Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Bruce A. Fowler

Porphyrinurias Induced by Mercury and Other Metals
Toxicol. Sci. 2001 61: 197-198; doi:10.1093/toxsci/61.2.197 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Jens S. Schou and Christian M. Hodel

The Foundation and Functions of the International Union of Toxicology (IUTOX)
Toxicol. Sci. 2001 61: 199-200; doi:10.1093/toxsci/61.2.199 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Joseph K. Haseman, A. John Bailer, Ralph L. Kodell, Richard Morris, and Ken Portier

Statistical Issues in the Analysis of Low-Dose Endocrine Disruptor Data
Toxicol. Sci. 2001 61: 201-210; doi:10.1093/toxsci/61.2.201 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Michael Davis and William H. Farland

The Paradoxes of MTBE
Toxicol. Sci. 2001 61: 211-217; doi:10.1093/toxsci/61.2.211 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Anne C. Walsh, J. Amelia Feulner, and Andrew Reilly

Evidence for Functionally Significant Polymorphism of Human Glutamate Cysteine Ligase Catalytic Subunit: Association with Glutathione Levels and Drug Resistance in the National Cancer Institute Tumor Cell Line Panel
Toxicol. Sci. 2001 61: 218-223; doi:10.1093/toxsci/61.2.218 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephanie D. Pingree, P. Lynne Simmonds, and James S. Woods

Effects of 2,3-Dimercapto-1-propanesulfonic Acid (DMPS) on Tissue and Urine Mercury Levels following Prolonged Methylmercury Exposure in Rats
Toxicol. Sci. 2001 61: 224-233; doi:10.1093/toxsci/61.2.224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephanie D. Pingree, P. Lynne Simmonds, Kevin T. Rummel, and James S. Woods

Quantitative Evaluation of Urinary Porphyrins as a Measure of Kidney Mercury Content and Mercury Body Burden during Prolonged Methylmercury Exposure in Rats
Toxicol. Sci. 2001 61: 234-240; doi:10.1093/toxsci/61.2.234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Janet J. Diliberto, Michael J. DeVito, David G. Ross, and Linda S. Birnbaum

Subchronic Exposure of [³H]-2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female B6C3F1 Mice: Relationship of Steady-State Levels to Disposition and Metabolism
Toxicol. Sci. 2001 61: 241-255; doi:10.1093/toxsci/61.2.241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel A. Nazarenko, Stephen D. Dertinger, and Thomas A. Gasiewicz

In Vivo Antagonism of AhR-Mediated Gene Induction by 3'-Methoxy-4'-nitroflavone in TCDD-Responsive lacZ Mice
Toxicol. Sci. 2001 61: 256-264; doi:10.1093/toxsci/61.2.256 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Erica L. Dahl and R. Timothy Mulcahy

Cell-Type Specific Differences in Glutamate Cysteine Ligase Transcriptional Regulation Demonstrate Independent Subunit Control
Toxicol. Sci. 2001 61: 265-272; doi:10.1093/toxsci/61.2.265 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Amina Djerad, Claire Monier, Pascal Houzé, Stephen W. Borron, Jeanne-Marie Lefauconnier, and Frédéric J. Baud

Effects of Respiratory Acidosis and Alkalosis on the Distribution of Cyanide into the Rat Brain
Toxicol. Sci. 2001 61: 273-282; doi:10.1093/toxsci/61.2.273 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Jayanthika B. Wijeweera, A. Jay Gandolfi, Alan Parrish, and R. Clark Lantz

Sodium Arsenite Enhances AP-1 and NF B DNA Binding and Induces Stress Protein Expression in Precision-Cut Rat Lung Slices
Toxicol. Sci. 2001 61: 283-294; doi:10.1093/toxsci/61.2.283 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pius Joseph, Timothy K. Muchnok, Michelle L. Klishis, Jenny R. Roberts, James M. Antonini, Wen-Zong Whong, and Tong-man Ong

Cadmium-Induced Cell Transformation and Tumorigenesis Are Associated with Transcriptional Activation of c-fos, c-jun, and c-myc Proto-Oncogenes: Role of Cellular Calcium and Reactive Oxygen Species
Toxicol. Sci. 2001 61: 295-303; doi:10.1093/toxsci/61.2.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

J. T. Hamm, B. W. Wilson, and D. E. Hinton

Increasing Uptake and Bioactivation with Development Positively Modulate Diazinon Toxicity in Early Life Stage Medaka (Oryzias latipes)
Toxicol. Sci. 2001 61: 304-313; doi:10.1093/toxsci/61.2.304 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Jie Liu, Maria B. Kadiiska, Yaping Liu, Tong Lu, Wei Qu, and Michael P. Waalkes

Stress-Related Gene Expression in Mice Treated with Inorganic Arsenicals
Toxicol. Sci. 2001 61: 314-320; doi:10.1093/toxsci/61.2.314 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

L. Altmann, W. R. Mundy, T. R. Ward, A. Fastabend, and H. Lilienthal

Developmental Exposure of Rats to a Reconstituted PCB Mixture or Aroclor 1254: Effects on Long-Term Potentiation and [³H]MK-801 Binding in Occipital Cortex and Hippocampus
Toxicol. Sci. 2001 61: 321-330; doi:10.1093/toxsci/61.2.321 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

William J. Mautz, Michael T. Kleinman, Deepak K. Bhalla, and Robert F. Phalen

Respiratory Tract Responses to Repeated Inhalation of an Oxidant and Acid Gas-Particle Air Pollutant Mixture
Toxicol. Sci. 2001 61: 331-341; doi:10.1093/toxsci/61.2.331 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. Calderón-Garcidueñas, A. Mora-Tiscareño, L. A. Fordham, C. J. Chung, R. García, N. Osnaya, J. Hernández, H. Acuña, T. M. Gambling, A. Villarreal-Calderón, J. Carson, H. S. Koren, and R. B. Devlin

Canines as Sentinel Species for Assessing Chronic Exposures to Air Pollutants: Part 1. Respiratory Pathology
Toxicol. Sci. 2001 61: 342-355; doi:10.1093/toxsci/61.2.342 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. Calderón-Garcidueñas, T. M. Gambling, H. Acuña, R. García, N. Osnaya, S. Monroy, A. Villarreal-Calderón, J. Carson, H. S. Koren, and R. B. Devlin

Canines as Sentinel Species for Assessing Chronic Exposures to Air Pollutants: Part 2. Cardiac Pathology
Toxicol. Sci. 2001 61: 356-367; doi:10.1093/toxsci/61.2.356 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Takahide Kihara, Tien W. Surjono, Michiko Sakamoto, Takuya Matsuo, Yoshiko Yasuda, and Takashi Tanimura

Effects of Prenatal Rubratoxin-B Exposure on Behaviors of Mouse Offspring
Toxicol. Sci. 2001 61: 368-373; doi:10.1093/toxsci/61.2.368 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Marc L. Rigas, Miles S. Okino, and James J. Quackenboss

Use of a Pharmacokinetic Model to Assess Chlorpyrifos Exposure and Dose in Children, Based on Urinary Biomarker Measurements
Toxicol. Sci. 2001 61: 374-381; doi:10.1093/toxsci/61.2.374 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Maurice E. Knuckles, Frank Inyang, and Aramandla Ramesh

Acute and Subchronic Oral Toxicities of Benzo[a]pyrene in F-344 Rats
Toxicol. Sci. 2001 61: 382-388; doi:10.1093/toxsci/61.2.382 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Monika Schmelz, Vanessa J. Schmid, and Alan R. Parrish

Selective Disruption of Cadherin/Catenin Complexes by Oxidative Stress in Precision-Cut Mouse Liver Slices
Toxicol. Sci. 2001 61: 389-394; doi:10.1093/toxsci/61.2.389 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.