Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Thais C. Morata

Interaction between Noise and Asphyxiants: A Concern for Toxicology and Occupational Health
Toxicol. Sci. 2002 66: 1-3; doi:10.1093/toxsci/66.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Jerold A. Last

The Missing Link: The Story of Karl Paul Link
Toxicol. Sci. 2002 66: 4-6; doi:10.1093/toxsci/66.1.4 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Frederic J.-M. Moulin, Karrie A. Brenneman, Julia S. Kimbell, and David C. Dorman

Predicted Regional Flux of Hydrogen Sulfide Correlates with Distribution of Nasal Olfactory Lesions in Rats
Toxicol. Sci. 2002 66: 7-15; doi:10.1093/toxsci/66.1.7 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David R. Johnson, Sultan S. M. Habeebu, and Curtis D. Klaassen

Increase in Bile Flow and Biliary Excretion of Glutathione-Derived Sulfhydryls in Rats by Drug-Metabolizing Enzyme Inducers Is Mediated by Multidrug Resistance Protein 2
Toxicol. Sci. 2002 66: 16-26; doi:10.1093/toxsci/66.1.16 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. J. Bray, N. B. Perry, D. B. Menkes, and R. J. Rosengren

St. John's Wort Extract Induces CYP3A and CYP2E1 in the Swiss Webster Mouse
Toxicol. Sci. 2002 66: 27-33; doi:10.1093/toxsci/66.1.27 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. Timchalk, R. J. Nolan, A. L. Mendrala, D. A. Dittenber, K. A. Brzak, and J. L. Mattsson

A Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model for the Organophosphate Insecticide Chlorpyrifos in Rats and Humans
Toxicol. Sci. 2002 66: 34-53; doi:10.1093/toxsci/66.1.34 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

C. E. Dean, Jr., S. A. Benjamin, L. S. Chubb, J. D. Tessari, and T. J. Keefe

Nonadditive Hepatic Tumor Promoting Effects by a Mixture of Two Structurally Different Polychlorinated Biphenyls in Female Rat Livers
Toxicol. Sci. 2002 66: 54-61; doi:10.1093/toxsci/66.1.54 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

David L. Buchanan, Seiichiro Ohsako, Chiharu Tohyama, Paul S. Cooke, and Taisen Iguchi

Dioxin Inhibition of Estrogen-Induced Mouse Uterine Epithelial Mitogenesis Involves Changes in Cyclin and Transforming Growth Factor-ß Expression
Toxicol. Sci. 2002 66: 62-68; doi:10.1093/toxsci/66.1.62 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vickie S. Wilson, Kathy Bobseine, Christy R. Lambright, and L. E. Gray, Jr.

A Novel Cell Line, MDA-kb2, That Stably Expresses an Androgen- and Glucocorticoid-Responsive Reporter for the Detection of Hormone Receptor Agonists and Antagonists
Toxicol. Sci. 2002 66: 69-81; doi:10.1093/toxsci/66.1.69 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. C. Hartig, K. L. Bobseine, B. H. Britt, M. C. Cardon, C. R. Lambright, V. S. Wilson, and L. E. Gray, Jr.

Development of Two Androgen Receptor Assays Using Adenoviral Transduction of MMTV-Luc Reporter and/or hAR for Endocrine Screening
Toxicol. Sci. 2002 66: 82-90; doi:10.1093/toxsci/66.1.82 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Li You, Mercedes Casanova, Erika J. Bartolucci, Mary W. Fryczynski, David C. Dorman, Jeffrey I. Everitt, Kevin W. Gaido, Susan M. Ross, and Henry d'A. Heck

Combined Effects of Dietary Phytoestrogen and Synthetic Endocrine-Active Compound on Reproductive Development in Sprague-Dawley Rats: Genistein and Methoxychlor
Toxicol. Sci. 2002 66: 91-104; doi:10.1093/toxsci/66.1.91 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tong Zhou, Michele M. Taylor, Michael J. DeVito, and Kevin M. Crofton

Developmental Exposure to Brominated Diphenyl Ethers Results in Thyroid Hormone Disruption
Toxicol. Sci. 2002 66: 105-116; doi:10.1093/toxsci/66.1.105 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

H. Fujimaki, K. Nohara, T. Kobayashi, K. Suzuki, K. Eguchi-Kasai, S. Tsukumo, M. Kijima, and C. Tohyama

Effect of a Single Oral Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Immune Function in Male NC/Nga Mice
Toxicol. Sci. 2002 66: 117-124; doi:10.1093/toxsci/66.1.117 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Zora Djuric, Sherry M. Lewis, Ming H. Lu, Martha Mayhugh, Lilian Naegeli, Ning Tang, and Ronald W. Hart

Effect of Varying Caloric Restriction Levels on Female Rat Growth and 5-Hydroxymethyl-2'-deoxyuridine in DNA
Toxicol. Sci. 2002 66: 125-130; doi:10.1093/toxsci/66.1.125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Laurence D. Fechter, Guang-Di Chen, and David L. Johnson

Potentiation of Noise-Induced Hearing Loss by Low Concentrations of Hydrogen Cyanide in Rats
Toxicol. Sci. 2002 66: 131-138; doi:10.1093/toxsci/66.1.131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. M. Lasley and M. E. Gilbert

Rat Hippocampal Glutamate and GABA Release Exhibit Biphasic Effects as a Function of Chronic Lead Exposure Level
Toxicol. Sci. 2002 66: 139-147; doi:10.1093/toxsci/66.1.139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mohamed B. Abou-Donia, Anjelika M. Dechkovskaia, Larry B. Goldstein, Sarah L. Bullman, and Wasiuddin A. Khan

Sensorimotor Deficit and Cholinergic Changes following Coexposure with Pyridostigmine Bromide and Sarin in Rats
Toxicol. Sci. 2002 66: 148-158; doi:10.1093/toxsci/66.1.148 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Umesh M. Hanumegowda, Barbara M. Judy, Wade V. Welshons, and Chada S. Reddy

Selective Inhibition of Murine Palatal Mesenchymal Cell Proliferation in Vitro by Secalonic Acid D
Toxicol. Sci. 2002 66: 159-165; doi:10.1093/toxsci/66.1.159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Geneviève Durand, Marie-Françoise Hubert, Hiroshi Kuno, William O. Cook, Christine Boussiquet-Leroux, Roger Owen, Yukio Fujimaki, Masayuki Kemi, Michel Virat, and Matthew J. van Zwieten

Muscarinic Receptor Antagonist-Induced Lenticular Opacity in Rats
Toxicol. Sci. 2002 66: 166-172; doi:10.1093/toxsci/66.1.166 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.