Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Rory B. Conolly

Biologically Motivated Quantitative Models and the Mixture Toxicity Problem
Toxicol. Sci. 2001 63: 1-2; doi:10.1093/toxsci/63.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Robert A. Scala

The Early Days of SOT
Toxicol. Sci. 2001 63: 3-5; doi:10.1093/toxsci/63.1.3 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Sidney Green, Alan Goldberg, and Joanne Zurlo

TestSmart–High Production Volume Chemicals: An Approach to Implementing Alternatives into Regulatory Toxicology
Toxicol. Sci. 2001 63: 6-14; doi:10.1093/toxsci/63.1.6 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

William P. Beierschmitt, John D. McNeish, Richard J. Griffiths, Atsushi Nagahisa, Masami Nakane, and David E. Amacher

Induction of Hepatic Microsomal Drug-Metabolizing Enzymes by Inhibitors of 5-Lipoxygenase (5-LO): Studies in Rats and 5-LO Knockout Mice
Toxicol. Sci. 2001 63: 15-21; doi:10.1093/toxsci/63.1.15 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. J. Kramer, H. Drenth, M. vandenBerg, W. Seinen, and J. DeJongh

Physiologically Based Pharmacokinetic Model for Tetrachlorobenzyltoluenes in Rat: Comparison of in Vitro and in Vivo Metabolic Rates
Toxicol. Sci. 2001 63: 22-28; doi:10.1093/toxsci/63.1.22 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Iván Csanaky and Zoltán Gregus

Effect of Phosphate Transporter and Methylation Inhibitor Drugs on the Disposition of Arsenate and Arsenite in Rats
Toxicol. Sci. 2001 63: 29-36; doi:10.1093/toxsci/63.1.29 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

James M. McKim, Jr., Paul C. Wilga, William J. Breslin, Kathy P. Plotzke, Robert H. Gallavan, and Robert G. Meeks

Potential Estrogenic and Antiestrogenic Activity of the Cyclic Siloxane Octamethylcyclotetrasiloxane (D4) and the Linear Siloxane Hexamethyldisiloxane (HMDS) in Immature Rats Using the Uterotrophic Assay
Toxicol. Sci. 2001 63: 37-46; doi:10.1093/toxsci/63.1.37 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katrina M. Waters, Stephen Safe, and Kevin W. Gaido

Differential Gene Expression in Response to Methoxychlor and Estradiol through ER, ERß, and AR in Reproductive Tissues of Female Mice
Toxicol. Sci. 2001 63: 47-56; doi:10.1093/toxsci/63.1.47 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Thomas M. Jeitner and David A. Lawrence

Mechanisms for the Cytotoxicity of Cysteamine
Toxicol. Sci. 2001 63: 57-64; doi:10.1093/toxsci/63.1.57 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Zeiger, R. Haag, J. Höckel, D. Schrenk, and H.-J. Schmitz

Inducing Effects of Dioxin-like Polychlorinated Biphenyls on CYP1A in the Human Hepatoblastoma Cell Line HepG2, the Rat Hepatoma Cell Line H4IIE, and Rat Primary Hepatocytes: Comparison of Relative Potencies
Toxicol. Sci. 2001 63: 65-73; doi:10.1093/toxsci/63.1.65 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

J. B. Sass, D. T. Haselow, and E. K. Silbergeld

Methylmercury-Induced Decrement in Neuronal Migration May Involve Cytokine-Dependent Mechanisms: A Novel Method to Assess Neuronal Movement in Vitro
Toxicol. Sci. 2001 63: 74-81; doi:10.1093/toxsci/63.1.74 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Ralph Rühl, Claudia Plum, Mohamed M. A. Elmazar, and Heinz Nau

Embryonic Subcellular Distribution of 13-cis- and All-trans-Retinoic Acid Indicates Differential Cytosolic/Nuclear Localization
Toxicol. Sci. 2001 63: 82-89; doi:10.1093/toxsci/63.1.82 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Anna Clouter, David Brown, Doris Höhr, Paul Borm, and Ken Donaldson

Inflammatory Effects of Respirable Quartz Collected in Workplaces versus Standard DQ12 Quartz: Particle Surface Correlates
Toxicol. Sci. 2001 63: 90-98; doi:10.1093/toxsci/63.1.90 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Il Je Yu, Kyung Seuk Song, Hee Kyung Chang, Jeong Hee Han, Kwang Jin Kim, Yong Hyun Chung, Seung Hee Maeng, Seung Hyun Park, Kuy Tae Han, Kyu Hyuk Chung, and Ho Keun Chung

Lung Fibrosis in Sprague-Dawley Rats, Induced by Exposure to Manual Metal Arc–Stainless Steel Welding Fumes
Toxicol. Sci. 2001 63: 99-106; doi:10.1093/toxsci/63.1.99 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wanda R. Fields, Joseph G. Desiderio, Kathy P. Putnam, David W. Bombick, and David J. Doolittle

Quantification of Changes in c-myc mRNA Levels in Normal Human Bronchial Epithelial (NHBE) and Lung Adenocarcinoma (A549) Cells following Chemical Treatment
Toxicol. Sci. 2001 63: 107-114; doi:10.1093/toxsci/63.1.107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eiko Koike, Takahiro Kobayashi, and Nobuhiro Shimojo

Ozone Exposure Enhances Expression of Cell-Surface Molecules Associated with Antigen-Presenting Activity on Bronchoalveolar Lavage Cells in Rats
Toxicol. Sci. 2001 63: 115-124; doi:10.1093/toxsci/63.1.115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Sami Haddad, Martin Béliveau, Robert Tardif, and Kannan Krishnan

A PBPK Modeling-Based Approach to Account for Interactions in the Health Risk Assessment of Chemical Mixtures
Toxicol. Sci. 2001 63: 125-131; doi:10.1093/toxsci/63.1.125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Dong-Soon Bae, Chris Gennings, Walter H. Carter, Jr., Raymond S. H. Yang, and Julie A. Campain

Toxicological Interactions among Arsenic, Cadmium, Chromium, and Lead in Human Keratinocytes
Toxicol. Sci. 2001 63: 132-142; doi:10.1093/toxsci/63.1.132 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Lisa M. Walker, J. Lyndal York, Syed Z. Imam, Syed F. Ali, Kenneth L. Muldrew, and Philip R. Mayeux

Oxidative Stress and Reactive Nitrogen Species Generation during Renal Ischemia
Toxicol. Sci. 2001 63: 143-148; doi:10.1093/toxsci/63.1.143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Edward J. Calabrese and Linda A. Baldwin

Letter
Toxicol. Sci. 2001 63: 149; doi:10.1093/toxsci/63.1.149 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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