Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

John M. Rogers and Barbara D. Abbott

Screening for Developmental Toxicity of Tobacco Smoke Constituents
ToxSci Advance Access published on August 28, 2003
Toxicol. Sci. 2003 75: 227-228; doi:10.1093/toxsci/kfg215 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Ammie N. Carnell and Jay I. Goodman

The Long (LINEs) and the Short (SINEs) of It: Altered Methylation as a Precursor to Toxicity
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 75: 229-235; doi:10.1093/toxsci/kfg138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

James T. MacGregor

The Future of Regulatory Toxicology: Impact of the Biotechnology Revolution
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 236-248; doi:10.1093/toxsci/kfg197 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Melanie L. Barnhill, Marie V. M. Rosemond, and Lawrence R. Curtis

Dieldrin Stimulates Biliary Excretion of ¹⁴C-Benzo[a]pyrene Polar Metabolites but Does Not Change the Biliary Metabolite Profile in Rainbow Trout (Oncorhyncus mykiss)
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 249-259; doi:10.1093/toxsci/kfg192 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan C. J. Sumner, Carla C. Williams, Rodney W. Snyder, Wojciech L. Krol, Bahman Asgharian, and Timothy R. Fennell

Acrylamide: A Comparison of Metabolism and Hemoglobin Adducts in Rodents following Dermal, Intraperitoneal, Oral, or Inhalation Exposure
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 260-270; doi:10.1093/toxsci/kfg191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Jinqiang Chen, Michael Delannoy, Shelly Odwin, Ping He, Michael A. Trush, and James D. Yager

Enhanced Mitochondrial Gene Transcript, ATP, Bcl-2 Protein Levels, and Altered Glutathione Distribution in Ethinyl Estradiol-Treated Cultured Female Rat Hepatocytes
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 271-278; doi:10.1093/toxsci/kfg183 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melva N. Ríos-Blanco, Shuji Yamaguchi, Mukta Dhawan-Robl, Winfried Kessler, Robert Schoonhoven, Johannes G. Filser, and James A. Swenberg

Effects of Propylene Oxide Exposure on Rat Nasal Respiratory Cell Proliferation
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 279-288; doi:10.1093/toxsci/kfg187 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rebecca E. Watson, Geoffrey M. Curtin, David J. Doolittle, and Jay I. Goodman

Progressive Alterations in Global and GC-Rich DNA Methylation during Tumorigenesis
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 289-299; doi:10.1093/toxsci/kfg190 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Job C. Tharappel, Aysegul Nalca, Aaron B. Owens, Leila Ghabrial, Elizabeth C. Konz, Howard P. Glauert, and Brett T. Spear

Cell Proliferation and Apoptosis Are Altered in Mice Deficient in the NF-B p50 Subunit after Treatment with the Peroxisome Proliferator Ciprofibrate
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 300-308; doi:10.1093/toxsci/kfg201 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Daniel Schlenk, Natalia Zubcov, and Elena Zubcov

Effects of Salinity on the Uptake, Biotransformation, and Toxicity of Dietary Seleno-L-Methionine to Rainbow Trout
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 309-313; doi:10.1093/toxsci/kfg184 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiroshi Masuno, Shoko Okamoto, Jun Iwanami, Katsuhisa Honda, Takahiko Shiosaka, Teruki Kidani, Kenshi Sakayama, and Haruyasu Yamamoto

Effect of 4-Nonylphenol on Cell Proliferation and Adipocyte Formation in Cultures of Fully Differentiated 3T3-L1 Cells
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 314-320; doi:10.1093/toxsci/kfg203 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Brenda Faiola, Alison K. Bauer, Elizabeth S. Fuller, Victoria A. Wong, Linda J. Pluta, Diane J. Abernethy, James B. Mangum, Jeffrey I. Everitt, and Leslie Recio

Variations in Prkdc and Susceptibility to Benzene-Induced Toxicity in Mice
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 321-332; doi:10.1093/toxsci/kfg186 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Robert B. Crawford, Courtney E. W. Sulentic, Byung S. Yoo, and Norbert E. Kaminski

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Regulation and Posttranslational Modification of p27^kip1 in Lipopolysaccharide-Activated B Cells
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 333-342; doi:10.1093/toxsci/kfg199 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Stephen B. Pruett, Ruping Fan, Qiang Zheng, L. Peyton Myers, and Pamela Hébert

Modeling and Predicting Immunological Effects of Chemical Stressors: Characterization of a Quantitative Biomarker for Immunological Changes Caused by Atrazine and Ethanol
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 343-354; doi:10.1093/toxsci/kfg200 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

A. Pessina, B. Albella, M. Bayo, J. Bueren, P. Brantom, S. Casati, C. Croera, G. Gagliardi, P. Foti, R. Parchment, D. Parent-Massin, G. Schoeters, Y. Sibiril, R. Van Den Heuvel, and L Gribaldo

Application of the CFU-GM Assay to Predict Acute Drug-Induced Neutropenia: An International Blind Trial to Validate a Prediction Model for the Maximum Tolerated Dose (MTD) of Myelosuppressive Xenobiotics
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 355-367; doi:10.1093/toxsci/kfg188 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David M. Barnes, Paul R. Hanlon, and Emily A. Kircher

Effects of Inorganic HgCl₂ on Adipogenesis
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 368-377; doi:10.1093/toxsci/kfg195 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Francoise de Longueville, Franck A. Atienzar, Laurence Marcq, Simon Dufrane, Stéphanie Evrard, Lydia Wouters, Florence Leroux, Vincent Bertholet, Brigitte Gerin, Rhys Whomsley, Thierry Arnould, José Remacle, and Mickael Canning

Use of a Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatotoxicants on Primary Cultures of Rat Hepatocytes
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 378-392; doi:10.1093/toxsci/kfg196 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Goar Melkonian, Holly Eckelhoefer, Melinda Wu, Yuhuan Wang, Cathy Tong, Karen Riveles, and Prue Talbot

Growth and Angiogenesis Are Inhibited in Vivo in Developing Tissues by Pyrazine and Its Derivatives
ToxSci Advance Access published on May 28, 2003
Toxicol. Sci. 2003 75: 393-401; doi:10.1093/toxsci/kfg123 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Masakuni Sawaki, Shuji Noda, Takako Muroi, Hideo Mitoma, Saori Takakura, Satoko Sakamoto, and Kanji Yamasaki

In Utero through Lactational Exposure to Ethinyl Estradiol Induces Cleft Phallus and Delayed Ovarian Dysfunction in the Offspring
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 402-411; doi:10.1093/toxsci/kfg180 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sandip Chattopadhyay, Sampa Pal (Ghosh), Debidas Ghosh, and Jogen Debnath

Effect of Dietary Co-Administration of Sodium Selenite on Sodium Arsenite-Induced Ovarian and Uterine Disorders in Mature Albino Rats
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 412-422; doi:10.1093/toxsci/kfg194 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

R. Clark Lantz, Jason Orozco, and Matthew S. Bogdanffy

Vinyl Acetate Decreases Intracellular pH in Rat Nasal Epithelial Cells
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 423-431; doi:10.1093/toxsci/kfg198 [Abstract] [FREE Full Text] [PDF] Supplementary Figures [Request Permissions]  

RISK ASSESSMENT:

Rory B. Conolly, Julia S. Kimbell, Derek Janszen, Paul M. Schlosser, Darin Kalisak, Julian Preston, and Frederick J. Miller

Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 75: 432-447; doi:10.1093/toxsci/kfg182 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

W. J. Brock, S. M. Munley, M. S. Swanson, K. M. McGown, and M. E. Hurtt

Developmental Toxicity and Genotoxicity Studies of 1,1,1,3,3,3-Hexachloropropane (HCC-230fa) in Rats
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 448-457; doi:10.1093/toxsci/kfg193 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Laura P. James, Sandra S. McCullough, Laura W. Lamps, and Jack A. Hinson

Effect of N-Acetylcysteine on Acetaminophen Toxicity in Mice: Relationship to Reactive Nitrogen and Cytokine Formation
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 458-467; doi:10.1093/toxsci/kfg181 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Desaulniers, K. Leingartner, B. Musicki, A. Yagminas, G.-H. Xiao, J. Cole, L. Marro, M. Charbonneau, and B. K. Tsang

Effects of Postnatal Exposure to Mixtures of Non-ortho-PCBs, PCDDs, and PCDFs in Prepubertal Female Rats
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 75: 468-480; doi:10.1093/toxsci/kfg189 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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