Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Matthew A. Wallig

Glucuronidation and Susceptibility to Chemical Carcinogenesis
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 1-2; doi:10.1093/toxsci/kfh068 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Walter H. Watson, Xianmei Yang, Young Eun Choi, Dean P. Jones, and James P. Kehrer

Thioredoxin and Its Role in Toxicology
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 3-14; doi:10.1093/toxsci/kfh050 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

C. Viau, C. Zaoui, and S. Charbonneau

Dietary Fibers Reduce the Urinary Excretion of 1-Hydroxypyrene following Intravenous Administration of Pyrene
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 15-19; doi:10.1093/toxsci/kfh052 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lester G. Sultatos, Gina M. Pastino, Clint A. Rosenfeld, and Edward J. Flynn

Incorporation of the Genetic Control of Alcohol Dehydrogenase into a Physiologically Based Pharmacokinetic Model for Ethanol in Humans
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 20-31; doi:10.1093/toxsci/kfh057 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Zhuohan Hu and Peter G. Wells

Human Interindividual Variation in Lymphocyte UDP-Glucuronosyltransferases as a Determinant of In Vitro Benzo[a]pyrene Covalent Binding and Cytotoxicity
ToxSci Advance Access published on November 4, 2003
Toxicol. Sci. 2004 78: 32-40; doi:10.1093/toxsci/kfh010 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

K. P. Lai, M. H. Wong, and Chris K. C. Wong

Modulation of AhR-Mediated CYP1A1 mRNA and EROD Activities by 17ß-Estradiol and Dexamethasone in TCDD-Induced H411E Cells
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 41-49; doi:10.1093/toxsci/kfh045 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shin'ichi Yoshihara, Tohru Mizutare, Misako Makishima, Noriko Suzuki, Nariaki Fujimoto, Kazuo Igarashi, and Shigeru Ohta

Potent Estrogenic Metabolites of Bisphenol A and Bisphenol B Formed by Rat Liver S9 Fraction: Their Structures and Estrogenic Potency
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 50-59; doi:10.1093/toxsci/kfh047 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Mace G. Barron, Mark G. Carls, Ron Heintz, and Stanley D. Rice

Evaluation of Fish Early Life-Stage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 60-67; doi:10.1093/toxsci/kfh051 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Amy L. Prasch, Eric A. Andreasen, Richard E. Peterson, and Warren Heideman

Interactions between 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Hypoxia Signaling Pathways in Zebrafish: Hypoxia Decreases Responses to TCDD in Zebrafish Embryos
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 68-77; doi:10.1093/toxsci/kfh053 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Adrian J. Hill, Susan M. Bello, Amy L. Prasch, Richard E. Peterson, and Warren Heideman

Water Permeability and TCDD-Induced Edema in Zebrafish Early-Life Stages
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 78-87; doi:10.1093/toxsci/kfh056 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Janine Ezendam, Ine Hassing, Rob Bleumink, Joseph G. Vos, and Raymond Pieters

Hexachlorobenzene-induced Immunopathology in Brown Norway Rats is Partly Mediated by T Cells
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 78: 88-95; doi:10.1093/toxsci/kfh034 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Iris A. Camacho, Mitzi Nagarkatti, and Prakash S. Nagarkatti

Evidence for Induction of Apoptosis in T Cells from Murine Fetal Thymus following Perinatal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 96-106; doi:10.1093/toxsci/kfh048 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. R. Germolec, A. Nyska, M. Kashon, C. F. Kuper, C. Portier, C. Kommineni, K. A. Johnson, and M. I. Luster

Extended Histopathology in Immunotoxicity Testing: Interlaboratory Validation Studies
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 107-115; doi:10.1093/toxsci/kfh049 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Michael T. Fisher, Mitzi Nagarkatti, and Prakash S. Nagarkatti

Combined Screening of Thymocytes Using Apoptosis-Specific cDNA Array and Promoter Analysis Yields Novel Gene Targets Mediating TCDD-Induced Toxicity
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 116-124; doi:10.1093/toxsci/kfh058 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICITY:

Anne Caughlan, Kathleen Newhouse, Uk Namgung, and Zhengui Xia

Chlorpyrifos Induces Apoptosis in Rat Cortical Neurons that is Regulated by a Balance Between p38 and ERK/JNK MAP Kinases
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 125-134; doi:10.1093/toxsci/kfh038 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Cynthia J. Wolf, Gerald A. LeBlanc, and L. Earl Gray, Jr.

Interactive Effects of Vinclozolin and Testosterone Propionate on Pregnancy and Sexual Differentiation of the Male and Female SD Rat
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 135-143; doi:10.1093/toxsci/kfh018 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tammy E. Stoker, Susan C. Laws, Kevin M. Crofton, Joan M. Hedge, Janet M. Ferrell, and Ralph L. Cooper

Assessment of DE-71, a Commercial Polybrominated Diphenyl Ether (PBDE) Mixture, in the EDSP Male and Female Pubertal Protocols
Toxicol. Sci. 2004 78: 144-155; doi:10.1093/toxsci/kfh029 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jayaprakash Aravindakshan, Valérie Paquet, Mary Gregory, Julie Dufresne, Michel Fournier, David J. Marcogliese, and Daniel G. Cyr

Consequences of Xenoestrogen Exposure on Male Reproductive Function in Spottail Shiners (Notropis hudsonius)
ToxSci Advance Access published on December 2, 2003
Toxicol. Sci. 2004 78: 156-165; doi:10.1093/toxsci/kfh042 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jiangang Chen, Twanda L. Thirkill, Peter N. Lohstroh, Susan R. Bielmeier, Michael G. Narotsky, Deborah S. Best, Randy A. Harrison, Kala Natarajan, Rex A. Pegram, James W. Overstreet, Bill L. Lasley, and Gordon C. Douglas

Bromodichloromethane Inhibits Human Placental Trophoblast Differentiation
ToxSci Advance Access published on December 22, 2003
Toxicol. Sci. 2004 78: 166-174; doi:10.1093/toxsci/kfh046 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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