Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Douglas McGregor and Gordon C. Hard

Renal Tubule Tumor Induction by Tertiary-Butyl Alcohol
Toxicol. Sci. 2001 61: 1-3; doi:10.1093/toxsci/61.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

William D. Wagner

Herbert E. Stokinger, "Mr. TLV"
Toxicol. Sci. 2001 61: 4-5; doi:10.1093/toxsci/61.1.4 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Yvonne P. Dragan, Wayne R. Bidlack, Samuel M. Cohen, Thomas L. Goldsworthy, Gordon C. Hard, Paul C. Howard, Ronald T. Riley, and Kenneth A. Voss

Implications of Apoptosis for Toxicity, Carcinogenicity, and Risk Assessment: Fumonisin B₁ as an Example
Toxicol. Sci. 2001 61: 6-17; doi:10.1093/toxsci/61.1.6 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew S. Bogdanffy, George Daston, Elaine M. Faustman, Carole A. Kimmel, Gary L. Kimmel, Jennifer Seed, and Vanessa Vu

Harmonization of Cancer and Noncancer Risk Assessment: Proceedings of a Consensus-Building Workshop
Toxicol. Sci. 2001 61: 18-31; doi:10.1093/toxsci/61.1.18 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lynne T. Haber, Andrew Maier, Qiyu Zhao, Joan S. Dollarhide, Russell E. Savage, and Michael L. Dourson

Applications of Mechanistic Data in Risk Assessment: The Past, Present, and Future
Toxicol. Sci. 2001 61: 32-39; doi:10.1093/toxsci/61.1.32 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

J. Thomas Sanderson, Lennert Slobbe, Gideon W. A. Lansbergen, Stephen Safe, and Martin van den Berg

2,3,7,8-Tetrachlorodibenzo-p-dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma Cells
Toxicol. Sci. 2001 61: 40-48; doi:10.1093/toxsci/61.1.40 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. King, W. Tang, J. Ngui, T. Tephly, and M. Braun

Characterization of Rat and Human UDP-Glucuronosyltransferases Responsible for the in Vitro Glucuronidation of Diclofenac
Toxicol. Sci. 2001 61: 49-53; doi:10.1093/toxsci/61.1.49 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. M. Sanders, L. T. Burka, B. Chanas, and H. B. Matthews

Comparative Xenobiotic Metabolism between Tg.AC and p53+/– Genetically Altered Mice and Their Respective Wild Types
Toxicol. Sci. 2001 61: 54-61; doi:10.1093/toxsci/61.1.54 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alexander Amberg, Elisabeth Rosner, and Wolfgang Dekant

Toxicokinetics of Methyl tert-Butyl Ether and Its Metabolites in Humans after Oral Exposure
Toxicol. Sci. 2001 61: 62-67; doi:10.1093/toxsci/61.1.62 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Michelle S. Cotroneo and Coral A. Lamartiniere

Pharmacologic, but Not Dietary, Genistein Supports Endometriosis in a Rat Model
Toxicol. Sci. 2001 61: 68-75; doi:10.1093/toxsci/61.1.68 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tong Zhou, David G. Ross, Michael J. DeVito, and Kevin M. Crofton

Effects of Short-Term in Vivo Exposure to Polybrominated Diphenyl Ethers on Thyroid Hormones and Hepatic Enzyme Activities in Weanling Rats
Toxicol. Sci. 2001 61: 76-82; doi:10.1093/toxsci/61.1.76 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

E. V. Thrane, M. Refsnes, G. H. Thoresen, M. Låg, and P. E. Schwarze

Fluoride-Induced Apoptosis in Epithelial Lung Cells Involves Activation of MAP Kinases p38 and Possibly JNK
Toxicol. Sci. 2001 61: 83-91; doi:10.1093/toxsci/61.1.83 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shuji Tsuda, Makiko Murakami, Naonori Matsusaka, Kiyoshi Kano, Kazuyuki Taniguchi, and Yu F. Sasaki

DNA Damage Induced by Red Food Dyes Orally Administered to Pregnant and Male Mice
Toxicol. Sci. 2001 61: 92-99; doi:10.1093/toxsci/61.1.92 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Michael L. Kirby, Rebecca L. Barlow, and Jeffrey R. Bloomquist

Neurotoxicity of the Organochlorine Insecticide Heptachlor to Murine Striatal Dopaminergic Pathways
Toxicol. Sci. 2001 61: 100-106; doi:10.1093/toxsci/61.1.100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wei Zheng, Yong-Ming Lu, Guo-Yao Lu, Qiuqu Zhao, Onpan Cheung, and William S. Blaner

Transthyretin, Thyroxine, and Retinol-Binding Protein in Human Cerebrospinal Fluid: Effect of Lead Exposure
Toxicol. Sci. 2001 61: 107-114; doi:10.1093/toxsci/61.1.107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

J. Odum, H. Tinwell, K. Jones, J. P. Van Miller, R. L. Joiner, G. Tobin, H. Kawasaki, R. Deghenghi, and J. Ashby

Effect of Rodent Diets on the Sexual Development of the Rat
Toxicol. Sci. 2001 61: 115-127; doi:10.1093/toxsci/61.1.115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lori A. Dostal, Paul Juneau, and Charles E. Rothwell

Repeated Analysis of Semen Parameters in Beagle Dogs during a 2-Year Study with the HMG-CoA Reductase Inhibitor, Atorvastatin
Toxicol. Sci. 2001 61: 128-134; doi:10.1093/toxsci/61.1.128 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

A. F. Hubbs, N. S. Minhas, W. Jones, M. Greskevitch, L. A. Battelli, D. W. Porter, W. T. Goldsmith, D. Frazer, D. P. Landsittel, J. Y. C. Ma, M. Barger, K. Hill, D. Schwegler-Berry, V. A. Robinson, and V. Castranova

Comparative Pulmonary Toxicity of 6 Abrasive Blasting Agents
Toxicol. Sci. 2001 61: 135-143; doi:10.1093/toxsci/61.1.135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joel Norwood, Jr., Alan D. Ledbetter, Donald L. Doerfler, and Gary E. Hatch

Residual Oil Fly Ash Inhalation in Guinea Pigs: Influence of Absorbate and Glutathione Depletion
Toxicol. Sci. 2001 61: 144-153; doi:10.1093/toxsci/61.1.144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gary M. Hellmann, Wanda R. Fields, and David J. Doolittle

Gene Expression Profiling of Cultured Human Bronchial Epithelial and Lung Carcinoma Cells
Toxicol. Sci. 2001 61: 154-163; doi:10.1093/toxsci/61.1.154 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

R. J. Smialowicz, W. C. Williams, C. B. Copeland, M. W. Harris, D. Overstreet, B. J. Davis, and R. E. Chapin

The Effects of Perinatal/Juvenile Heptachlor Exposure on Adult Immune and Reproductive System Function in Rats
Toxicol. Sci. 2001 61: 164-175; doi:10.1093/toxsci/61.1.164 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan J. Borghoff, Judith S. Prescott, Derek B. Janszen, Brian A. Wong, and Jeffery I. Everitt

2u-Globulin Nephropathy, Renal Cell Proliferation, and Dosimetry of Inhaled tert-Butyl Alcohol in Male and Female F-344 Rats
Toxicol. Sci. 2001 61: 176-186; doi:10.1093/toxsci/61.1.176 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Scott E. Heid, Mary K. Walker, and Hollie I. Swanson

Correlation of Cardiotoxicity Mediated by Halogenated Aromatic Hydrocarbons to Aryl Hydrocarbon Receptor Activation
Toxicol. Sci. 2001 61: 187-196; doi:10.1093/toxsci/61.1.187 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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