Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Jeffrey D. Laskin, Diane E. Heck, and Debra L. Laskin

The Ribotoxic Stress Response as a Potential Mechanism for MAP Kinase Activation in Xenobiotic Toxicity
Toxicol. Sci. 2002 69: 289-291; doi:10.1093/toxsci/69.2.289 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY:

Lutz W. Weber

Georgius Agricola (1494–1555): Scholar, Physician, Scientist, Entrepreneur, Diplomat
Toxicol. Sci. 2002 69: 292-294; doi:10.1093/toxsci/69.2.292 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOGENETICS:

Ronald E. Baynes, James D. Brooks, Moiz Mumtaz, and Jim E. Riviere

Effect of Chemical Interactions in Pentachlorophenol Mixtures on Skin and Membrane Transport
Toxicol. Sci. 2002 69: 295-305; doi:10.1093/toxsci/69.2.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Hisham K. Hamadeh, Kevin J. Trouba, Rupesh P. Amin, Cynthia A. Afshari, and Dori Germolec

Coordination of Altered DNA Repair and Damage Pathways in Arsenite-Exposed Keratinocytes
Toxicol. Sci. 2002 69: 306-316; doi:10.1093/toxsci/69.2.306 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yoko Kashida, Yu F. Sasaki, Koh-ichi Ohsawa, Natsue Yokohama, Akiko Takahashi, Takao Watanabe, and Kunitoshi Mitsumori

Mechanistic Study on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice
Toxicol. Sci. 2002 69: 317-321; doi:10.1093/toxsci/69.2.317 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michelle J. Hooth, Kevin S. McDorman, Susan D. Hester, Michael H. George, Lance R. Brooks, Adam E. Swank, and Douglas C. Wolf

The Carcinogenic Response of Tsc2 Mutant Long-Evans (Eker) Rats to a Mixture of Drinking Water Disinfection By-Products Was Less Than Additive
Toxicol. Sci. 2002 69: 322-331; doi:10.1093/toxsci/69.2.322 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Susan Y. Euling, Chris Gennings, Elizabeth M. Wilson, Jon A. Kemppainen, William R. Kelce, and Carole A. Kimmel

Response-Surface Modeling of the Effect of 5-Dihydrotestosterone and Androgen Receptor Levels on the Response to the Androgen Antagonist Vinclozolin
Toxicol. Sci. 2002 69: 332-343; doi:10.1093/toxsci/69.2.332 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anne Marie Vinggaard, Christine Nellemann, Majken Dalgaard, Eva Bonefeld Jørgensen, and Helle Raun Andersen

Antiandrogenic Effects in Vitro and in Vivo of the Fungicide Prochloraz
Toxicol. Sci. 2002 69: 344-353; doi:10.1093/toxsci/69.2.344 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. G. Goodin, K. C. Fertuck, T. R. Zacharewski, and R. J. Rosengren

Estrogen Receptor-Mediated Actions of Polyphenolic Catechins in Vivo and in Vitro
Toxicol. Sci. 2002 69: 354-361; doi:10.1093/toxsci/69.2.354 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Robert J. Letcher, Josephine G. Lemmen, Bart van der Burg, Abraham Brouwer, Åke Bergman, John P. Giesy, and Martin van den Berg

In Vitro Antiestrogenic Effects of Aryl Methyl Sulfone Metabolites of Polychlorinated Biphenyls and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene on 17ß-Estradiol-Induced Gene Expression in Several Bioassay Systems
Toxicol. Sci. 2002 69: 362-372; doi:10.1093/toxsci/69.2.362 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Yuseok Moon and James J. Pestka

Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases
Toxicol. Sci. 2002 69: 373-382; doi:10.1093/toxsci/69.2.373 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jiang Li, Matthew Pankratz, and Jeffrey A. Johnson

Differential Gene Expression Patterns Revealed by Oligonucleotide Versus Long cDNA Arrays
Toxicol. Sci. 2002 69: 383-390; doi:10.1093/toxsci/69.2.383 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

G. L. Kimmel, P. L. Williams, T. W. Claggett, and C. A. Kimmel

Response-Surface Analysis of Exposure-Duration Relationships: The Effects of Hyperthermia on Embryonic Development of the Rat in Vitro
Toxicol. Sci. 2002 69: 391-399; doi:10.1093/toxsci/69.2.391 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Deepak K. Bhalla, Paul G. Reinhart, Cheng Bai, and Suresh K. Gupta

Amelioration of Ozone-Induced Lung Injury by Anti-Tumor Necrosis Factor-
Toxicol. Sci. 2002 69: 400-408; doi:10.1093/toxsci/69.2.400 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeanelle M. Martinez, Cynthia A. Afshari, Pierre R. Bushel, Akira Masuda, Takashi Takahashi, and Nigel J. Walker

Differential Toxicogenomic Responses to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Malignant and Nonmalignant Human Airway Epithelial Cells
Toxicol. Sci. 2002 69: 409-423; doi:10.1093/toxsci/69.2.409 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Saber M. Hussain and John M. Frazier

Cellular Toxicity of Hydrazine in Primary Rat Hepatocytes
Toxicol. Sci. 2002 69: 424-432; doi:10.1093/toxsci/69.2.424 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

I. Malerba, A. F. Castoldi, D. Parent-Massin, and L. Gribaldo

In Vitro Myelotoxicity of Propanil and 3,4-Dichloroaniline on Murine and Human CFU-E/BFU-E Progenitors
Toxicol. Sci. 2002 69: 433-438; doi:10.1093/toxsci/69.2.433 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charles T. Eason and Patricia Turck

A 90-Day Toxicological Evaluation of Compound 1080 (Sodium Monofluoroacetate) in Sprague-Dawley Rats
Toxicol. Sci. 2002 69: 439-447; doi:10.1093/toxsci/69.2.439 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Udayan M. Apte, Pallavi B. Limaye, Shashi K. Ramaiah, Vishal S. Vaidya, Thomas J. Bucci, Alan Warbritton, and Harihara M. Mehendale

Upregulated Promitogenic Signaling via Cytokines and Growth Factors: Potential Mechanism of Robust Liver Tissue Repair in Calorie-Restricted Rats upon Toxic Challenge
Toxicol. Sci. 2002 69: 448-459; doi:10.1093/toxsci/69.2.448 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Armando Soto, Brent D. Foy, and John M. Frazier

Effect of Cadmium on Bromosulfophthalein Kinetics in the Isolated Perfused Rat Liver System
Toxicol. Sci. 2002 69: 460-469; doi:10.1093/toxsci/69.2.460 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shawn Kinser, Bryan L. Copple, Robert A. Roth, and Patricia E. Ganey

Enhancement of Allyl Alcohol Hepatotoxicity by Endotoxin Requires Extrahepatic Factors
Toxicol. Sci. 2002 69: 470-481; doi:10.1093/toxsci/69.2.470 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anu Kiukkonen, Matti Viluksela, Carin Sahlberg, Satu Alaluusua, Jouni T. Tuomisto, Jouko Tuomisto, and Pirjo-Liisa Lukinmaa

Response of the Incisor Tooth to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in a Dioxin-Resistant and a Dioxin-Sensitive Rat Strain
Toxicol. Sci. 2002 69: 482-489; doi:10.1093/toxsci/69.2.482 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.