Toxicological Sciences

REVIEW:

George Orphanides and Ian Kimber

Toxicogenetics: Applications and Opportunities
ToxSci Advance Access published on May 2, 2003
Toxicol. Sci. 2003 75: 1-6; doi:10.1093/toxsci/kfg101 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

E. Dybing and T. Sanner

Risk Assessment of Acrylamide in Foods
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 7-15; doi:10.1093/toxsci/kfg165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Giorgio Marrubini, Anna F. Castoldi, Teresa Coccini, and Luigi Manzo

Prolonged Ethanol Ingestion Enhances Benzene Myelotoxicity and Lowers Urinary Concentrations of Benzene Metabolite Levels in CD-1 Male Mice
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 16-24; doi:10.1093/toxsci/kfg163 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lavinia Cantoni, Marco Rozio, Alessandra Mangolini, Lisa Hauri, and Silvio Caccia

Hyperforin Contributes to the Hepatic CYP3A-Inducing Effect of Hypericum perforatum Extract in the Mouse
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 25-30; doi:10.1093/toxsci/kfg174 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Y. Domoradzki, K. A. Brzak, and C. M. Thornton

Hydrolysis Kinetics of Propylene Glycol Monomethyl Ether Acetate in Rats in Vivo and in Rat and Human Tissues in Vitro
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 31-39; doi:10.1093/toxsci/kfg177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Hyun Ju Lee, Soma Chattopadhyay, Eun-Yeung Gong, Ryun Sup Ahn, and Keesook Lee

Antiandrogenic Effects of Bisphenol A and Nonylphenol on the Function of Androgen Receptor
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 40-46; doi:10.1093/toxsci/kfg150 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Wangsun Choi, Sung Yong Eum, Yong Woo Lee, Bernhard Hennig, Larry W. Robertson, and Michal Toborek

PCB 104-Induced Proinflammatory Reactions in Human Vascular Endothelial Cells: Relationship to Cancer Metastasis and Atherogenesis
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 47-56; doi:10.1093/toxsci/kfg149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sascha Pawlowski, Thomas Ternes, Martin Bonerz, Tatjana Kluczka, Bart van der Burg, Heinz Nau, Lothar Erdinger, and Thomas Braunbeck

Combined in Situ and in Vitro Assessment of the Estrogenic Activity of Sewage and Surface Water Samples
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 57-65; doi:10.1093/toxsci/kfg162 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hui-Ping Tzeng, Rong-Sen Yang, Tzuu-Huei Ueng, Shoei-Yn Lin-Shiau, and Shing-Hwa Liu

Motorcycle Exhaust Particulates Enhance Vasoconstriction in Organ Culture of Rat Aortas and Involve Reactive Oxygen Species
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 66-73; doi:10.1093/toxsci/kfg164 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Susan L. Starcevic, Nicole M. Diotte, Kim L. Zukowski, Mark J. Cameron, and Raymond F. Novak

Oxidative DNA Damage and Repair in a Cell Lineage Model of Human Proliferative Breast Disease (PBD)
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 74-81; doi:10.1093/toxsci/kfg154 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xuming Jia and Wei Xiao

Compromised DNA Repair Enhances Sensitivity of the Yeast RNR3-lacZ Genotoxicity Testing System
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 82-88; doi:10.1093/toxsci/kfg158 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

K. J. Klink and B. J. Meade

Dermal Exposure to 3-Amino-5-mercapto-1,2,4-triazole (AMT) Induces Sensitization and Airway Hyperreactivity in BALB/c Mice
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 89-98; doi:10.1093/toxsci/kfg171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Y. Shou, L. Li, K. Prabhakaran, J. L. Borowitz, and G. E. Isom

p38 Mitogen-Activated Protein Kinase Regulates Bax Translocation in Cyanide-Induced Apoptosis
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 99-107; doi:10.1093/toxsci/kfg157 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lily Raveh, Rachel Brandeis, Eran Gilat, Giora Cohen, David Alkalay, Ishai Rabinovitz, Hagar Sonego, and Ben Avi Weissman

Anticholinergic and Antiglutamatergic Agents Protect against Soman-Induced Brain Damage and Cognitive Dysfunction
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 108-116; doi:10.1093/toxsci/kfg166 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Laurence D. Fechter, Sjaak F. L. Klis, Najeeb A. Shirwany, Toby G. Moore, and Deepa Bandi Rao

Acrylonitrile Produces Transient Cochlear Function Loss and Potentiates Permanent Noise-Induced Hearing Loss
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 117-123; doi:10.1093/toxsci/kfg169 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

T. A. Lewandowski, R. A. Ponce, J. S. Charleston, S. Hong, and E. M. Faustman

Effect of Methylmercury on Midbrain Cell Proliferation during Organogenesis: Potential Cross-Species Differences and Implications for Risk Assessment
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 124-133; doi:10.1093/toxsci/kfg151 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. L. Carmines, C. L. Gaworski, A. S. Faqi, and N. Rajendran

In Utero Exposure to 1R4F Reference Cigarette Smoke: Evaluation of Developmental Toxicity
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 134-147; doi:10.1093/toxsci/kfg155 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Aceng Ruyani, Sri Sudarwati, Lien A. Sutasurya, Sony H. Sumarsono, and Torsten Gloe

The Laminin Binding Protein p40 Is Involved in Inducing Limb Abnormality of Mouse Fetuses as the Effects of Methoxyacetic Acid Treatment
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 148-153; doi:10.1093/toxsci/kfg159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Britt-Marie Bäcklin, Carolina Bredhult, and Matts Olovsson

Proliferative Effects of Estradiol, Progesterone, and Two CB Congeners and Their Metabolites on Gray Seal (Halichoerus grypus) Uterine Myocytes in Vitro
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 154-160; doi:10.1093/toxsci/kfg161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Jay A. A. West, Laura S. Van Winkle, Dexter Morin, Chad A. Fleschner, Henry Jay Forman, and Charles G. Plopper

Repeated Inhalation Exposures to the Bioactivated Cytotoxicant Naphthalene (NA) Produce Airway-Specific Clara Cell Tolerance in Mice
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 161-168; doi:10.1093/toxsci/kfg156 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey W. Card, William J. Racz, James F. Brien, Solomon B. Margolin, and Thomas E. Massey

Differential Effects of Pirfenidone on Acute Pulmonary Injury and Ensuing Fibrosis in the Hamster Model of Amiodarone-Induced Pulmonary Toxicity
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 169-180; doi:10.1093/toxsci/kfg167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael D. Taylor, Jenny R. Roberts, Stephen S. Leonard, Xianglin Shi, and James M. Antonini

Effects of Welding Fumes of Differing Composition and Solubility on Free Radical Production and Acute Lung Injury and Inflammation in Rats
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 181-191; doi:10.1093/toxsci/kfg173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Yu-Mei Tan, Byron E. Butterworth, Michael L. Gargas, and Rory B. Conolly

Biologically Motivated Computational Modeling of Chloroform Cytolethality and Regenerative Cellular Proliferation
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 192-200; doi:10.1093/toxsci/kfg152 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Shunji Ueno, Takashige Kashimoto, Nobuyuki Susa, Yutaka Shiota, Masayuki Okuda, Ken-ichiro Mutoh, Fumio Hoshi, Kiyotaka Watanabe, Shuji Tsuda, Sadahiro Kawazoe, Takashi Suzuki, and Masayasu Sugiyama

Effects of Butyltin Compounds on Mitochondrial Respiration and Its Relation to Hepatotoxicity in Mice and Guinea Pigs
ToxSci Advance Access published on June 12, 2003
Toxicol. Sci. 2003 75: 201-207; doi:10.1093/toxsci/kfg153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bart A. Jessen, Jennifer S. Mullins, Ann de Peyster, and Gregory J. Stevens

Assessment of Hepatocytes and Liver Slices as in Vitro Test Systems to Predict in Vivo Gene Expression
ToxSci Advance Access published on June 27, 2003
Toxicol. Sci. 2003 75: 208-222; doi:10.1093/toxsci/kfg172 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Werner K. Lutz

Letter
Toxicol. Sci. 2003 75: 223; doi:10.1093/toxsci/kfg160 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

William J. Waddell

Reply
Toxicol. Sci. 2003 75: 223-224; doi:10.1093/toxsci/kfg175 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Karl K. Rozman

Letter
Toxicol. Sci. 2003 75: 224-225; doi:10.1093/toxsci/kfg176 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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