Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Jeffrey W. Fisher

PBPK Modeling Advances Understanding of D₄ Pharmacokinetics
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 1-2; doi:10.1093/toxsci/kfg020 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Micaela B. Reddy, Melvin E. Andersen, Paul E. Morrow, Ivan D. Dobrev, Sudarsanan Varaprath, Kathleen P. Plotzke, and Mark J. Utell

Physiological Modeling of Inhalation Kinetics of Octamethylcyclotetrasiloxane in Humans during Rest and Exercise
ToxSci Advance Access published on January 31, 2003
Toxicol. Sci. 2003 72: 3-18; doi:10.1093/toxsci/kfg001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

N. J. DelRaso, B. D. Foy, J. M. Gearhart, and J. M. Frazier

Cadmium Uptake Kinetics in Rat Hepatocytes: Correction for Albumin Binding
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 19-30; doi:10.1093/toxsci/kfg009 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Ann de Peyster, Kathryn J. MacLean, Beth A. Stephens, Lisa D. Ahern, Christian M. Westover, and Diana Rozenshteyn

Subchronic Studies in Sprague-Dawley Rats to Investigate Mechanisms of MTBE-Induced Leydig Cell Cancer
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 31-42; doi:10.1093/toxsci/kfg011 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven B. Yee, Umesh M. Hanumegowda, Jon A. Hotchkiss, Patricia E. Ganey, and Robert A. Roth

Role of Neutrophils in the Synergistic Liver Injury from Monocrotaline and Bacterial Lipopolysaccharide Exposure
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 43-56; doi:10.1093/toxsci/kfg019 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Janet Dowdy, Stacey Brower, and Michael R. Miller

Acetaminophen Exhibits Weak Antiestrogenic Activity in Human Endometrial Adenocarcinoma (Ishikawa) Cells
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 57-65; doi:10.1093/toxsci/kfg005 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

P. K. Schmieder, M. A. Tapper, R. C. Kolanczyk, D. E. Hammermeister, B. R. Sheedy, and J. S. Denny

Discriminating Redox Cycling and Arylation Pathways of Reactive Chemical Toxicity in Trout Hepatocytes
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 66-76; doi:10.1093/toxsci/kfg016 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Duane B. Huggett, Christy M. Foran, Bryan W. Brooks, Jim Weston, Bethany Peterson, K. Erica Marsh, Thomas W. La Point, and Daniel Schlenk

Comparison of in Vitro and in Vivo Bioassays for Estrogenicity in Effluent from North American Municipal Wastewater Facilities
ToxSci Advance Access published on January 31, 2003
Toxicol. Sci. 2003 72: 77-83; doi:10.1093/toxsci/kfg017 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Ruriko Sakai, Teruyuki Kajiume, Hiroko Inoue, Rieko Kanno, Masaki Miyazaki, Yuichi Ninomiya, and Masamoto Kanno

TCDD Treatment Eliminates the Long-Term Reconstitution Activity of Hematopoietic Stem Cells
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 84-91; doi:10.1093/toxsci/kfg002 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Haiyan Xu, David Dinsdale, Benoit Nemery, and Peter H.M. Hoet

Role of Residual Additives in the Cytotoxicity and Cytokine Release Caused by Polyvinyl Chloride Particles in Pulmonary Cell Cultures
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 92-102; doi:10.1093/toxsci/kfg003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Beth A. Vorderstrasse, Erica A. Dearstyne, and Nancy I. Kerkvliet

Influence of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antigen-Presenting Activity of Dendritic Cells
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 103-112; doi:10.1093/toxsci/kfg012 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wumin Dong, MaryJane K. Selgrade, and M. Ian Gilmour

Systemic Administration of Bordetella pertussis Enhances Pulmonary Sensitization to House Dust Mite in Juvenile Rats
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 113-121; doi:10.1093/toxsci/kfg015 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Sébastien Perrot, Hélène Dutertre-Catella, Chantal Martin, Patrice Rat, and Jean-Michel Warnet

Resazurin Metabolism Assay Is a New Sensitive Alternative Test in Isolated Pig Cornea
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 122-129; doi:10.1093/toxsci/kfg014 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

MOLECULAR AND GENETIC TOXICOLOGY:

Hui-Ren Zhou, Zahidul Islam, and James J. Pestka

Rapid, Sequential Activation of Mitogen-Activated Protein Kinases and Transcription Factors Precedes Proinflammatory Cytokine mRNA Expression in Spleens of Mice Exposed to the Trichothecene Vomitoxin
ToxSci Advance Access published on January 31, 2003
Toxicol. Sci. 2003 72: 130-142; doi:10.1093/toxsci/kfg006 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Louise M. Winn

Homologous Recombination Initiated by Benzene Metabolites: A Potential Role of Oxidative Stress
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 143-149; doi:10.1093/toxsci/kfg008 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Gloria S. Pryhuber, Heidie L. Huyck, Raymond Baggs, Günter Oberdörster, and Jacob N. Finkelstein

Induction of Chemokines by Low-Dose Intratracheal Silica Is Reduced in TNFR I (p55) Null Mice
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 150-157; doi:10.1093/toxsci/kfg018 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

William J. Waddell

Thresholds of Carcinogenicity in the ED01 Study
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 158-163; doi:10.1093/toxsci/kfg004 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Koichi Goto, Yoshikazu Ishii, Toshimasa Jindo, and Kazuhisa Furuhama

Effect of Nefiracetam, a Neurotransmission Enhancer, on Primary Uroepithelial Cells of the Canine Urinary Bladder
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 164-170; doi:10.1093/toxsci/kfg010 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

James P. Luyendyk, Bryan L. Copple, Charles C. Barton, Patricia E. Ganey, and Robert A. Roth

Augmentation of Aflatoxin B₁ Hepatotoxicity by Endotoxin: Involvement of Endothelium and the Coagulation System
ToxSci Advance Access published on February 18, 2003
Toxicol. Sci. 2003 72: 171-181; doi:10.1093/toxsci/kfg007 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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