Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Randall J. Ruch

Intercellular Communication, Homeostasis, and Toxicology
Toxicol. Sci. 2002 68: 265-266; doi:10.1093/toxsci/68.2.265 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Hanspeter Witschi

John Morrison Barnes, 1913–1975
Toxicol. Sci. 2002 68: 267-269; doi:10.1093/toxsci/68.2.267 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Ruth A. Roberts

Evidence for Cross Talk between PPAR and p38 MAP Kinase
Toxicol. Sci. 2002 68: 270-274; doi:10.1093/toxsci/68.2.270 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

William J. Waddell

Thresholds of Carcinogenicity of Flavors
Toxicol. Sci. 2002 68: 275-279; doi:10.1093/toxsci/68.2.275 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Karla D. Thrall, Karl K. Weitz, and Angela D. Woodstock

Use of Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling to Evaluate Dermal Absorption of Aqueous Toluene in Human Volunteers
Toxicol. Sci. 2002 68: 280-287; doi:10.1093/toxsci/68.2.280 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jung D. Park, Nathan J. Cherrington, and Curtis D. Klaassen

Intestinal Absorption of Cadmium Is Associated with Divalent Metal Transporter 1 in Rats
Toxicol. Sci. 2002 68: 288-294; doi:10.1093/toxsci/68.2.288 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Michael E. Wyde, Theresa Cambre, Mark Lebetkin, Sandra R. Eldridge, and Nigel J. Walker

Promotion of Altered Hepatic Foci by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 17ß-estradiol in Male Sprague-Dawley Rats
Toxicol. Sci. 2002 68: 295-303; doi:10.1093/toxsci/68.2.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan Hasmall, George Orphanides, Neil James, William Pennie, Kathryn Hedley, Anthony Soames, Ian Kimber, and Ruth Roberts

Downregulation of Lactoferrin by PPAR Ligands: Role in Perturbation of Hepatocyte Proliferation and Apoptosis
Toxicol. Sci. 2002 68: 304-313; doi:10.1093/toxsci/68.2.304 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa A. Troester, Andrew B. Lindstrom, Suramya Waidyanatha, Lawrence L. Kupper, and Stephen M. Rappaport

Stability of Hemoglobin and Albumin Adducts of Naphthalene Oxide, 1,2-Naphthoquinone, and 1,4-Naphthoquinone
Toxicol. Sci. 2002 68: 314-321; doi:10.1093/toxsci/68.2.314 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hanspeter Witschi, Imelda Espiritu, Stephanie T. Dance, and Mark Steven Miller

A Mouse Lung Tumor Model of Tobacco Smoke Carcinogenesis
Toxicol. Sci. 2002 68: 322-330; doi:10.1093/toxsci/68.2.322 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charles A. Vaslet, Norma J. Messier, and Agnes B. Kane

Accelerated Progression of Asbestos-Induced Mesotheliomas in Heterozygous p53^+/- Mice
Toxicol. Sci. 2002 68: 331-338; doi:10.1093/toxsci/68.2.331 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

H. Tinwell, J. Haseman, P. A. Lefevre, N. Wallis, and J. Ashby

Normal Sexual Development of Two Strains of Rat Exposed in Utero to Low Doses of Bisphenol A
Toxicol. Sci. 2002 68: 339-348; doi:10.1093/toxsci/68.2.339 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Grantley D. Charles, C. Gennings, Timothy R. Zacharewski, B. Bhaskar Gollapudi, and Edward W. Carney

An Approach for Assessing Estrogen Receptor-Mediated Interactions in Mixtures of Three Chemicals: A Pilot Study
Toxicol. Sci. 2002 68: 349-360; doi:10.1093/toxsci/68.2.349 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ilonka A. T. M. Meerts, Yvonne Assink, Peter H. Cenijn, Johannes H. J. van den Berg, Bert M. Weijers, Åke Bergman, Jan H. Koeman, and Abraham Brouwer

Placental Transfer of a Hydroxylated Polychlorinated Biphenyl and Effects on Fetal and Maternal Thyroid Hormone Homeostasis in the Rat
Toxicol. Sci. 2002 68: 361-371; doi:10.1093/toxsci/68.2.361 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elena S. Craft, Michael J. DeVito, and Kevin M. Crofton

Comparative Responsiveness of Hypothyroxinemia and Hepatic Enzyme Induction in Long-Evans Rats Versus C57BL/6J Mice Exposed to TCDD-like and Phenobarbital-like Polychlorinated Biphenyl Congeners
Toxicol. Sci. 2002 68: 372-380; doi:10.1093/toxsci/68.2.372 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Abir T. El-Alfy and Daniel Schlenk

Effect of 17ß-Estradiol and Testosterone on the Expression of Flavin-Containing Monooxygenase and the Toxicity of Aldicarb to Japanese Medaka, Oryzias latipes
Toxicol. Sci. 2002 68: 381-388; doi:10.1093/toxsci/68.2.381 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christy M. Foran, Bethany N. Peterson, and William H. Benson

Transgenerational and Developmental Exposure of Japanese Medaka (Oryzias latipes) to Ethinylestradiol Results in Endocrine and Reproductive Differences in the Response to Ethinylestradiol as Adults
Toxicol. Sci. 2002 68: 389-402; doi:10.1093/toxsci/68.2.389 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eric A. Andreasen, Jan M. Spitsbergen, Robert L. Tanguay, John J. Stegeman, Warren Heideman, and Richard E. Peterson

Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure
Toxicol. Sci. 2002 68: 403-419; doi:10.1093/toxsci/68.2.403 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

G. Frank Gerberick, Lynn W. Cruse, Cindy A. Ryan, Ben C. Hulette, Joel G. Chaney, Robert A. Skinner, Rebecca J. Dearman, and Ian Kimber

Use of a B Cell Marker (B220) to Discriminate between Allergens and Irritants in the Local Lymph Node Assay
Toxicol. Sci. 2002 68: 420-428; doi:10.1093/toxsci/68.2.420 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Wenyue Hu, Paul D. Jones, Brad L. Upham, James E. Trosko, Christopher Lau, and John P. Giesy

Inhibition of Gap Junctional Intercellular Communication by Perfluorinated Compounds in Rat Liver and Dolphin Kidney Epithelial Cell Lines in Vitro and Sprague-Dawley Rats in Vivo
Toxicol. Sci. 2002 68: 429-436; doi:10.1093/toxsci/68.2.429 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lisa M. Kamendulis, Haizhou Zhang, Yanhong Wang, and James E. Klaunig

Morphological Transformation and Oxidative Stress Induced by Cyanide in Syrian Hamster Embryo (SHE) Cells
Toxicol. Sci. 2002 68: 437-443; doi:10.1093/toxsci/68.2.437 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rola Barhoumi, Youssef Mouneimne, Igbal Awooda, Stephen H. Safe, Kirby C. Donnelly, and Robert C. Burghardt

Characterization of Calcium Oscillations in Normal and Benzo[a]pyrene-Treated Clone 9 Cells
Toxicol. Sci. 2002 68: 444-450; doi:10.1093/toxsci/68.2.444 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Prasada Rao S. Kodavanti and Ethel C. Derr-Yellin

Differential Effects of Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls on [³H]Arachidonic Acid Release in Rat Cerebellar Granule Neurons
Toxicol. Sci. 2002 68: 451-457; doi:10.1093/toxsci/68.2.451 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert E. Lasky, John J. Widholm, Kevin M. Crofton, and Susan L. Schantz

Perinatal Exposure to Aroclor 1254 Impairs Distortion Product Otoacoustic Emissions (DPOAEs) in Rats
Toxicol. Sci. 2002 68: 458-464; doi:10.1093/toxsci/68.2.458 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Jennifer A. Loertscher, Tien-Min Lin, Richard E. Peterson, and B. Lynn Allen-Hoffmann

In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Accelerated Terminal Differentiation in Fetal Mouse Skin
Toxicol. Sci. 2002 68: 465-472; doi:10.1093/toxsci/68.2.465 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. Borgeest, D. Symonds, L. P. Mayer, P. B. Hoyer, and J. A. Flaws

Methoxychlor May Cause Ovarian Follicular Atresia and Proliferation of the Ovarian Epithelium in the Mouse
Toxicol. Sci. 2002 68: 473-478; doi:10.1093/toxsci/68.2.473 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tien-Min Lin, Kinarm Ko, Robert W. Moore, Ulla Simanainen, Terry D. Oberley, and Richard E. Peterson

Effects of Aryl Hydrocarbon Receptor Null Mutation and in Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on Prostate and Seminal Vesicle Development in C57BL/6 Mice
Toxicol. Sci. 2002 68: 479-487; doi:10.1093/toxsci/68.2.479 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Mang Yu, Xiaomu Zheng, Hanspeter Witschi, and Kent E. Pinkerton

The Role of Interleukin-6 in Pulmonary Inflammation and Injury Induced by Exposure to Environmental Air Pollutants
Toxicol. Sci. 2002 68: 488-497; doi:10.1093/toxsci/68.2.488 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Steven Trohalaki, Robert J. Zellmer, Ruth Pachter, Saber M. Hussain, and John M. Frazier

Risk Assessment of High-Energy Chemicals by in Vitro Toxicity Screening and Quantitative Structure-Activity Relationships
Toxicol. Sci. 2002 68: 498-507; doi:10.1093/toxsci/68.2.498 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Melissa K. Lingohr, Richard J. Bull, Junko Kato-Weinstein, and Brian D. Thrall

Dichloroacetate Stimulates Glycogen Accumulation in Primary Hepatocytes through an Insulin-Independent Mechanism
Toxicol. Sci. 2002 68: 508-515; doi:10.1093/toxsci/68.2.508 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Gerald P. Schoenig

Letter
Toxicol. Sci. 2002 68: 516-517; doi:10.1093/toxsci/68.2.516 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

M. B. Abou-Donia, L. B. Goldstein, and W. A. Khan

Reply
Toxicol. Sci. 2002 68: 517-519; doi:10.1093/toxsci/68.2.517 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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