Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael J. McCabe, Jr.

Mechanisms and Consequences of Silica-Induced Apoptosis
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 1-2; doi:10.1093/toxsci/kfg246 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Justin E. Aldridge, Jennifer A. Gibbons, Meghan M. Flaherty, Marisa L. Kreider, Jocelyn A. Romano, and Edward D. Levin

Heterogeneity of Toxicant Response: Sources of Human Variability
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 76: 3-20; doi:10.1093/toxsci/kfg204 [Abstract] [FREE Full Text] [PDF] Supplementary tables [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

J. Y. Domoradzki, L. H. Pottenger, C. M. Thornton, S. C. Hansen, T. L. Card, D. A. Markham, M. D. Dryzga, R. N. Shiotsuka, and J. M. Waechter, Jr.

Metabolism and Pharmacokinetics of Bisphenol A (BPA) and the Embryo-Fetal Distribution of BPA and BPA-Monoglucuronide in CD Sprague-Dawley Rats at Three Gestational Stages
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 21-34; doi:10.1093/toxsci/kfg206 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Deborah A. Keys, James V. Bruckner, Srinivasa Muralidhara, and Jeffrey W. Fisher

Tissue Dosimetry Expansion and Cross-Validation of Rat and Mouse Physiologically Based Pharmacokinetic Models for Trichloroethylene
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 35-50; doi:10.1093/toxsci/kfg212 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shakil A. Saghir and Karl K. Rozman

Kinetics of Monochloroacetic Acid at Subtoxic and Toxic Doses in Rats after Single Oral and Dermal Administrations
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 51-64; doi:10.1093/toxsci/kfg214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. J. Johnson, V. Amarnath, K. Amarnath, H. Valentine, and W. M. Valentine

Characterizing the Influence of Structure and Route of Exposure on the Disposition of Dithiocarbamates Using Toluene-3,4-dithiol Analysis of Blood and Urinary Carbon Disulfide Metabolites
ToxSci Advance Access published on September 12, 2003
Toxicol. Sci. 2003 76: 65-74; doi:10.1093/toxsci/kfg226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Jiangang Chen, Gordon C. Douglas, Twanda L. Thirkill, Peter N. Lohstroh, Susan R. Bielmeier, Michael G. Narotsky, Deborah S. Best, Randy A. Harrison, Kala Natarajan, Rex A. Pegram, James W. Overstreet, and Bill L. Lasley

Effect of Bromodichloromethane on Chorionic Gonadotrophin Secretion by Human Placental Trophoblast Cultures
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 75-82; doi:10.1093/toxsci/kfg225 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Jing-Hsien Chen, Tsui-Hwa Tseng, Yung-Chyan Ho, Hui-Hsuan Lin, Wea-Lung Lin, and Chau-Jong Wang

Gaseous Nitrogen Oxides Stimulate Cell Cycle Progression by Rubidium Phosphorylation via Activation of Cyclins/Cdks
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 83-90; doi:10.1093/toxsci/kfg221 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

M. Thibodeau, C. Giardina, and A. K. Hubbard

Silica-Induced Caspase Activation in Mouse Alveolar Macrophages Is Dependent upon Mitochondrial Integrity and Aspartic Proteolysis
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2003 76: 91-101; doi:10.1093/toxsci/kfg178 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Miroslav Machala, Ludek Bláha, Jan Vondrácek, James E. Trosko, Jacob Scott, and Brad L. Upham

Inhibition of Gap Junctional Intercellular Communication by Noncoplanar Polychlorinated Biphenyls: Inhibitory Potencies and Screening for Potential Mode(s) of Action
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 102-111; doi:10.1093/toxsci/kfg209 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Henrik Viberg, Anders Fredriksson, Eva Jakobsson, Ulrika Örn, and Per Eriksson

Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain Development
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 112-120; doi:10.1093/toxsci/kfg210 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

William K. Boyes, Mark Bercegeay, Joseph S. Ali, Todd Krantz, John McGee, Marina Evans, James H. Raymer, Philip J. Bushnell, and Jane Ellen Simmons

Dose-Based Duration Adjustments for the Effects of Inhaled Trichloroethylene on Rat Visual Function
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 121-130; doi:10.1093/toxsci/kfg213 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yoffi Segall, Gary B. Quistad, Susan E. Sparks, Daniel K. Nomura, and John E. Casida

Toxicological and Structural Features of Organophosphorus and Organosulfur Cannabinoid CB1 Receptor Ligands
ToxSci Advance Access published on August 27, 2003
Toxicol. Sci. 2003 76: 131-137; doi:10.1093/toxsci/kfg216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Amy L. Prasch, Hiroki Teraoka, Sara A. Carney, Wu Dong, Takeo Hiraga, John J. Stegeman, Warren Heideman, and Richard E. Peterson

Aryl Hydrocarbon Receptor 2 Mediates 2,3,7,8-Tetrachlorodibenzo-p-dioxin Developmental Toxicity in Zebrafish
ToxSci Advance Access published on July 25, 2003
Toxicol. Sci. 2003 76: 138-150; doi:10.1093/toxsci/kfg202 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeanmarie M. Zodrow and Robert L. Tanguay

2,3,7,8-Tetrachlorodibenzo-p-dioxin Inhibits Zebrafish Caudal Fin Regeneration
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 151-161; doi:10.1093/toxsci/kfg205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Estíbaliz L. Fernández, Anne-Lee Gustafson, Maria Andersson, Bjorn Hellman, and Lennart Dencker

Cadmium-Induced Changes in Apoptotic Gene Expression Levels and DNA Damage in Mouse Embryos Are Blocked by Zinc
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 162-170; doi:10.1093/toxsci/kfg208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tien-Min Lin, Nathan T. Rasmussen, Robert W. Moore, Ralph M. Albrecht, and Richard E. Peterson

Region-Specific Inhibition of Prostatic Epithelial Bud Formation in the Urogenital Sinus of C57BL/6 Mice Exposed in Utero to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
ToxSci Advance Access published on August 27, 2003
Toxicol. Sci. 2003 76: 171-181; doi:10.1093/toxsci/kfg218 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Annie Hamel, Donna Mergler, Larissa Takser, Lucie Simoneau, and Julie Lafond

Effects of Low Concentrations of Organochlorine Compounds in Women on Calcium Transfer in Human Placental Syncytiotrophoblast
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 182-189; doi:10.1093/toxsci/kfg224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan C. Laws, Janet M. Ferrell, Tammy E. Stoker, and Ralph L. Cooper

Pubertal Development in Female Wistar Rats following Exposure to Propazine and Atrazine Biotransformation By-Products, Diamino-S-Chlorotriazine and Hydroxyatrazine
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 190-200; doi:10.1093/toxsci/kfg223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Husam S. Younis, Alan R. Parrish, and I. Glenn Sipes

The Role of Hepatocellular Oxidative Stress in Kupffer Cell Activation during 1,2-Dichlorobenzene-Induced Hepatotoxicity
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 201-211; doi:10.1093/toxsci/kfg207 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pachaikani Ramadass, Purushothaman Meerarani, Michal Toborek, Larry W. Robertson, and Bernhard Hennig

Dietary Flavonoids Modulate PCB-Induced Oxidative Stress, CYP1A1 Induction, and AhR-DNA Binding Activity in Vascular Endothelial Cells
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 212-219; doi:10.1093/toxsci/kfg227 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vsevolod E. Kostrubsky, Stephen C. Strom, Janean Hanson, Ellen Urda, Kelly Rose, James Burliegh, Philip Zocharski, Hongbo Cai, Jacqueline F. Sinclair, and Jasminder Sahi

Evaluation of Hepatotoxic Potential of Drugs by Inhibition of Bile-Acid Transport in Cultured Primary Human Hepatocytes and Intact Rats
ToxSci Advance Access published on August 27, 2003
Toxicol. Sci. 2003 76: 220-228; doi:10.1093/toxsci/kfg217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tamara R. Knight, Marc W. Fariss, Anwar Farhood, and Hartmut Jaeschke

Role of Lipid Peroxidation as a Mechanism of Liver Injury after Acetaminophen Overdose in Mice
ToxSci Advance Access published on August 27, 2003
Toxicol. Sci. 2003 76: 229-236; doi:10.1093/toxsci/kfg220 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Umesh M. Hanumegowda, Bryan L. Copple, Masabumi Shibuya, Ernst Malle, Patricia E. Ganey, and Robert A. Roth

Basement Membrane and Matrix Metalloproteinases in Monocrotaline-Induced Liver Injury
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 237-246; doi:10.1093/toxsci/kfg222 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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