Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Janice E. Chambers and Seth F. Oppenheimer

Organophosphates, Serine Esterase Inhibition, and Modeling of Organophosphate Toxicity
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 77: 185-187; doi:10.1093/toxsci/kfh060 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

James MacDonald, John E. French, Ronald J. Gerson, Jay Goodman, Tohru Inoue, Abigail Jacobs, Peter Kasper, Douglas Keller, Amy Lavin, Gerald Long, Bruce McCullough, Frank D. Sistare, Richard Storer, and Jan Willem van der Laan

The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 188-194; doi:10.1093/toxsci/kfh037 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANFORMATION AND TOXICOKINETICS:

James Prah, David Ashley, Benjamin Blount, Martin Case, Teresa Leavens, Joachim Pleil, and Frederick Cardinali

Dermal, Oral, and Inhalation Pharmacokinetics of Methyl Tertiary Butyl Ether (MTBE) in Human Volunteers
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 195-205; doi:10.1093/toxsci/kfh009 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John W. Nichols, Patrick N. Fitzsimmons, Frank W. Whiteman, Timothy D. Dawson, Leo Babeu, and Jamie Juenemann

A Physiologically Based Toxicokinetic Model for Dietary Uptake of Hydrophobic Organic Compounds by Fish: I. Feeding Studies with 2,2',5,5'-Tetrachlorobiphenyl
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 206-218; doi:10.1093/toxsci/kfh033 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John W. Nichols, Patrick N. Fitzsimmons, and Frank W. Whiteman

A Physiologically Based Toxicokinetic Model for Dietary Uptake of Hydrophobic Organic Compounds by Fish: II. Simulation of Chronic Exposure Scenarios
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 219-229; doi:10.1093/toxsci/kfh032 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Y. Domoradzki, C. M. Thornton, L. H. Pottenger, S. C. Hansen, T. L. Card, D. A. Markham, M. D. Dryzga, R. N. Shiotsuka, and J. M. Waechter, Jr.

Age and Dose Dependency of the Pharmacokinetics and Metabolism of Bisphenol A in Neonatal Sprague-Dawley Rats Following Oral Administration
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 77: 230-242; doi:10.1093/toxsci/kfh054 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Michael A. Pereira, Wei Wang, Paula M. Kramer, and Lianhui Tao

Prevention by Methionine of Dichloroacetic Acid–Induced Liver Cancer and DNA Hypomethylation in Mice
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 243-248; doi:10.1093/toxsci/kfh031 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jie Liu, Yaxiong Xie, Jerrold M. Ward, Bhalchandra A. Diwan, and Michael P. Waalkes

Toxicogenomic Analysis of Aberrant Gene Expression in Liver Tumors and Nontumorous Livers of Adult Mice Exposed in utero to Inorganic Arsenic
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 77: 249-257; doi:10.1093/toxsci/kfh055 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

I. Petrikovics, D. Papahadjopoulos, K. Hong, T.-C. Cheng, S. I. Baskin, J. Jiang, J. C. Jaszberenyi, B. A. Logue, M. Szilasi, W. D. McGuinn, and J. L. Way

Comparing Therapeutic and Prophylactic Protection against the Lethal Effect of Paraoxon
ToxSci Advance Access published on July 11, 2003
Toxicol. Sci. 2004 77: 258-262; doi:10.1093/toxsci/kfg185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xuejun J. Yin, Caroline C. Dong, Jane Y. C. Ma, James M. Antonini, Jenny R. Roberts, Charles F. Stanley, Rosana Schafer, and Joseph K. H. Ma

Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 263-271; doi:10.1093/toxsci/kfh035 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Byung S. Yoo, Darrell R. Boverhof, Dina Shnaider, Robert B. Crawford, Timothy R. Zacharewski, and Norbert E. Kaminski

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Regulation of Pax5 in Lipopolysaccharide-Activated B Cells
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 272-279; doi:10.1093/toxsci/kfh013 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marcia Stickler, Narapon Rochanayon, O. Jennifer Razo, Jeanette Mucha, Wendy Gebel, Nargol Faravashi, Regina Chin, Susan Holmes, and Fiona A. Harding

An In Vitro Human Cell–Based Assay to Rank the Relative Immunogenicity of Proteins
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 77: 280-289; doi:10.1093/toxsci/kfh021 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jane F. Maddox, Alison C. Domzalski, Robert A. Roth, and Patricia E. Ganey

15-Deoxy Prostaglandin J₂ Enhances Allyl Alcohol–Induced Toxicity in Rat Hepatocytes
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 290-298; doi:10.1093/toxsci/kfh028 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

J.-S. Bolduc, F. Denizeau, and C. Jumarie

Cadmium-Induced Mitochondrial Membrane-Potential Dissipation Does Not Necessarily Require Cytosolic Oxidative Stress: Studies Using Rhodamine-123 Fluorescence Unquenching
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 299-306; doi:10.1093/toxsci/kfh015 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeanine A. Harrigan, Chad M. Vezina, Barbara P. McGarrigle, Noreen Ersing, Harold C. Box, Alexander E. Maccubbin, and James R. Olson

DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 77: 307-314; doi:10.1093/toxsci/kfh030 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Cindy S. Roegge, Victor C. Wang, Brian E. Powers, Anna Y. Klintsova, Sherilyn Villareal, William T. Greenough, and Susan L. Schantz

Motor Impairment in Rats Exposed to PCBs and Methylmercury during Early Development
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 315-324; doi:10.1093/toxsci/kfg252 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Martine Behra, Christelle Etard, Xavier Cousin, and Uwe Strähle

The Use of Zebrafish Mutants to Identify Secondary Target Effects of Acetylcholine Esterase Inhibitors
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 325-333; doi:10.1093/toxsci/kfh020 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jae Hoon Cheong, Desmond Bannon, Luisa Olivi, Yongbae Kim, and Joseph Bressler

Different Mechanisms Mediate Uptake of Lead in a Rat Astroglial Cell Line
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 77: 334-340; doi:10.1093/toxsci/kfh024 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven A. Burr and David E. Ray

Structure-Activity and Interaction Effects of 14 Different Pyrethroids on Voltage-Gated Chloride Ion Channels
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 341-346; doi:10.1093/toxsci/kfh027 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Edilberto Bermudez, James B. Mangum, Brian A. Wong, Bahman Asgharian, Paul M. Hext, David B. Warheit, and Jeffrey I. Everitt

Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 347-357; doi:10.1093/toxsci/kfh019 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Highlighted Article:

Yacov Ashani and Shlomi Pistinner

Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 77: 358-367; doi:10.1093/toxsci/kfh012 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

SAFETY EVALUATION:

Péter Sótonyi, Béla Merkely, Márta Hubay, Jeno Járay, Endre Zima, Pál Soós, Anikó Kovács, and István Szentmáriay

Comparative Study on Cardiotoxic Effect of Tinuvin 770: A Light Stabilizer of Medical Plastics in Rat Model
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 77: 368-374; doi:10.1093/toxsci/kfh025 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

ERRATUM
Toxicol. Sci. 2004 77: 374. [Extract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.