Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Brad L. Upham and James G. Wagner

Toxicant-Induced Oxidative Stress in Cancer
Toxicol. Sci. 2001 64: 1-3; doi:10.1093/toxsci/64.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Hanspeter Witschi

A Short History of Lung Cancer
Toxicol. Sci. 2001 64: 4-6; doi:10.1093/toxsci/64.1.4 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Thomas B. Starr

Significant Shortcomings of the U.S. Environmental Protection Agency's Latest Draft Risk Characterization for Dioxin-Like Compounds
Toxicol. Sci. 2001 64: 7-13; doi:10.1093/toxsci/64.1.7 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Samuel M. Cohen, Denise Robinson, and James MacDonald

Alternative Models for Carcinogenicity Testing
Toxicol. Sci. 2001 64: 14-19; doi:10.1093/toxsci/64.1.14 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Dongfang Yang, Yuxin Li, Xiong Yuan, Lynn Matoney, and Bingfang Yan

Regulation of Rat Carboxylesterase Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): A Dose-Dependent Decrease in mRNA Levels but a Biphasic Change in Protein Levels and Activity
Toxicol. Sci. 2001 64: 20-27; doi:10.1093/toxsci/64.1.20 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Barbara C. Gottschling, Robert R. Maronpot, James R. Hailey, Shyamal Peddada, Cindy R. Moomaw, James E. Klaunig, and Abraham Nyska

The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats
Toxicol. Sci. 2001 64: 28-40; doi:10.1093/toxsci/64.1.28 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Brenda A. Jensen and Mark E. Hahn

cDNA Cloning and Characterization of a High Affinity Aryl Hydrocarbon Receptor in a Cetacean, the Beluga, Delphinapterus leucas
Toxicol. Sci. 2001 64: 41-56; doi:10.1093/toxsci/64.1.41 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

T. L. Bunn, P. J. Parsons, E. Kao, and R. R. Dietert

Exposure to Lead during Critical Windows of Embryonic Development: Differential Immunotoxic Outcome Based on Stage of Exposure and Gender
Toxicol. Sci. 2001 64: 57-66; doi:10.1093/toxsci/64.1.57 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Janice M. DeMoor, Wendy A. Kennette, Olga M. Collins, and James Koropatnick

Zinc-Metallothionein Levels Are Correlated with Enhanced Glucocorticoid Responsiveness in Mouse Cells Exposed to ZnCl₂, HgCl₂, and Heat Shock
Toxicol. Sci. 2001 64: 67-76; doi:10.1093/toxsci/64.1.67 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Robert A. Yokel, Susan S. Rhineheimer, Pankaj Sharma, David Elmore, and Patrick J. McNamara

Entry, Half-Life, and Desferrioxamine-Accelerated Clearance of Brain Aluminum after a Single ²⁶Al Exposure
Toxicol. Sci. 2001 64: 77-82; doi:10.1093/toxsci/64.1.77 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Palur Gunasekar, Li Li, Krishnan Prabhakaran, Vladislav Eybl, Joseph L. Borowitz, and Gary E. Isom

Mechanisms of the Apoptotic and Necrotic Actions of Trimethyltin in Cerebellar Granule Cells
Toxicol. Sci. 2001 64: 83-89; doi:10.1093/toxsci/64.1.83 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ping Li and Toby G. Rossman

Genes Upregulated in Lead-Resistant Glioma Cells Reveal Possible Targets for Lead-Induced Developmental Neurotoxicity
Toxicol. Sci. 2001 64: 90-99; doi:10.1093/toxsci/64.1.90 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

J. S. Kimbell, R. P. Subramaniam, E. A. Gross, P. M. Schlosser, and K. T. Morgan

Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local Flux Predictions in the Rat, Monkey, and Human Nasal Passages
Toxicol. Sci. 2001 64: 100-110; doi:10.1093/toxsci/64.1.100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. S. Kimbell, J. H. Overton, R. P. Subramaniam, P. M. Schlosser, K. T. Morgan, R. B. Conolly, and F. J. Miller

Dosimetry Modeling of Inhaled Formaldehyde: Binning Nasal Flux Predictions for Quantitative Risk Assessment
Toxicol. Sci. 2001 64: 111-121; doi:10.1093/toxsci/64.1.111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John H. Overton, Julia S. Kimbell, and Frederick J. Miller

Dosimetry Modeling of Inhaled Formaldehyde: The Human Respiratory Tract
Toxicol. Sci. 2001 64: 122-134; doi:10.1093/toxsci/64.1.122 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

S. Muralidhara, R. Ramanathan, S. M. Mehta, L. H. Lash, D. Acosta, and J. V. Bruckner

Acute, Subacute, and Subchronic Oral Toxicity Studies of 1,1-Dichloroethane in Rats: Application to Risk Evaluation
Toxicol. Sci. 2001 64: 135-145; doi:10.1093/toxsci/64.1.135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

ERRATUM
Toxicol. Sci. 2001 64: 0; doi:10.1093/toxsci/64.1.0 [Extract] [FREE Full Text] [Request Permissions]  

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