Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Konstantin Salnikow and Mitchell D. Cohen

Backing into Cancer: Effects of Arsenic on Cell Differentiation
Toxicol. Sci. 2002 65: 161-163; doi:10.1093/toxsci/65.2.161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Andrew L. Reeves

Arthur John Vorwald, 1904–1974
Toxicol. Sci. 2002 65: 164-165; doi:10.1093/toxsci/65.2.164 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Hartmut Jaeschke, Gregory J. Gores, Arthur I. Cederbaum, Jack A. Hinson, Dominique Pessayre, and John J. Lemasters

Mechanisms of Hepatotoxicity
Toxicol. Sci. 2002 65: 166-176; doi:10.1093/toxsci/65.2.166 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Joungjoa Park, Lisa M. Kamendulis, Marvin A. Friedman, and James E. Klaunig

Acrylamide-Induced Cellular Transformation
Toxicol. Sci. 2002 65: 177-183; doi:10.1093/toxsci/65.2.177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Nichole R. Vansell and Curtis D. Klaassen

Effect of Microsomal Enzyme Inducers on the Biliary Excretion of Triiodothyronine (T₃) and Its Metabolites
Toxicol. Sci. 2002 65: 184-191; doi:10.1093/toxsci/65.2.184 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Hiroki Teraoka, Wu Dong, Shuji Ogawa, Shusaku Tsukiyama, Yuji Okuhara, Masayoshi Niiyama, Naoto Ueno, Richard E. Peterson, and Takeo Hiraga

2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Altered Regional Blood Flow and Impaired Lower Jaw Development
Toxicol. Sci. 2002 65: 192-199; doi:10.1093/toxsci/65.2.192 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Scott R. Nagy, James R. Sanborn, Bruce D. Hammock, and Michael S. Denison

Development of a Green Fluorescent Protein-Based Cell Bioassay for the Rapid and Inexpensive Detection and Characterization of Ah Receptor Agonists
Toxicol. Sci. 2002 65: 200-210; doi:10.1093/toxsci/65.2.200 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Eric M. Wauson, Amy S. Langan, and Roseann L. Vorce

Sodium Arsenite Inhibits and Reverses Expression of Adipogenic and Fat Cell-Specific Genes during in Vitro Adipogenesis
Toxicol. Sci. 2002 65: 211-219; doi:10.1093/toxsci/65.2.211 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vida Mildaziene, Zita Nauciene, Rasa Baniene, and Jurgita Grigiene

Multiple Effects of 2,2`,5,5`-Tetrachlorobiphenyl on Oxidative Phosphorylation in Rat Liver Mitochondria
Toxicol. Sci. 2002 65: 220-227; doi:10.1093/toxsci/65.2.220 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Coral A. Lamartiniere, Jun Wang, Michelle Smith-Johnson, and Isam-Eldin Eltoum

Daidzein: Bioavailability, Potential for Reproductive Toxicity, and Breast Cancer Chemoprevention in Female Rats
Toxicol. Sci. 2002 65: 228-238; doi:10.1093/toxsci/65.2.228 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

T. G. Rand, M. Mahoney, K. White, and M. Oulton

Microanatomical Changes in Alveolar Type II Cells in Juvenile Mice Intratracheally Exposed to Stachybotrys chartarum Spores and Toxin
Toxicol. Sci. 2002 65: 239-245; doi:10.1093/toxsci/65.2.239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Keikou Okasaki, Mamoru Funato, Masatoshi Kashima, Kazuhiro Nakama, Takatoshi Inoue, Masanori Hiura, Yuzuru Kato, and Ryoichi Nagata

Twenty-Six-Week Repeat-Dose Toxicity Study of a Recombinant Human Granulocyte Colony-Stimulating Factor Derivative (Nartograstim) in Cynomolgus Monkeys
Toxicol. Sci. 2002 65: 246-255; doi:10.1093/toxsci/65.2.246 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard E. Morrissey, Christopher Horvath, Eileen A. Snyder, James Patrick, Nathaniel Collins, Ellen Evans, and James S. MacDonald

Porcine Toxicology Studies of SCH 58500, an Adenoviral Vector for the p53 Gene
Toxicol. Sci. 2002 65: 256-265; doi:10.1093/toxsci/65.2.256 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard E. Morrissey, Christopher Horvath, Eileen A. Snyder, James Patrick, and James S. MacDonald

Rodent Nonclinical Safety Evaluation Studies of SCH 58500, an Adenoviral Vector for the p53 Gene
Toxicol. Sci. 2002 65: 266-275; doi:10.1093/toxsci/65.2.266 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. E. Stebbins, D. M. Bond, M. N. Novilla, and M. J. Reasor

Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice
Toxicol. Sci. 2002 65: 276-287; doi:10.1093/toxsci/65.2.276 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. L. Yano, D. M. Bond, M. N. Novilla, L. G. McFadden, and M. J. Reasor

Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats
Toxicol. Sci. 2002 65: 288-298; doi:10.1093/toxsci/65.2.288 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

María José Gómez-Lechón, Enrique O'Connor, José Vicente Castell, and Ramiro Jover

Sensitive Markers Used to Identify Compounds That Trigger Apoptosis in Cultured Hepatocytes
Toxicol. Sci. 2002 65: 299-308; doi:10.1093/toxsci/65.2.299 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bryan L. Copple, Amy Banes, Patricia E. Ganey, and Robert A. Roth

Endothelial Cell Injury and Fibrin Deposition in Rat Liver after Monocrotaline Exposure
Toxicol. Sci. 2002 65: 309-318; doi:10.1093/toxsci/65.2.309 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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