Toxicological Sciences

PROFILES IN TOXICOLOGY:

Joe LeBeau

Perry J. Gehring DVM, PhD (March 15, 1936–November 6, 2003)
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 77: 1-2; doi:10.1093/toxsci/kfh044 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Kevin L. Dreher

Health and Environmental Impact of Nanotechnology: Toxicological Assessment of Manufactured Nanoparticles
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 3-5; doi:10.1093/toxsci/kfh041 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Jeffrey A. Dill, Kyeonghee M. Lee, Kathleen H. Mellinger, Derrick J. Bates, Leo T. Burka, and Joseph H. Roycroft

Lung Deposition and Clearance of Inhaled Vanadium Pentoxide in Chronically Exposed F344 Rats and B6C3F1 Mice
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 6-18; doi:10.1093/toxsci/kfh005 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Heidrun Ellinger-Ziegelbauer, Barry Stuart, Brad Wahle, Werner Bomann, and Hans-Jürgen Ahr

Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 19-34; doi:10.1093/toxsci/kfh016 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Vinod Srivastava, Robert K. Dearth, Jill K. Hiney, Lisa M. Ramirez, Gerald R. Bratton, and W. Les Dees

The Effects of Low-level Pb on Steroidogenic Acute Regulatory Protein (StAR) in the Prepubertal Rat Ovary
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 35-40; doi:10.1093/toxsci/kfg249 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Houda Bilrha, Raynald Roy, Éric Wagner, Marthe Belles-Isles, Janice L. Bailey, and Pierre Ayotte

Effects of Gestational and Lactational Exposure to Organochlorine Compounds on Cellular, Humoral, and Innate Immunity in Swine
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 41-50; doi:10.1093/toxsci/kfg240 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Wayne J. Bowers, Jamie S. Nakai, Ih Chu, Michael G. Wade, David Moir, Al Yagminas, Santokh Gill, Olga Pulido, and Rudi Meuller

Early Developmental Neurotoxicity of a PCB/Organochlorine Mixture in Rodents after Gestational and Lactational Exposure
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 51-62; doi:10.1093/toxsci/kfg248 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Angela M. Betancourt and Russell L. Carr

The Effect of Chlorpyrifos and Chlorpyrifos-Oxon on Brain Cholinesterase, Muscarinic Receptor Binding, and Neurotrophin Levels in Rats Following Early Postnatal Exposure
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 63-71; doi:10.1093/toxsci/kfh003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Juliette Gafni, Patty W. Wong, and Isaac N. Pessah

Non-coplanar 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Amplifies Ionotropic Glutamate Receptor Signaling in Embryonic Cerebellar Granule Neurons by a Mechanism Involving Ryanodine Receptors
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 72-82; doi:10.1093/toxsci/kfh004 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jason R. Richardson and Janice E. Chambers

Neurochemical Effects of Repeated Gestational Exposure to Chlorpyrifos in Developing Rats
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 83-90; doi:10.1093/toxsci/kfh014 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Warren G. Foster, Edward V. Younglai, Odette Boutross-Tadross, Claude L. Hughes, and Michael G. Wade

Mammary Gland Morphology in Sprague-Dawley Rats following Treatment with an Organochlorine Mixture in Utero and Neonatal Genistein
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 91-100; doi:10.1093/toxsci/kfg247 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan R. Bielmeier, Deborah S. Best, and Michael G. Narotsky

Serum Hormone Characterization and Exogeneous Hormone Rescue of Bromodichloromethane-Induced Pregnancy Loss in the F344 Rat
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 101-108; doi:10.1093/toxsci/kfh017 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wu Dong, Hiroki Teraoka, Yoshikazu Tsujimoto, John J. Stegeman, and Takeo Hiraga

Role of Aryl Hydrocarbon Receptor in Mesencephalic Circulation Failure and Apoptosis in Zebrafish Embryos Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
ToxSci Advance Access published on December 3, 2003
Toxicol. Sci. 2004 77: 109-116; doi:10.1093/toxsci/kfh023 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Webb

Comparative Pulmonary Toxicity Assessment of Single-wall Carbon Nanotubes in Rats
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 117-125; doi:10.1093/toxsci/kfg228 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chiu-Wing Lam, John T. James, Richard McCluskey, and Robert L. Hunter

Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
ToxSci Advance Access published on September 26, 2003
Toxicol. Sci. 2004 77: 126-134; doi:10.1093/toxsci/kfg243 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gregory L. Baker, Michael A. Shultz, Michelle V. Fanucchi, Dexter M. Morin, Alan R. Buckpitt, and Charles G. Plopper

Assessing Gene Expression in Lung Subcompartments Utilizing In Situ RNA Preservation
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 135-141; doi:10.1093/toxsci/kfh002 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Raymond Poon, Marc Rigden, Ih Chu, and Victor E. Valli

Short-term Oral Toxicity of Pentyl Ether, 1,4-Diethoxybutane, and 1,6-Dimethoxyhexane in Male Rats
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 142-150; doi:10.1093/toxsci/kfg251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rory B. Conolly and Werner K. Lutz

Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 151-157; doi:10.1093/toxsci/kfh007 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

David W. Gaylor, Werner K. Lutz, and Rory B. Conolly

Statistical Analysis of Nonmonotonic Dose-Response Relationships: Research Design and Analysis of Nasal Cell Proliferation in Rats Exposed to Formaldehyde
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 158-164; doi:10.1093/toxsci/kfh008 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Sandrine Bouhet, Edith Hourcade, Nicolas Loiseau, Asmaa Fikry, Stéphanie Martinez, Marianna Roselli, Pierre Galtier, Elena Mengheri, and Isabelle P. Oswald

The Mycotoxin Fumonisin B₁ Alters the Proliferation and the Barrier Function of Porcine Intestinal Epithelial Cells
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 165-171; doi:10.1093/toxsci/kfh006 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bryan L. Copple, Catherine M. Rondelli, Jane F. Maddox, Niel C. Hoglen, Patricia E. Ganey, and Robert A. Roth

Modes of Cell Death in Rat Liver after Monocrotaline Exposure
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 172-182; doi:10.1093/toxsci/kfh011 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

S. Barone, Jr. and V. C. Moser

LETTER TO THE EDITOR
Toxicol. Sci. 2004 77: 183; doi:10.1093/toxsci/kfh036 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

ERRATUM
Toxicol. Sci. 2004 77: 0. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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