Toxicol. Sci. -- Table of Contents (69 1)

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Contents: September 2002; Volume 69, Number 1   [Index by Author]

       TOXICOLOGICAL HIGHLIGHT

       BIOTRANSFORMATION AND TOXICOKINETICS

       CARCINOGENICITY

       ENDOCRINE TOXICOLOGY

       IMMUNOTOXICOLOGY

       IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

       MOLECULAR AND GENETIC TOXICOLOGY

       NEUROTOXICOLOGY

       REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

       RESPIRATORY TOXICOLOGY

       SAFETY EVALUATION

       SYSTEMS TOXICOLOGY

       LETTERS TO THE EDITOR

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TOXICOLOGICAL HIGHLIGHT:

Donald E. Tillitt and Diana M. Papoulias: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis
Toxicol. Sci. 2002 69: 1-2; doi:10.1093/toxsci/69.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

BIOTRANSFORMATION AND TOXICOKINETICS:

J. E. Simmons, W. K. Boyes, P. J. Bushnell, J. H. Raymer, T. Limsakun, A. McDonald, Y. M. Sey, and M. V. Evans: A Physiologically Based Pharmacokinetic Model for Trichloroethylene in the Male Long-Evans Rat
Toxicol. Sci. 2002 69: 3-15; doi:10.1093/toxsci/69.1.3 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

CARCINOGENICITY:

Carmen E. Perrone, Kyoko C. Takahashi, and Gary M. Williams: Inhibition of Human Topoisomerase II ${alpha}$ by Fluoroquinolones and Ultraviolet A Irradiation
Toxicol. Sci. 2002 69: 16-22; doi:10.1093/toxsci/69.1.16 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Ute C. Obermueller-Jevic, Imelda Espiritu, Ana M. Corbacho, Carroll E. Cross, and Hanspeter Witschi: Lung Tumor Development in Mice Exposed to Tobacco Smoke and Fed ß-Carotene Diets
Toxicol. Sci. 2002 69: 23-29; doi:10.1093/toxsci/69.1.23 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Gordon C. Hard: Significance of the Renal Effects of Ethyl Benzene in Rodents for Assessing Human Carcinogenic Risk
Toxicol. Sci. 2002 69: 30-41; doi:10.1093/toxsci/69.1.30 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Karen L. Porter, Sanjay Chanda, Hui Quin Wang, Kevin W. Gaido, Robert C. Smart, and C. Lee Robinette: 17ß-Estradiol Is a Hormonal Regulator of Mirex Tumor Promotion Sensitivity in Mice
Toxicol. Sci. 2002 69: 42-48; doi:10.1093/toxsci/69.1.42 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

ENDOCRINE TOXICOLOGY:

John C. Rockett, Robert J. Kavlock, Christy R. Lambright, Louise G. Parks, Judith E. Schmid, Vickie S. Wilson, Carmen Wood, and David J. Dix: DNA Arrays to Monitor Gene Expression in Rat Blood and Uterus following 17ß-Estradiol Exposure: Biomonitoring Environmental Effects Using Surrogate Tissues
Toxicol. Sci. 2002 69: 49-59; doi:10.1093/toxsci/69.1.49 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

David R. Plowchalk and Justin Teeguarden: Development of a Physiologically Based Pharmacokinetic Model for Estradiol in Rats and Humans: A Biologically Motivated Quantitative Framework for Evaluating Responses to Estradiol and Other Endocrine-Active Compounds
Toxicol. Sci. 2002 69: 60-78; doi:10.1093/toxsci/69.1.60 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

John C. O’Connor, Steven R. Frame, and Gregory S. Ladics: Evaluation of a 15-Day Screening Assay Using Intact Male Rats for Identifying Steroid Biosynthesis Inhibitors and Thyroid Modulators
Toxicol. Sci. 2002 69: 79-91; doi:10.1093/toxsci/69.1.79 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

John C. O'Connor, Steven R. Frame, and Gregory S. Ladics: Evaluation of a 15-Day Screening Assay Using Intact Male Rats for Identifying Antiandrogens
Toxicol. Sci. 2002 69: 92-108; doi:10.1093/toxsci/69.1.92 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

IMMUNOTOXICOLOGY:

Robert W. Luebke, Carey B. Copeland, Lisa R. Bishop, Mary J. Daniels, and M. Ian Gilmour: Mortality in Dioxin-Exposed Mice Infected with Influenza: Mitochondrial Toxicity (Reye's-Like Syndrome) Versus Enhanced Inflammation as the Mode of Action
Toxicol. Sci. 2002 69: 109-116; doi:10.1093/toxsci/69.1.109 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Michael D. Laiosa, Zhi-Wei Lai, T. Scott Thurmond, Nancy C. Fiore, Charles DeRossi, Bernadette C. Holdener, Thomas A. Gasiewicz, and Allen E. Silverstone: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2
Toxicol. Sci. 2002 69: 117-124; doi:10.1093/toxsci/69.1.117 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Peter A. Behnisch, Kazunori Hosoe, Abraham Brouwer, and Shin-ichi Sakai: Screening of Dioxin-Like Toxicity Equivalents for Various Matrices with Wildtype and Recombinant Rat Hepatoma H4IIE Cells
Toxicol. Sci. 2002 69: 125-130; doi:10.1093/toxsci/69.1.125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

MOLECULAR AND GENETIC TOXICOLOGY:

Mark A. Tirmenstein, Catherine X. Hu, Tracy L. Gales, Beverly E. Maleeff, Padma K. Narayanan, Edit Kurali, Timothy K. Hart, Heath C. Thomas, and Lester W. Schwartz: Effects of Troglitazone on HepG2 Viability and Mitochondrial Function
Toxicol. Sci. 2002 69: 131-138; doi:10.1093/toxsci/69.1.131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Michelle L. O'Brien, Michael L. Cunningham, Brett T. Spear, and Howard P. Glauert: Peroxisome Proliferators Do Not Activate the Transcription Factors AP-1, Early Growth Response-1, or Heat Shock Factors 1 and 2 in Rats or Hamsters
Toxicol. Sci. 2002 69: 139-148; doi:10.1093/toxsci/69.1.139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Liuji Chen, Xianqiang Yang, Hongli Jiao, and Baolu Zhao: Tea Catechins Protect against Lead-Induced Cytotoxicity, Lipid Peroxidation, and Membrane Fluidity in HepG2 Cells
Toxicol. Sci. 2002 69: 149-156; doi:10.1093/toxsci/69.1.149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

NEUROTOXICOLOGY:

Xun Song, Hailin Tian, Joseph Bressler, Stephen Pruett, and Carey Pope: Acute and Repeated Restraint Stress Have Little Effect on Pyridostigmine Toxicity or Brain Regional Cholinesterase Inhibition in Rats
Toxicol. Sci. 2002 69: 157-164; doi:10.1093/toxsci/69.1.157 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Julia D. George, Catherine J. Price, Melissa C. Marr, Christina B. Myers, and Gloria D. Jahnke: Evaluation of the Developmental Toxicity of Formamide in New Zealand White Rabbits
Toxicol. Sci. 2002 69: 165-174; doi:10.1093/toxsci/69.1.165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Liane M. Correa, Masaaki Nakai, Christina S. Strandgaard, Rex A. Hess, and Marion G. Miller: Microtubules of the Mouse Testis Exhibit Differential Sensitivity to the Microtubule Disruptors Carbendazim and Colchicine
Toxicol. Sci. 2002 69: 175-182; doi:10.1093/toxsci/69.1.175 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Raviprakash R. Dugyala, Thomas W. Claggett, Gary L. Kimmel, and Carole A. Kimmel: HSP90 ${alpha}$ , HSP90ß, and p53 Expression following in Vitro Hyperthermia Exposure in Gestation Day 10 Rat Embryos
Toxicol. Sci. 2002 69: 183-190; doi:10.1093/toxsci/69.1.183 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Wu Dong, Hiroki Teraoka, Koji Yamazaki, Shusaku Tsukiyama, Sumiko Imani, Tomohiro Imagawa, John J. Stegeman, Richard E. Peterson, and T. Hiraga: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis
Toxicol. Sci. 2002 69: 191-201; doi:10.1093/toxsci/69.1.191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Tien-Min Lin, Ulla Simanainen, Robert W. Moore, and Richard E. Peterson: Critical Windows of Vulnerability for Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Prostate and Seminal Vesicle Development in C57BL/6 Mice
Toxicol. Sci. 2002 69: 202-209; doi:10.1093/toxsci/69.1.202 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

RESPIRATORY TOXICOLOGY:

Martin Pelletier, Valérie Lavastre, and Denis Girard: Activation of Human Epithelial Lung A549 Cells by the Pollutant Sodium Sulfite: Enhancement of Neutrophil Adhesion
Toxicol. Sci. 2002 69: 210-216; doi:10.1093/toxsci/69.1.210 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Lin Ji, Goar Melkonian, Karen Riveles, and Prue Talbot: Identification of Pyridine Compounds in Cigarette Smoke Solution That Inhibit Growth of the Chick Chorioallantoic Membrane
Toxicol. Sci. 2002 69: 217-225; doi:10.1093/toxsci/69.1.217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

SAFETY EVALUATION:

Chi-Chung Chou, Jim E. Riviere, and Nancy A. Monteiro-Riviere: Differential Relationship between the Carbon Chain Length of Jet Fuel Aliphatic Hydrocarbons and Their Ability to Induce Cytotoxicity vs. Interleukin-8 Release in Human Epidermal Keratinocytes
Toxicol. Sci. 2002 69: 226-233; doi:10.1093/toxsci/69.1.226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

M. R. Hejtmancik, B. A. Trela, P. J. Kurtz, R. L. Persing, M. J. Ryan, J. T. Yarrington, and R. S. Chhabra: Comparative Gavage Subchronic Toxicity Studies of o-Chloroaniline and m-Chloroaniline in F344 Rats and B6C3F1 Mice
Toxicol. Sci. 2002 69: 234-243; doi:10.1093/toxsci/69.1.234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

John Butenhoff, Giovanni Costa, Cliff Elcombe, David Farrar, Kristin Hansen, Hiroyuki Iwai, Reinhard Jung, Gerald Kennedy, Jr., Paul Lieder, Geary Olsen, and Peter Thomford: Toxicity of Ammonium Perfluorooctanoate in Male Cynomolgus Monkeys after Oral Dosing for 6 Months
Toxicol. Sci. 2002 69: 244-257; doi:10.1093/toxsci/69.1.244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Mark M. Udden: In Vitro Sub-Hemolytic Effects of Butoxyacetic Acid on Human and Rat Erythrocytes
Toxicol. Sci. 2002 69: 258-264; doi:10.1093/toxsci/69.1.258 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

Carr J. Smith, Thomas A. Perfetti, Michael J. Morton, Alan Rodgman, Rajni Garg, Cynthia D. Selassie, and Corwin Hansch: The Relative Toxicity of Substituted Phenols Reported in Cigarette Mainstream Smoke
Toxicol. Sci. 2002 69: 265-278; doi:10.1093/toxsci/69.1.265 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

SYSTEMS TOXICOLOGY:

Lynette K. Rogers, Sanjiv Gupta, Stephen E. Welty, Thomas N. Hansen, and Charles V. Smith: Nuclear and Nucleolar Glutathione Reductase, Peroxidase, and Transferase Activities in Livers of Male and Female Fischer-344 Rats
Toxicol. Sci. 2002 69: 279-285; doi:10.1093/toxsci/69.1.279 [Abstract] [FREE Full Text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR:

Edward J. Calabrese: Letter
Toxicol. Sci. 2002 69: 286; doi:10.1093/toxsci/69.1.286 [Extract] [FREE Full Text] [PDF] [Request Permissions]

Michael Wade: Reply
Toxicol. Sci. 2002 69: 286-287; doi:10.1093/toxsci/69.1.286-a [Extract] [FREE Full Text] [PDF] [Request Permissions]

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