Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Lawrence H. Lash

The Mitochondrial Benzodiazepine Receptor as a Potential Target Protein for Drug Development: Demonstration of Functional Significance with Cell Lines Exhibiting Differential Expression of Bcl-2
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 1-3; doi:10.1093/toxsci/kfg140 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Pierluigi Nicotera

Molecular Switches Deciding the Death of Injured Neurons
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 4-9; doi:10.1093/toxsci/kfg109 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Dustin A. Leibelt, Olaf R. Hedstrom, Kay A. Fischer, Clifford B. Pereira, and David E. Williams

Evaluation of Chronic Dietary Exposure to Indole-3-Carbinol and Absorption-Enhanced 3,3'-Diindolylmethane in Sprague-Dawley Rats
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 10-21; doi:10.1093/toxsci/kfg103 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Balázs Németi, Iván Csanaky, and Zoltán Gregus

Arsenate Reduction in Human Erythrocytes and Rats—Testing the Role of Purine Nucleoside Phosphorylase
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 22-31; doi:10.1093/toxsci/kfg116 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Dong-Soon Bae, Robert J. Handa, Raymond S. H. Yang, and Julie A. Campain

Gene Expression Patterns as Potential Molecular Biomarkers for Malignant Transformation in Human Keratinocytes Treated with MNNG, Arsenic, or a Metal Mixture
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 32-42; doi:10.1093/toxsci/kfg124 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Risheng Ma, Bea Cotton, Walter Lichtensteiger, and Margret Schlumpf

UV Filters with Antagonistic Action at Androgen Receptors in the MDA-kb2 Cell Transcriptional-Activation Assay
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 43-50; doi:10.1093/toxsci/kfg102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Ken D. Oakes, Mark E. McMaster, Andrea C. Pryce, Kelly R. Munkittrick, Cam B. Portt, L. Mark Hewitt, Dan D. MacLean, and Glen J. Van Der Kraak

Oxidative Stress and Bioindicators of Reproductive Function in Pulp and Paper Mill Effluent Exposed White Sucker
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 51-65; doi:10.1093/toxsci/kfg114 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Donna E. Muscarella, Kerry A. O’Brien, Ann T. Lemley, and Stephen E. Bloom

Reversal of Bcl-2–Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite- and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 66-73; doi:10.1093/toxsci/kfg052 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kristen A. Mitchell and B. Paige Lawrence

Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Renders Influenza Virus-Specific CD8⁺ T Cells Hyporesponsive to Antigen
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 74-84; doi:10.1093/toxsci/kfg110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Todd J. Page, Scott O’Brien, Karrie Holston, Peter S. MacWilliams, Colin R. Jefcoate, and Charles J. Czuprynski

7,12-Dimethylbenz[a]anthracene-Induced Bone Marrow Toxicity Is p53-Dependent
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 85-92; doi:10.1093/toxsci/kfg115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zahidul Islam and James J. Pestka

Role of IL-1ß in Endotoxin Potentiation of Deoxynivalenol-Induced Corticosterone Response and Leukocyte Apoptosis in Mice
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 93-102; doi:10.1093/toxsci/kfg119 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Mari S. Golub, Casey E. Hogrefe, Stacey L. Germann, Bill L. Lasley, Kala Natarajan, and Alice F. Tarantal

Effects of Exogenous Estrogenic Agents on Pubertal Growth and Reproductive System Maturation in Female Rhesus Monkeys
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 103-113; doi:10.1093/toxsci/kfg090 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katie J. Turner, Barry S. McIntyre, Suzanne L. Phillips, Norman J. Barlow, Christopher J. Bowman, and Paul M. D. Foster

Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 114-128; doi:10.1093/toxsci/kfg096 [Abstract] [FREE Full Text] [PDF] Supplementary Tables [Request Permissions]  

J. Ashby, H. Tinwell, P. A. Lefevre, R. Joiner, and J. Haseman

The Effect on Sperm Production in Adult Sprague-Dawley Rats Exposed by Gavage to Bisphenol A between Postnatal Days 91–97
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 129-138; doi:10.1093/toxsci/kfg093 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sigmund J. Degitz, Gary W. Holcombe, Patricia A. Kosian, Joseph E. Tietge, Elizabeth J. Durhan, and Gerald T. Ankley

Comparing the Effects of Stage and Duration of Retinoic Acid Exposure on Amphibian Limb Development: Chronic Exposure Results in Mortality, Not Limb Malformations
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 139-146; doi:10.1093/toxsci/kfg098 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Patricia A. Kosian, Elizabeth A. Makynen, Gerald T. Ankley, and Sigmund J. Degitz

Uptake and Metabolism of All-trans Retinoic Acid by Three Native North American Ranids
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 147-156; doi:10.1093/toxsci/kfg100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert K. Vinson and Barbara F. Hales

Genotoxic Stress Response Gene Expression in the Mid-Organogenesis Rat Conceptus
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 157-164; doi:10.1093/toxsci/kfg097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Edilberto Bermudez, James B. Mangum, Owen R. Moss, Brian A. Wong, and Jeffrey I. Everitt

Pleural Dosimetry and Pathobiological Responses in Rats and Hamsters Exposed Subchronically to MMVF 10a Fiberglass
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 74: 165-173; doi:10.1093/toxsci/kfg092 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jie Liu, Dawei Lei, Michael P. Waalkes, Robert P. Beliles, and Daniel L. Morgan

Genomic Analysis of the Rat Lung following Elemental Mercury Vapor Exposure
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 174-181; doi:10.1093/toxsci/kfg091 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

J. T. Hamm, C.-Y. Chen, and L. S. Birnbaum

A Mixture of Dioxins, Furans, and Non-ortho PCBs Based upon Consensus Toxic Equivalency Factors Produces Dioxin-Like Reproductive Effects
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 182-191; doi:10.1093/toxsci/kfg107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Hoffman B. M. Lantum, Judith Cornejo, Robert H. Pierce, and M. W. Anders

Perturbation of Maleylacetoacetic Acid Metabolism in Rats with Dichloroacetic Acid-Induced Glutathione Transferase Zeta Deficiency
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 192-202; doi:10.1093/toxsci/kfg104 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven B. Yee, Umesh M. Hanumegowda, Bryan L. Copple, Masabumi Shibuya, Patricia E. Ganey, and Robert A. Roth

Endothelial Cell Injury and Coagulation System Activation during Synergistic Hepatotoxicity from Monocrotaline and Bacterial Lipopolysaccharide Coexposure
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 203-214; doi:10.1093/toxsci/kfg106 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vishal S. Vaidya, Kartik Shankar, Edward A. Lock, Thomas J. Bucci, and Harihara M. Mehendale

Role of Tissue Repair in Survival from S-(1,2-Dichlorovinyl)-_L-Cysteine–Induced Acute Renal Tubular Necrosis in the Mouse
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 74: 215-227; doi:10.1093/toxsci/kfg111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Leslie Klevay

Letter
Toxicol. Sci. 2003 74: 228; doi:10.1093/toxsci/kfg130 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Urmila P. Kodavanti, Allen D. Ledbetter, Mette C. Schladweiler, Daniel L. Costa, Carolyn F. Moyer, Russ Hauser, David C. Christiani, and Abraham Nyska

Reply
Toxicol. Sci. 2003 74: 228-229; doi:10.1093/toxsci/kfg127 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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