Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Kevin T. Morgan

Gene Expression Analysis Reveals Chemical-Specific Profiles
Toxicol. Sci. 2002 67: 155-156; doi:10.1093/toxsci/67.2.155 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Dale A. Stirling

Harvey W. Wiley
Toxicol. Sci. 2002 67: 157-158; doi:10.1093/toxsci/67.2.157 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Ramesh Sarangapani, Justin Teeguarden, Kathleen P. Plotzke, James M. McKim, Jr., and Melvin E. Andersen

Dose-Response Modeling of Cytochrome P450 Induction in Rats by Octamethylcyclotetrasiloxane
Toxicol. Sci. 2002 67: 159-172; doi:10.1093/toxsci/67.2.159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. N. Enongene, R. P. Sharma, N. Bhandari, J. D. Miller, F. I. Meredith, K. A. Voss, and R. T. Riley

Persistence and Reversibility of the Elevation in Free Sphingoid Bases Induced by Fumonisin Inhibition of Ceramide Synthase
Toxicol. Sci. 2002 67: 173-181; doi:10.1093/toxsci/67.2.173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David R. Johnson and Curtis D. Klaassen

Regulation of Rat Multidrug Resistance Protein 2 by Classes of Prototypical Microsomal Enzyme Inducers That Activate Distinct Transcription Pathways
Toxicol. Sci. 2002 67: 182-189; doi:10.1093/toxsci/67.2.182 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

R. Valentine, J. R. Bamberger, B. Szostek, S. R. Frame, J. F. Hansen, and M. S. Bogdanffy

Time- and Concentration-Dependent Increases in Cell Proliferation in Rats and Mice Administered Vinyl Acetate in Drinking Water
Toxicol. Sci. 2002 67: 190-197; doi:10.1093/toxsci/67.2.190 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

T. E. Stoker, D. L. Guidici, S. C. Laws, and R. L. Cooper

The Effects of Atrazine Metabolites on Puberty and Thyroid Function in the Male Wistar Rat
Toxicol. Sci. 2002 67: 198-206; doi:10.1093/toxsci/67.2.198 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael G. Wade, Sophie Parent, Kenneth W. Finnson, Warren Foster, Edward Younglai, Avril McMahon, Daniel G. Cyr, and Claude Hughes

Thyroid Toxicity Due to Subchronic Exposure to a Complex Mixture of 16 Organochlorines, Lead, and Cadmium
Toxicol. Sci. 2002 67: 207-218; doi:10.1093/toxsci/67.2.207 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Hisham K. Hamadeh, Pierre R. Bushel, Supriya Jayadev, Karla Martin, Olimpia DiSorbo, Stella Sieber, Lee Bennett, Raymond Tennant, Raymond Stoll, J. Carl Barrett, Kerry Blanchard, Richard S. Paules, and Cynthia A. Afshari

Gene Expression Analysis Reveals Chemical-Specific Profiles
Toxicol. Sci. 2002 67: 219-231; doi:10.1093/toxsci/67.2.219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hisham K. Hamadeh, Pierre R. Bushel, Supriya Jayadev, Olimpia DiSorbo, Lee Bennett, Leping Li, Raymond Tennant, Raymond Stoll, J. Carl Barrett, Richard S. Paules, Kerry Blanchard, and Cynthia A. Afshari

Prediction of Compound Signature Using High Density Gene Expression Profiling
Toxicol. Sci. 2002 67: 232-240; doi:10.1093/toxsci/67.2.232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eiko Koike, Seishiro Hirano, Nobuhiro Shimojo, and Takahiro Kobayashi

cDNA Microarray Analysis of Gene Expression in Rat Alveolar Macrophages in Response to Organic Extract of Diesel Exhaust Particles
Toxicol. Sci. 2002 67: 241-246; doi:10.1093/toxsci/67.2.241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Haizhou Zhang, Lisa M. Kamendulis, and James E. Klaunig

Mechanisms for the Induction of Oxidative Stress in Syrian Hamster Embryo Cells by Acrylonitrile
Toxicol. Sci. 2002 67: 247-255; doi:10.1093/toxsci/67.2.247 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Yi-Ho Young, Jiunn-Jye Chuu, Shing-Hwa Liu, and Shoei-Yn Lin-Shiau

Neurotoxic Mechanism of Cinnabar and Mercuric Sulfide on the Vestibulo-Ocular Reflex System of Guinea Pigs
Toxicol. Sci. 2002 67: 256-263; doi:10.1093/toxsci/67.2.256 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Barry G. Timms, Richard E. Peterson, and Frederick S. vom Saal

2,3,7,8-Tetrachlorodibenzo-p-dioxin Interacts with Endogenous Estradiol to Disrupt Prostate Gland Morphogenesis in Male Rat Fetuses
Toxicol. Sci. 2002 67: 264-274; doi:10.1093/toxsci/67.2.264 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Alina Deshpande, Padma K. Narayanan, and Bruce E. Lehnert

Silica-Induced Generation of Extracellular Factor(s) Increases Reactive Oxygen Species in Human Bronchial Epithelial Cells
Toxicol. Sci. 2002 67: 275-283; doi:10.1093/toxsci/67.2.275 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James G. Wagner, Jon A. Hotchkiss, and Jack R. Harkema

Enhancement of Nasal Inflammatory and Epithelial Responses after Ozone and Allergen Coexposure in Brown Norway Rats
Toxicol. Sci. 2002 67: 284-294; doi:10.1093/toxsci/67.2.284 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael D. Taylor, Jenny R. Roberts, Ann F. Hubbs, Mark J. Reasor, and James M. Antonini

Quantitative Image Analysis of Drug-Induced Lung Fibrosis Using Laser Scanning Confocal Microscopy
Toxicol. Sci. 2002 67: 295-302; doi:10.1093/toxsci/67.2.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Stephen M. Roberts, William R. Weimar, J. R. T. Vinson, John W. Munson, and Raymond J. Bergeron

Measurement of Arsenic Bioavailability in Soil Using a Primate Model
Toxicol. Sci. 2002 67: 303-310; doi:10.1093/toxsci/67.2.303 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Russell L. Carr, Jason R. Richardson, John A. Guarisco, Anil Kachroo, Janice E. Chambers, Terrilyn A. Couch, Godwin C. Durunna, and Edward C. Meek

Effects of PCB Exposure on the Toxic Impact of Organophosphorus Insecticides
Toxicol. Sci. 2002 67: 311-321; doi:10.1093/toxsci/67.2.311 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jaspreet S. Gujral, Tamara R. Knight, Anwar Farhood, Mary Lynn Bajt, and Hartmut Jaeschke

Mode of Cell Death after Acetaminophen Overdose in Mice: Apoptosis or Oncotic Necrosis?
Toxicol. Sci. 2002 67: 322-328; doi:10.1093/toxsci/67.2.322 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eric B. Harstad and Curtis D. Klaassen

Analysis of Strain Difference in Sensitivity to Cadmium-Induced Hepatotoxicity in Fischer 344 and Sprague-Dawley Rats
Toxicol. Sci. 2002 67: 329-340; doi:10.1093/toxsci/67.2.329 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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