Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Paul M. Newberne

Choline Deficiency Associated with Diethanolamine Carcinogenicity
Toxicol. Sci. 2002 67: 1-3; doi:10.1093/toxsci/67.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Elliot M. Friedman and David A. Lawrence

Environmental Stress Mediates Changes in Neuroimmunological Interactions
Toxicol. Sci. 2002 67: 4-10; doi:10.1093/toxsci/67.1.4 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rebecca E. Watson and Jay I. Goodman

Epigenetics and DNA Methylation Come of Age in Toxicology
Toxicol. Sci. 2002 67: 11-16; doi:10.1093/toxsci/67.1.11 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Torka S. Poet, Karl K. Weitz, Richard A. Gies, Jeffrey A. Edwards, Karla D. Thrall, Richard A. Corley, Hanafi Tanojo, Xiaoying Hui, Howard I. Maibach, and Ronald C. Wester

PBPK Modeling of the Percutaneous Absorption of Perchloroethylene from a Soil Matrix in Rats and Humans
Toxicol. Sci. 2002 67: 17-31; doi:10.1093/toxsci/67.1.17 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Terry Gordon, Jonathan Spanier, John H. Butala, Ping Li, and Toby G. Rossman

In Vitro Bioavailability of Heavy Metals in Pressure-Treated Wood Dust
Toxicol. Sci. 2002 67: 32-37; doi:10.1093/toxsci/67.1.32 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Lois D. Lehman-McKeeman, Elizabeth A. Gamsky, Sarah M. Hicks, Jeffrey D. Vassallo, Mei-Heng Mar, and Steven H. Zeisel

Diethanolamine Induces Hepatic Choline Deficiency in Mice
Toxicol. Sci. 2002 67: 38-45; doi:10.1093/toxsci/67.1.38 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Catherine Pelletier, Eric Doucet, Pascal Imbeault, and Angelo Tremblay

Associations between Weight Loss-Induced Changes in Plasma Organochlorine Concentrations, Serum T₃ Concentration, and Resting Metabolic Rate
Toxicol. Sci. 2002 67: 46-51; doi:10.1093/toxsci/67.1.46 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hyung Sik Kim, Jae-Ho Shin, Hyun Ju Moon, Tae Sung Kim, Il Hyun Kang, Ji-Hyun Seok, In Young Kim, Kui Lea Park, and Soon Young Han

Evaluation of the 20-Day Pubertal Female Assay in Sprague-Dawley Rats Treated with DES, Tamoxifen, Testosterone, and Flutamide
Toxicol. Sci. 2002 67: 52-62; doi:10.1093/toxsci/67.1.52 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Suzanne E. Fenton, Jonathan T. Hamm, Linda S. Birnbaum, and Geri L. Youngblood

Persistent Abnormalities in the Rat Mammary Gland following Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Toxicol. Sci. 2002 67: 63-74; doi:10.1093/toxsci/67.1.63 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

T. Rouhani Rankouhi, I. van Holsteijn, R. Letcher, J. P. Giesy, and M. van den Berg

Effects of Primary Exposure to Environmental and Natural Estrogens on Vitellogenin Production in Carp (Cyprinus carpio) Hepatocytes
Toxicol. Sci. 2002 67: 75-80; doi:10.1093/toxsci/67.1.75 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maria T. Runnegar, Chaoyu Xie, Barry B. Snider, Grier A. Wallace, Steven M. Weinreb, and John Kuhlenkamp

In Vitro Hepatotoxicity of the Cyanobacterial Alkaloid Cylindrospermopsin and Related Synthetic Analogues
Toxicol. Sci. 2002 67: 81-87; doi:10.1093/toxsci/67.1.81 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Lisa K. Ryan, Lisa R. Copeland, Mary J. Daniels, Elisabeth R. Costa, and Mary Jane K. Selgrade

Proinflammatory and Th1 Cytokine Alterations following Ultraviolet Radiation Enhancement of Disease Due to Influenza Infection in Mice
Toxicol. Sci. 2002 67: 88-97; doi:10.1093/toxsci/67.1.88 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

P. Eriksson, H. Viberg, E. Jakobsson, U. Örn, and A. Fredriksson

A Brominated Flame Retardant, 2,2`,4,4`,5-Pentabromodiphenyl Ether: Uptake, Retention, and Induction of Neurobehavioral Alterations in Mice during a Critical Phase of Neonatal Brain Development
Toxicol. Sci. 2002 67: 98-103; doi:10.1093/toxsci/67.1.98 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Henrik Viberg, Anders Fredriksson, and Per Eriksson

Neonatal Exposure to the Brominated Flame Retardant 2,2`,4,4`,5-Pentabromodiphenyl Ether Causes Altered Susceptibility in the Cholinergic Transmitter System in the Adult Mouse
Toxicol. Sci. 2002 67: 104-107; doi:10.1093/toxsci/67.1.104 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jonas Tallkvist, Eva Persson, Jörgen Henriksson, and Hans Tjälve

Cadmium-Metallothionein Interactions in the Olfactory Pathways of Rats and Pikes
Toxicol. Sci. 2002 67: 108-113; doi:10.1093/toxsci/67.1.108 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hailan Wang, Gaku Ichihara, Hidenori Ito, Kanefusa Kato, Junzoh Kitoh, Tetsuya Yamada, Xiaozhong Yu, Seiji Tsuboi, Yoshinori Moriyama, Rie Sakatani, Eiji Shibata, Michihiro Kamijima, Seiichiro Itohara, and Yasuhiro Takeuchi

Biochemical Changes in the Central Nervous System of Rats Exposed to 1-Bromopropane for Seven Days
Toxicol. Sci. 2002 67: 114-120; doi:10.1093/toxsci/67.1.114 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Gerald T. Ankley, Michael D. Kahl, Kathleen M. Jensen, Michael W. Hornung, Joseph J. Korte, Elizabeth A. Makynen, and Richard L. Leino

Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas)
Toxicol. Sci. 2002 67: 121-130; doi:10.1093/toxsci/67.1.121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Michael G. Wade, Warren G. Foster, Edward V. Younglai, Avril McMahon, Karen Leingartner, Al Yagminas, David Blakey, Michel Fournier, Daniel Desaulniers, and Claude L. Hughes

Effects of Subchronic Exposure to a Complex Mixture of Persistent Contaminants in Male Rats: Systemic, Immune, and Reproductive Effects
Toxicol. Sci. 2002 67: 131-143; doi:10.1093/toxsci/67.1.131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

T. R. Hanley, Jr., W. J. Breslin, J. F. Quast, and E. W. Carney

Evaluation of Spinosad in a Two-Generation Dietary Reproduction Study Using Sprague-Dawley Rats
Toxicol. Sci. 2002 67: 144-152; doi:10.1093/toxsci/67.1.144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Gary M. Williams

Letter
Toxicol. Sci. 2002 67: 153; doi:10.1093/toxsci/67.1.153 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Hanspeter Witschi

Reply
Toxicol. Sci. 2002 67: 153; doi:10.1093/toxsci/67.1.153-a [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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