Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Jerrold J. Heindel

Endocrine Disruptors and the Obesity Epidemic
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2003 76: 247-249; doi:10.1093/toxsci/kfg255 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Lawrence D. Middaugh, Diana Dow-Edwards, Abby A. Li, J. David Sandler, Jennifer Seed, Larry P. Sheets, Dana L. Shuey, William Slikker, Jr., Walter P. Weisenburger, L. David Wise, and Murray R. Selwyn

Neurobehavioral Assessment: A Survey of Use and Value in Safety Assessment Studies
ToxSci Advance Access published on August 12, 2003
Toxicol. Sci. 2003 76: 250-261; doi:10.1093/toxsci/kfg211 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Mette G. Goodin and Rhonda J. Rosengren

Epigallocatechin Gallate Modulates CYP450 Isoforms in the Female Swiss-Webster Mouse
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2003 76: 262-270; doi:10.1093/toxsci/kfh001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Nicole V. Soucy, Michael A. Ihnat, Chandrashekhar D. Kamat, Linda Hess, Mark J. Post, Linda R. Klei, Callie Clark, and Aaron Barchowsky

Arsenic Stimulates Angiogenesis and Tumorigenesis In Vivo
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 271-279; doi:10.1093/toxsci/kfg231 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. S. Perez, L. Armstrong-Lea, M. H. Fox, R. S. H. Yang, and J. A. Campain

Arsenic and Benzo[a]pyrene Differentially Alter the Capacity for Differentiation and Growth Properties of Primary Human Epidermal Keratinocytes
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 280-290; doi:10.1093/toxsci/kfg232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrea S. Randi, Susana Hernández, Laura Alvarez, Marcela Sánchez, Marta Schwarcz, and Diana L. Kleiman de Pisarev

Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and c-Jun Proto-Oncogenes in Rat Liver
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2003 76: 291-298; doi:10.1093/toxsci/kfg253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Ryoichi Kizu, Kazumasa Okamura, Akira Toriba, Atsushi Mizokami, Kerry L. Burnstein, Carolyn M. Klinge, and Kazuichi Hayakawa

Antiandrogenic Activities of Diesel Exhaust Particle Extracts in PC3/AR Human Prostate Carcinoma Cells
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 299-309; doi:10.1093/toxsci/kfg230 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Guosheng Chen and Nigel J. Bunce

Polybrominated Diphenyl Ethers as Ah Receptor Agonists and Antagonists
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 310-320; doi:10.1093/toxsci/kfg236 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

GENETIC TOXICOLOGY:

Hauh-Jyun Candy Chen, Chia-Liang Hong, Chan-Fu Wu, and Wei-Loong Chiu

Effect of Cigarette Smoking on Urinary 3,N⁴-Ethenocytosine Levels Measured by Gas Chromatography/Mass Spectrometry
ToxSci Advance Access published on August 27, 2003
Toxicol. Sci. 2003 76: 321-327; doi:10.1093/toxsci/kfg219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Yuansheng Tan, Daming Li, Renjie Song, David Lawrence, and David O. Carpenter

Ortho-Substituted PCBs Kill Thymocytes
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 328-337; doi:10.1093/toxsci/kfg233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeroen A. J. Vanoirbeek, Cindy Mandervelt, Albert R. Cunningham, Peter H. M. Hoet, Haiyan Xu, Hadewijch M. Vanhooren, and Benoit Nemery

Validity of Methods to Predict the Respiratory Sensitizing Potential of Chemicals: A Study with a Piperidinyl Chlorotriazine Derivative That Caused an Outbreak of Occupational Asthma
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 338-346; doi:10.1093/toxsci/kfg235 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Deborah E. Keil, D. Alan Warren, Matthew J. Jenny, Jackie G. EuDaly, Joshua Smythe, and Margie M. Peden-Adams

Immunological Function in Mice Exposed to JP-8 Jet Fuel In Utero
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 347-356; doi:10.1093/toxsci/kfg244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lenka L. Allan, Koren K. Mann, Raymond A. Matulka, Heui-Young Ryu, Jennifer J. Schlezinger, and David H. Sherr

Bone Marrow Stromal-B Cell Interactions in Polycyclic Aromatic Hydrocarbon-Induced Pro/Pre-B Cell Apoptosis
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 357-365; doi:10.1093/toxsci/kfg239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andrew A. Rooney, Raymond A. Matulka, and Robert W. Luebke

Developmental Atrazine Exposure Suppresses Immune Function in Male, but not Female Sprague-Dawley Rats
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 366-375; doi:10.1093/toxsci/kfg250 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Olga Teufelhofer, Rosa-Maria Weiss, Wolfram Parzefall, Rolf Schulte-Hermann, Michael Micksche, Walter Berger, and Leonilla Elbling

Promyelocytic HL60 Cells Express NADPH Oxidase and Are Excellent Targets in a Rapid Spectrophotometric Microplate Assay for Extracellular Superoxide
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 376-383; doi:10.1093/toxsci/kfg234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael H. Abraham, Mostafa Hassanisadi, Mehdi Jalali-Heravi, Taravat Ghafourian, William. S. Cain, and J. Enrique Cometto-Muñiz

Draize Rabbit Eye Test Compatibility with Eye Irritation Thresholds in Humans: A Quantitative Structure-Activity Relationship Analysis
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 384-391; doi:10.1093/toxsci/kfg242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Adrian Hill, C. Vyvyan Howard, Uwe Strahle, and Andrew Cossins

Neurodevelopmental Defects in Zebrafish (Danio rerio) at Environmentally Relevant Dioxin (TCDD) Concentrations
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2003 76: 392-399; doi:10.1093/toxsci/kfg241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jun Tang, Russell L. Carr, and Janice E. Chambers

The Effects of Repeated Oral Exposures to Methyl Parathion on Rat Brain Cholinesterase and Muscarinic Receptors during Postnatal Development
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 400-406; doi:10.1093/toxsci/kfg245 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

E. A. Thackaberry, E. J. Bedrick, M. B. Goens, L. Danielson, A. K. Lund, D. Gabaldon, S. M. Smith, and M. K. Walker

Insulin Regulation in AhR-null Mice: Embryonic Cardiac Enlargement, Neonatal Macrosomia, and Altered Insulin Regulation and Response in Pregnant and Aging AhR-null Females
ToxSci Advance Access published on September 11, 2003
Toxicol. Sci. 2003 76: 407-417; doi:10.1093/toxsci/kfg229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marvin L. Meistrich, Gene Wilson, Karen L. Porter, Ilpo Huhtaniemi, Gunapala Shetty, and Gladis A. Shuttlesworth

Restoration of Spermatogenesis in Dibromochloropropane (DBCP)-Treated Rats by Hormone Suppression
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 418-426; doi:10.1093/toxsci/kfg237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Barbara D. Abbott, Tien-Min Lin, Nathan T. Rasmussen, Ralph M. Albrecht, Judith E. Schmid, and Richard E. Peterson

Lack of Expression of EGF and TGF- in the Fetal Mouse Alters Formation of Prostatic Epithelial Buds and Influences the Response to TCDD
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2003 76: 427-436; doi:10.1093/toxsci/kfg238 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Robert L. Hamlin, Anusak Kijtawornrat, Bruce W. Keene, and David M. Hamlin

QT and RR Intervals in Conscious and Anesthetized Guinea Pigs with Highly Varying RR Intervals and Given QTc-Lengthening Test Articles
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2003 76: 437-442; doi:10.1093/toxsci/kfg254 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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