Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Jay I. Goodman

Operational Reversibility is a Key Aspect of Carcinogenesis
Toxicol. Sci. 2001 64: 147-148; doi:10.1093/toxsci/64.2.147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Morton Lippmann

Norton Nelson
Toxicol. Sci. 2001 64: 149-150; doi:10.1093/toxsci/64.2.149 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Rogelio Tornero-Velez and Stephen M. Rappaport

Physiological Modeling of the Relative Contributions of Styrene-7,8-oxide Derived from Direct Inhalation and from Styrene Metabolism to the Systemic Dose in Humans
Toxicol. Sci. 2001 64: 151-161; doi:10.1093/toxsci/64.2.151 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shelley A. Larsen-Su and David E. Williams

Transplacental Exposure to Indole-3-carbinol Induces Sex-Specific Expression of CYP1A1 and CYP1B1 in the Liver of Fischer 344 Neonatal Rats
Toxicol. Sci. 2001 64: 162-168; doi:10.1093/toxsci/64.2.162 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michèle Bouchard, Robert C. Brunet, Pierre-Olivier Droz, and Gaétan Carrier

A Biologically Based Dynamic Model for Predicting the Disposition of Methanol and Its Metabolites in Animals and Humans
Toxicol. Sci. 2001 64: 169-184; doi:10.1093/toxsci/64.2.169 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Terry R. Van Vleet, David W. Bombick, and Roger A. Coulombe, Jr.

Inhibition of Human Cytochrome P450 2E1 by Nicotine, Cotinine, and Aqueous Cigarette Tar Extract in Vitro
Toxicol. Sci. 2001 64: 185-191; doi:10.1093/toxsci/64.2.185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Jason S. Isenberg, Lisa M. Kamendulis, David C. Ackley, Jacqueline H. Smith, George Pugh, Jr., Arthur W. Lington, Richard H. McKee, and James E. Klaunig

Reversibility and Persistence of Di-2-ethylhexyl Phthalate (DEHP)- and Phenobarbital-Induced Hepatocellular Changes in Rodents
Toxicol. Sci. 2001 64: 192-199; doi:10.1093/toxsci/64.2.192 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Juan Wang, Sonja Grisle, and Daniel Schlenk

Effects of Salinity on Aldicarb Toxicity in Juvenile Rainbow Trout (Oncorhynchus mykiss) and Striped Bass (Morone saxatilis x chrysops)
Toxicol. Sci. 2001 64: 200-207; doi:10.1093/toxsci/64.2.200 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Ryuya Shimoda, Takeaki Nagamine, Hitoshi Takagi, Masatomo Mori, and Michael P. Waalkes

Induction of Apoptosis in Cells by Cadmium: Quantitative Negative Correlation between Basal or Induced Metallothionein Concentration and Apoptotic Rate
Toxicol. Sci. 2001 64: 208-215; doi:10.1093/toxsci/64.2.208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Sherry Purkerson-Parker, Katherine L. McDaniel, and Virginia C. Moser

Dopamine Transporter Binding in the Rat Striatum Is Increased by Gestational, Perinatal, and Adolescent Exposure to Heptachlor
Toxicol. Sci. 2001 64: 216-223; doi:10.1093/toxsci/64.2.216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Minoru Omura, Rika Ogata, Kazuhiko Kubo, Yohei Shimasaki, Shuji Aou, Yuji Oshima, Akiyo Tanaka, Miyuki Hirata, Yuji Makita, and Naohide Inoue

Two-Generation Reproductive Toxicity Study of Tributyltin Chloride in Male Rats
Toxicol. Sci. 2001 64: 224-232; doi:10.1093/toxsci/64.2.224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Valerie D. Shultz, Suzanne Phillips, Madhabananda Sar, Paul M. D. Foster, and Kevin W. Gaido

Altered Gene Profiles in Fetal Rat Testes after in Utero Exposure to Di(n-butyl) Phthalate
Toxicol. Sci. 2001 64: 233-242; doi:10.1093/toxsci/64.2.233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Matthew J. Campen, Julianne P. Nolan, Mette C. J. Schladweiler, Urmila P. Kodavanti, Paul A. Evansky, Daniel L. Costa, and William P. Watkinson

Cardiovascular and Thermoregulatory Effects of Inhaled PM-Associated Transition Metals: A Potential Interaction between Nickel and Vanadium Sulfate
Toxicol. Sci. 2001 64: 243-252; doi:10.1093/toxsci/64.2.243 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James T. Kelly, Carol M. Bobbitt, and Bahman Asgharian

In Vivo Measurement of Fine and Coarse Aerosol Deposition in the Nasal Airways of Female Long-Evans Rats
Toxicol. Sci. 2001 64: 253-258; doi:10.1093/toxsci/64.2.253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Kimiyuki Kaneko, Kazumi Uchida, Toshihide Kobayashi, Kouzou Miura, Keiko Tanokura, Kayoko Hoshino, Ikuo Kato, Masaharu Onoue, and Teruo Yokokura

Sex-Dependent Toxicity of a Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitor, YIC-C8-434, in Relation to Sex-Specific Forms of Cytochrome P450 in Rats
Toxicol. Sci. 2001 64: 259-268; doi:10.1093/toxsci/64.2.259 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Vincent R. Torti, Alison J. Cobb, Jeffrey I. Everitt, Marianne W. Marshall, Gary A. Boorman, and Byron E. Butterworth

Nephrotoxicity and Hepatotoxicity Induced by Inhaled Bromodichloromethane in Wild-Type and p53-Heterozygous Mice
Toxicol. Sci. 2001 64: 269-280; doi:10.1093/toxsci/64.2.269 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Janis E. Hulla

Letter
Toxicol. Sci. 2001 64: 281-282; doi:10.1093/toxsci/64.2.281 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

James Huff

Carcinogencity Bioassays of Bisphenol A, 4-Vinylcyclohexene Diepoxide, and 4-Vinycyclohexene
Toxicol. Sci. 2001 64: 282-283; doi:10.1093/toxsci/64.2.282 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

I. Glenn Sipes, Patricia B. Hoyer, and P. J. Devine

Reply
Toxicol. Sci. 2001 64: 284; doi:10.1093/toxsci/64.2.284 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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