Toxicological Sciences

EDITORIAL:

James T. MacGregor

SNPs and Chips: Genomic Data in Safety Evaluation and Risk Assessment
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 207-208; doi:10.1093/toxsci/kfg099 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Michael L. Cunningham, Matthew S. Bogdanffy, Timothy R. Zacharewski, and Ronald N. Hines

Workshop Overview: Use of Genomic Data in Risk Assessment
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 209-215; doi:10.1093/toxsci/kfg071 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Peter L. Goering

The Road to Elucidating the Mechanism of Manganese-Bilirubin–Induced Cholestasis
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 73: 216-219; doi:10.1093/toxsci/kfg112 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Kartik Shankar, Vishal S. Vaidya, Udayan M. Apte, Jose E. Manautou, Martin J. J. Ronis, Thomas J. Bucci, and Harihara M. Mehendale

Type 1 Diabetic Mice Are Protected from Acetaminophen Hepatotoxicity
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 220-234; doi:10.1093/toxsci/kfg059 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rebecca A. Clewell, Elaine A. Merrill, Kyung O. Yu, Deirdre A. Mahle, Teresa R. Sterner, David R. Mattie, Peter J. Robinson, Jeffrey W. Fisher, and Jeffery M. Gearhart

Predicting Fetal Perchlorate Dose and Inhibition of Iodide Kinetics during Gestation: A Physiologically-Based Pharmacokinetic Analysis of Perchlorate and Iodide Kinetics in the Rat
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 235-255; doi:10.1093/toxsci/kfg081 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elaine A. Merrill, Rebecca A. Clewell, Jeffery M. Gearhart, Peter J. Robinson, Teresa R. Sterner, Kyung O. Yu, David R. Mattie, and Jeffrey W. Fisher

PBPK Predictions of Perchlorate Distribution and Its Effect on Thyroid Uptake of Radioiodide in the Male Rat
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 256-269; doi:10.1093/toxsci/kfg080 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Diederik K. Van Sassenbroeck, Peter De Paepe, Frans M. Belpaire, and Walter A. Buylaert

Characterization of the Pharmacokinetic and Pharmacodynamic Interaction between Gamma-Hydroxybutyrate and Ethanol in the Rat
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 270-278; doi:10.1093/toxsci/kfg079 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Charlene A. McQueen and Binh Chau

Neonatal Ontogeny of Murine Arylamine N-Acetyltransferases: Implications for Arylamine Genotoxicity
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 279-286; doi:10.1093/toxsci/kfg086 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Tamotsu Takizawa, Kunitoshi Mitsumori, Toru Tamura, Masahiro Nasu, Makoto Ueda, Toshio Imai, and Masao Hirose

Hepatocellular Tumor Induction in Heterozygous p53-Deficient CBA Mice by a 26-Week Dietary Administration of Kojic Acid
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 287-293; doi:10.1093/toxsci/kfg094 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ryuya Shimoda, William E. Achanzar, Wei Qu, Takeaki Nagamine, Hitoshi Takagi, Masatomo Mori, and Michael P. Waalkes

Metallothionein Is a Potential Negative Regulator of Apoptosis
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 294-300; doi:10.1093/toxsci/kfg095 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ying C. Ou, Rory B. Conolly, Russell S. Thomas, Daniel L. Gustafson, Michael E. Long, Ivan D. Dobrev, Laura S. Chubb, Yihua Xu, Smadar A. Lapidot, Melvin E. Andersen, and Raymond S. H. Yang

Stochastic Simulation of Hepatic Preneoplastic Foci Development for Four Chlorobenzene Congeners in a Medium-Term Bioassay
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 301-314; doi:10.1093/toxsci/kfg078 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Anke Lühe, Heinz Hildebrand, Ute Bach, Theodor Dingermann, and Hans-Jürgen Ahr

A New Approach to Studying Ochratoxin A (OTA)-Induced Nephrotoxicity: Expression Profiling in Vivo and in Vitro Employing cDNA Microarrays
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 315-328; doi:10.1093/toxsci/kfg073 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rene E. Sotomayor, Melissa Washington, Linh Nguyen, Rahma Nyang’anyi, Dennis M. Hinton, and Ming Chou

Effects of Intermittent Exposure to Aflatoxin B₁ on DNA and RNA Adduct Formation in Rat Liver: Dose-Response and Temporal Patterns
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 329-338; doi:10.1093/toxsci/kfg076 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Etsuko Ueta, Yuko Tadokoro, Tomoko Yamamoto, Chiyuki Yamane, Emiko Suzuki, Eiji Nanba, Yuzuru Otsuka, and Tadao Kurata

The Effect of Cigarette Smoke Exposure and Ascorbic Acid Intake on Gene Expression of Antioxidant Enzymes and Other Related Enzymes in the Livers and Lungs of Shionogi Rats with Osteogenic Disorders
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 339-347; doi:10.1093/toxsci/kfg082 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sabu Kuruvilla, Charles W. Qualls, Jr., Ronald D. Tyler, Sam M. Witherspoon, Gina R. Benavides, Lawrence W. Yoon, Karen Dold, Roger H. Brown, Subbiah Sangiah, and Kevin T. Morgan

Effects of Minimally Toxic Levels of Carbonyl Cyanide P-(Trifluoromethoxy) Phenylhydrazone (FCCP), Elucidated through Differential Gene Expression with Biochemical and Morphological Correlations
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 348-361; doi:10.1093/toxsci/kfg084 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Dennis M. Hinton, Michael J. Myers, Richard A. Raybourne, Sabine Francke-Carroll, Rene E. Sotomayor, Joseph Shaddock, Alan Warbritton, and Ming W. Chou

Immunotoxicity of Aflatoxin B₁ in Rats: Effects on Lymphocytes and the Inflammatory Response in a Chronic Intermittent Dosing Study
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 362-377; doi:10.1093/toxsci/kfg074 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Marie-Yvonne Akoume, Shahid Perwaiz, Ibrahim M. Yousef, and Gabriel L. Plaa

Synergistic Role of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Cholesterol 7-Hydroxylase in the Pathogenesis of Manganese-Bilirubin–Induced Cholestasis in Rats
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 378-385; doi:10.1093/toxsci/kfg054 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Franziska Boess, Markus Kamber, Simona Romer, Rodolfo Gasser, Dieter Muller, Silvio Albertini, and Laura Suter

Gene Expression in Two Hepatic Cell Lines, Cultured Primary Hepatocytes, and Liver Slices Compared to the in Vivo Liver Gene Expression in Rats: Possible Implications for Toxicogenomics Use of in Vitro Systems
ToxSci Advance Access published on March 25, 2003
Toxicol. Sci. 2003 73: 386-402; doi:10.1093/toxsci/kfg064 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Jaimie E. Graff and David W. Herr

Disassociation of Carbon Disulfide-Induced Depression of Flash-Evoked Potential Peak N₁₆₆ Amplitude and Norepinephrine Levels
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 403-415; doi:10.1093/toxsci/kfg072 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiro-aki Yamamoto and Parayanthala V. Mohanan

In Vivo and in Vitro Effects of Melatonin or Ganglioside GT1B on L-Cysteine–Induced Brain Mitochondrial DNA Damage in Mice
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 416-422; doi:10.1093/toxsci/kfg089 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Ellen A. Cannady, Cheryl A. Dyer, Patricia J. Christian, I. Glenn Sipes, and Patricia B. Hoyer

Expression and Activity of Cytochromes P450 2E1, 2A, and 2B in the Mouse Ovary: The Effect of 4-Vinylcyclohexene and Its Diepoxide Metabolite
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 423-430; doi:10.1093/toxsci/kfg077 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Norman J. Barlow, Suzanne L. Phillips, Duncan G. Wallace, Madhabananda Sar, Kevin W. Gaido, and Paul M. D. Foster

Quantitative Changes in Gene Expression in Fetal Rat Testes following Exposure to Di(n-butyl) Phthalate
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 431-441; doi:10.1093/toxsci/kfg087 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tyra M. Leazer, George P. Daston, Carl L. Keen, and John M. Rogers

The Embryolethality of Lipopolysaccharide in CD-1 and Metallothionein I–II Null Mice: Lack of a Role for Induced Zinc Deficiency or Metallothionein Induction
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 442-447; doi:10.1093/toxsci/kfg088 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Werner Hofmann and Bahman Asgharian

The Effect of Lung Structure on Mucociliary Clearance and Particle Retention in Human and Rat Lungs
ToxSci Advance Access published on April 15, 2003
Toxicol. Sci. 2003 73: 448-456; doi:10.1093/toxsci/kfg075 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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