Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael I. Luster

Ozone-Induced Mucous Cell Metaplasia
Toxicol. Sci. 2001 60: 193; doi:10.1093/toxsci/60.2.193 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

B. D. Goldstein and M. A. Gallo

Paré's Law: The Second Law of Toxicology
Toxicol. Sci. 2001 60: 194-195; doi:10.1093/toxsci/60.2.194 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Ellen J. O'Flaherty, Brent D. Kerger, Sean M. Hays, and Dennis J. Paustenbach

A Physiologically Based Model for the Ingestion of Chromium(III) and Chromium(VI) by Humans
Toxicol. Sci. 2001 60: 196-213; doi:10.1093/toxsci/60.2.196 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melvin E. Andersen, Ramesh Sarangapani, Richard H. Reitz, Robert H. Gallavan, Ivan D. Dobrev, and Kathleen P. Plotzke

Physiological Modeling Reveals Novel Pharmacokinetic Behavior for Inhaled Octamethylcyclotetrasiloxane in Rats
Toxicol. Sci. 2001 60: 214-231; doi:10.1093/toxsci/60.2.214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

G. M. Nelson, A. E. Swank, L. R. Brooks, K. C. Bailey, and S. E. George

Metabolism, Microflora Effects, and Genotoxicity in Haloacetic Acid-Treated Cultures of Rat Cecal Microbiota
Toxicol. Sci. 2001 60: 232-241; doi:10.1093/toxsci/60.2.232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David C. Dorman, Melanie F. Struve, R. Arden James, Brian E. McManus, Marianne W. Marshall, and Brian A. Wong

Influence of Dietary Manganese on the Pharmacokinetics of Inhaled Manganese Sulfate in Male CD Rats
Toxicol. Sci. 2001 60: 242-251; doi:10.1093/toxsci/60.2.242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Madeleine V. Pahl, B. Dwight Culver, Philip L. Strong, F. Jay Murray, and Nosratola D. Vaziri

The Effect of Pregnancy on Renal Clearance of Boron in Humans: A Study Based on Normal Dietary Intake of Boron
Toxicol. Sci. 2001 60: 252-256; doi:10.1093/toxsci/60.2.252 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nosratola D. Vaziri, Fariba Oveisi, B. Dwight Culver, Madeleine V. Pahl, Melvin E. Andersen, Philip L. Strong, and F. Jay Murray

The Effect of Pregnancy on Renal Clearance of Boron in Rats Given Boric Acid Orally
Toxicol. Sci. 2001 60: 257-263; doi:10.1093/toxsci/60.2.257 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Janis E. Hulla, John E. French, and June K. Dunnick

Chromosome 11 Loss from Thymic Lymphomas Induced in Heterozygous Trp53 Mice by Phenolphthalein
Toxicol. Sci. 2001 60: 264-270; doi:10.1093/toxsci/60.2.264 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michelle L. O'Brien, Timothy P. Twaroski, Michael L. Cunningham, Howard P. Glauert, and Brett T. Spear

Effects of Peroxisome Proliferators on Antioxidant Enzymes and Antioxidant Vitamins in Rats and Hamsters
Toxicol. Sci. 2001 60: 271-278; doi:10.1093/toxsci/60.2.271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Petia P. Simeonova, Shiyi Wang, Michael L. Kashon, Choudari Kommineni, Eric Crecelius, and Michael I. Luster

Quantitative Relationship between Arsenic Exposure and AP-1 Activity in Mouse Urinary Bladder Epithelium
Toxicol. Sci. 2001 60: 279-284; doi:10.1093/toxsci/60.2.279 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

M. S. Marty, J. W. Crissman, and E. W. Carney

Evaluation of the Male Pubertal Onset Assay to Detect Testosterone and Steroid Biosynthesis Inhibitors in CD Rats
Toxicol. Sci. 2001 60: 285-295; doi:10.1093/toxsci/60.2.285 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nissanka Rajapakse, Delia Ong, and Andreas Kortenkamp

Defining the Impact of Weakly Estrogenic Chemicals on the Action of Steroidal Estrogens
Toxicol. Sci. 2001 60: 296-304; doi:10.1093/toxsci/60.2.296 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Mohammed B. Abou-Donia, Larry B. Goldstein, Katherine H. Jones, Ali A. Abdel-Rahman, Tirupapuliyur V. Damodaran, Anjelika M. Dechkovskaia, Sarah L. Bullman, Belal E. Amir, and Wasiuddin A. Khan

Locomotor and Sensorimotor Performance Deficit in Rats following Exposure to Pyridostigmine Bromide, DEET, and Permethrin, Alone and in Combination
Toxicol. Sci. 2001 60: 305-314; doi:10.1093/toxsci/60.2.305 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Virginia C. Moser, Timothy J. Shafer, Thomas R. Ward, Connie A. Meacham, Martha W. Harris, and Robert E. Chapin

Neurotoxicological Outcomes of Perinatal Heptachlor Exposure in the Rat
Toxicol. Sci. 2001 60: 315-326; doi:10.1093/toxsci/60.2.315 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Sherry E. Rier, Christopher L. Coe, Andrine M. Lemieux, Dan C. Martin, Richard Morris, George W. Lucier, and George C. Clark

Increased Tumor Necrosis Factor- Production by Peripheral Blood Leukocytes from TCDD-Exposed Rhesus Monkeys
Toxicol. Sci. 2001 60: 327-337; doi:10.1093/toxsci/60.2.327 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

James G. Wagner, Steven J. Van Dyken, Jon A. Hotchkiss, and Jack R. Harkema

Endotoxin Enhancement of Ozone-Induced Mucous Cell Metaplasia Is Neutrophil-Dependent in Rat Nasal Epithelium
Toxicol. Sci. 2001 60: 338-347; doi:10.1093/toxsci/60.2.338 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Clark Lantz, Ranulfo Lemus, Robert W. Lange, and Meryl H. Karol

Rapid Reduction of Intracellular Glutathione in Human Bronchial Epithelial Cells Exposed to Occupational Levels of Toluene Diisocyanate
Toxicol. Sci. 2001 60: 348-355; doi:10.1093/toxsci/60.2.348 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brian G. Nichols, James S. Woods, Daniel L. Luchtel, Jeannette Corral, and Jane Q. Koenig

Effects of Ozone Exposure on Nuclear Factor-B Activation and Tumor Necrosis Factor- Expression in Human Nasal Epithelial Cells
Toxicol. Sci. 2001 60: 356-362; doi:10.1093/toxsci/60.2.356 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

James V. Bruckner, Glenna M. Kyle, Raja Luthra, Daniel Acosta, Sanjay M. Mehta, Sankar Sethuraman, and Srinivasa Muralidhara

Acute, Short-Term, and Subchronic Oral Toxicity of 1,1,1-Trichloroethane in Rats
Toxicol. Sci. 2001 60: 363-372; doi:10.1093/toxsci/60.2.363 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Osmond J. D'Cruz and Fatih M. Uckun

Short-Term (13-week) Toxicity Study of 5-Bromo-6-methoxy-5,6- dihydro-3'-azidothymidine-5'-(p-bromophenyl) Methoxyalaninyl Phosphate (WHI-07), a Novel Anti-HIV and Contraceptive Agent, in B6C3F1 Mice
Toxicol. Sci. 2001 60: 373-378; doi:10.1093/toxsci/60.2.373 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Sheerin Mathur, Peter D. Constable, Robert M. Eppley, Mike E. Tumbleson, Geoffrey W. Smith, William J. Tranquilli, Dawn E. Morin, and Wanda M. Haschek

Fumonisin B₁ Increases Serum Sphinganine Concentration but Does Not Alter Serum Sphingosine Concentration or Induce Cardiovascular Changes in Milk-Fed Calves
Toxicol. Sci. 2001 60: 379-384; doi:10.1093/toxsci/60.2.379 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sheerin Mathur, Peter D. Constable, Robert M. Eppley, Amy L. Waggoner, Mike E. Tumbleson, and Wanda M. Haschek

Fumonisin B₁ Is Hepatotoxic and Nephrotoxic in Milk-Fed Calves
Toxicol. Sci. 2001 60: 385-396; doi:10.1093/toxsci/60.2.385 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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