Jha, and Michael H. Depledge

Fitness Parameters and DNA Effects Are Sensitive Indicators of Copper-Induced Toxicity in Daphnia magna
Toxicol. Sci. 2001 59: 241-250; doi:10.1093/toxsci/59.2.241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Andrew C. Dudley, Margie M. Peden-Adams, Jackie EuDaly, Richard S. Pollenz, and Deborah E. Keil

An Aryl Hydrocarbon Receptor Independent Mechanism of JP-8 Jet Fuel Immunotoxicity in Ah-Responsive and Ah-Nonresponsive Mice
Toxicol. Sci. 2001 59: 251-259; doi:10.1093/toxsci/59.2.251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Russell L. Carr, Howard W. Chambers, John A. Guarisco, Jason R. Richardson, Jun Tang, and Janice E. Chambers

Effects of Repeated Oral Postnatal Exposure to Chlorpyrifos on Open-Field Behavior in Juvenile Rats
Toxicol. Sci. 2001 59: 260-267; doi:10.1093/toxsci/59.2.260 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrew M. Geller, Wendy M. Oshiro, Najwa Haykal-Coates, Prasada R. S. Kodavanti, and Philip J. Bushnell

Gender-Dependent Behavioral and Sensory Effects of a Commercial Mixture of Polychlorinated Biphenyls (Aroclor 1254) in Rats
Toxicol. Sci. 2001 59: 268-277; doi:10.1093/toxsci/59.2.268 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. K. Parran, W. R. Mundy, and S. Barone, Jr.

Effects of Methylmercury and Mercuric Chloride on Differentiation and Cell Viability in PC12 Cells
Toxicol. Sci. 2001 59: 278-290; doi:10.1093/toxsci/59.2.278 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

B. J. Davis, H. C. Price, R. W. O'Connor, R. Fernando, A. S. Rowland, and D. L. Morgan

Mercury Vapor and Female Reproductive Toxicity
Toxicol. Sci. 2001 59: 291-296; doi:10.1093/toxsci/59.2.291 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gene E. Schulze, Richard J. Clay, Lawrence E. Mezza, Carla L. Bregman, Robert A. Buroker, and Jerry D. Frantz

BMS-189453, a Novel Retinoid Receptor Antagonist, Is a Potent Testicular Toxin
Toxicol. Sci. 2001 59: 297-308; doi:10.1093/toxsci/59.2.297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan R. Bielmeier, Deborah S. Best, Dorothy L. Guidici, and Michael G. Narotsky

Pregnancy Loss in the Rat Caused by Bromodichloromethane
Toxicol. Sci. 2001 59: 309-315; doi:10.1093/toxsci/59.2.309 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Carr J. Smith, Thomas H. Fischer, David L. Heavner, Melissa A. Rumple, Denise L. Bowman, Buddy G. Brown, Michael J. Morton, and David J. Doolittle

Urinary Thromboxane, Prostacyclin, Cortisol, and 8-Hydroxy-2'-deoxyguanosine in Nonsmokers Exposed and Not Exposed to Environmental Tobacco Smoke
Toxicol. Sci. 2001 59: 316-323; doi:10.1093/toxsci/59.2.316 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Donald G. Robertson, Michael A. Breider, and Mark A. Milad

Preclinical Safety Evaluation of Avasimibe in Beagle Dogs: An ACAT Inhibitor with Minimal Adrenal Effects
Toxicol. Sci. 2001 59: 324-334; doi:10.1093/toxsci/59.2.324 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Amit Kulkarni, A. J. Hopfinger, Rosemarie Osborne, Leon H. Bruner, and Edward D. Thompson

Prediction of Eye Irritation from Organic Chemicals Using Membrane-Interaction QSAR Analysis
Toxicol. Sci. 2001 59: 335-345; doi:10.1093/toxsci/59.2.335 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Margaret K. St. John, Lora L. Arnold, Traci Anderson, Martin Cano, Sonny L. Johansson, and Samuel M. Cohen

Dietary Effects of ortho-Phenylphenol and Sodium ortho-Phenylphenate on Rat Urothelium
Toxicol. Sci. 2001 59: 346-351; doi:10.1093/toxsci/59.2.346 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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