Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael P. Waalkes and Jie Liu

Purine Nucleoside Phosphorylase: A Fortuitous Cytosolic Arsenate Reductase?
Toxicol. Sci. 2002 70: 1-3; doi:10.1093/toxsci/70.1.1 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Balázs Németi and Zoltán Gregus

Reduction of Arsenate to Arsenite in Hepatic Cytosol
Toxicol. Sci. 2002 70: 4-12; doi:10.1093/toxsci/70.1.4 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zoltán Gregus and Balázs Németi

Purine Nucleoside Phosphorylase as a Cytosolic Arsenate Reductase
Toxicol. Sci. 2002 70: 13-19; doi:10.1093/toxsci/70.1.13 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charles Wang, Theo K. Bammler, and David L. Eaton

Complementary DNA Cloning, Protein Expression, and Characterization of Alpha-Class GSTs from Macaca fascicularis Liver
Toxicol. Sci. 2002 70: 20-26; doi:10.1093/toxsci/70.1.20 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Corike Toxopeus and J. M. Frazier

Simulation of Trichloroacetic Acid Kinetics in the Isolated Perfused Rat Liver Using a Biologically Based Kinetic Model
Toxicol. Sci. 2002 70: 27-39; doi:10.1093/toxsci/70.1.27 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

J. Craig Rowlands, Reza Hakkak, Martin J. J. Ronis, and Thomas M. Badger

Altered Mammary Gland Differentiation and Progesterone Receptor Expression in Rats Fed Soy and Whey Proteins
Toxicol. Sci. 2002 70: 40-45; doi:10.1093/toxsci/70.1.40 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Tomohiro Ito, Kaoru Inouye, Hidekazu Fujimaki, Chiharu Tohyama, and Keiko Nohara

Mechanism of TCDD-Induced Suppression of Antibody Production: Effect on T Cell-Derived Cytokine Production in the Primary Immune Reaction of Mice
Toxicol. Sci. 2002 70: 46-54; doi:10.1093/toxsci/70.1.46 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Umesh M. Hanumegowda, Vamsidhara C. Dhulipala, and Chada S. Reddy

Mechanism of Secalonic Acid D-Induced Inhibition of Transcription Factor Binding to Cyclic AMP Response Element in the Developing Murine Palate
Toxicol. Sci. 2002 70: 55-62; doi:10.1093/toxsci/70.1.55 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yoonkyung Do, Seongho Ryu, Mitzi Nagarkatti, and Prakash S. Nagarkatti

Role of Death Receptor Pathway in Estradiol-Induced T-Cell Apoptosis in Vivo
Toxicol. Sci. 2002 70: 63-72; doi:10.1093/toxsci/70.1.63 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Urmila P. Kodavanti, Mette C. J. Schladweiler, Allen D. Ledbetter, Russ Hauser, David C. Christiani, James M. Samet, John McGee, Judy H. Richards, and Daniel L. Costa

Pulmonary and Systemic Effects of Zinc-Containing Emission Particles in Three Rat Strains: Multiple Exposure Scenarios
Toxicol. Sci. 2002 70: 73-85; doi:10.1093/toxsci/70.1.73 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Edilberto Bermudez, James B. Mangum, Bahman Asgharian, Brian A. Wong, Edward E. Reverdy, Derek B. Janszen, Paul M. Hext, David B. Warheit, and Jeffrey I. Everitt

Long-Term Pulmonary Responses of Three Laboratory Rodent Species to Subchronic Inhalation of Pigmentary Titanium Dioxide Particles
Toxicol. Sci. 2002 70: 86-97; doi:10.1093/toxsci/70.1.86 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael E. Viana, Najwa Haykal Coates, Stephen H. Gavett, MaryJane K. Selgrade, Stephen J. Vesper, and Marsha D. W. Ward

An Extract of Stachybotrys chartarum Causes Allergic Asthma-like Responses in a BALB/c Mouse Model
Toxicol. Sci. 2002 70: 98-109; doi:10.1093/toxsci/70.1.98 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James M. Antonini, Jenny R. Roberts, Michael R. Jernigan, Hui-Min Yang, Jane Y. C. Ma, and Robert W. Clarke

Residual Oil Fly Ash Increases the Susceptibility to Infection and Severely Damages the Lungs after Pulmonary Challenge with a Bacterial Pathogen
Toxicol. Sci. 2002 70: 110-119; doi:10.1093/toxsci/70.1.110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

P. Robinan Gentry, C. Eric Hack, Lynne Haber, Andrew Maier, and Harvey J. Clewell, III

An Approach for the Quantitative Consideration of Genetic Polymorphism Data in Chemical Risk Assessment: Examples with Warfarin and Parathion
Toxicol. Sci. 2002 70: 120-139; doi:10.1093/toxsci/70.1.120 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

A. O. Gamer, R. Jaeckh, E. Leibold, W. Kaufmann, C. Gembardt, R. Bahnemann, and B. van Ravenzwaay

Investigations on Cell Proliferation and Enzyme Induction in Male Rat Kidney and Female Mouse Liver Caused by Tetrahydrofuran
Toxicol. Sci. 2002 70: 140-149; doi:10.1093/toxsci/70.1.140 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Byung-Il Yoon, Yoko Hirabayashi, Yasushi Kawasaki, Yukio Kodama, Toyozo Kaneko, Jun Kanno, Dae-Yong Kim, Yoshiaki Fujii-Kuriyama, and Tohru Inoue

Aryl Hydrocarbon Receptor Mediates Benzene-Induced Hematotoxicity
Toxicol. Sci. 2002 70: 150-156; doi:10.1093/toxsci/70.1.150 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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