Toxicological Sciences

EDITORIALS:

Jerry M. Rice

On the Application of Data on Mode of Action to Carcinogenic Risk Assessment
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 78: 175-177; doi:10.1093/toxsci/kfh102 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Cody L. Wilson

Molecular Switch Circuits in Toxicology: A Dimmer Switch for Dioxin
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 78: 178-180; doi:10.1093/toxsci/kfh087 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Samuel M. Cohen, James Klaunig, M. Elizabeth Meek, Richard N. Hill, Timothy Pastoor, Lois Lehman-McKeeman, John Bucher, David G. Longfellow, Jennifer Seed, Vicki Dellarco, Penelope Fenner-Crisp, and Dorothy Patton

Evaluating the Human Relevance of Chemically Induced Animal Tumors
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 181-186; doi:10.1093/toxsci/kfh073 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Shelley Brown DuTeaux, John W. Newman, Christophe Morisseau, Elise A. Fairbairn, Karen Jelks, Bruce D. Hammock, and Marion G. Miller

Epoxide Hydrolases in the Rat Epididymis: Possible Roles in Xenobiotic and Endogenous Fatty Acid Metabolism
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 187-195; doi:10.1093/toxsci/kfh066 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Bjarte Furnes and Daniel Schlenk

Evaluation of Xenobiotic N- and S-Oxidation by Variant Flavin-Containing Monooxygenase 1 (FMO1) Enzymes
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 78: 196-203; doi:10.1093/toxsci/kfh079 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Neera V. Gopee, Victor J. Johnson, and Raghubir P. Sharma

Sodium Selenite-Induced Apoptosis in Murine B-Lymphoma Cells Is Associated with Inhibition of Protein Kinase C-, Nuclear Factor B, and Inhibitor of Apoptosis Protein
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 204-214; doi:10.1093/toxsci/kfh072 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Kum-Joo Shin, Sun-Hee Kim, Dohan Kim, Yun-Hee Kim, Han-Woong Lee, Yoon-Seok Chang, Man-Bock Gu, Sung Ho Ryu, and Pann-Ghill Suh

2,2',4,6,6'-Pentachlorobiphenyl Induces Mitotic Arrest and p53 Activation
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 215-221; doi:10.1093/toxsci/kfh069 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Yoshiki Kuroda, Jun Akaogi, Dina C. Nacionales, Scott C. Wasdo, Nancy J. Szabo, Westley H. Reeves, and Minoru Satoh

Distinctive Patterns of Autoimmune Response Induced by Different Types of Mineral Oil
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 222-228; doi:10.1093/toxsci/kfh063 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Manuel Ammerschlaeger, Jürgen Beigel, Kai-Uwe Klein, and Stefan O. Mueller

Characterization of the Species-Specificity of Peroxisome Proliferators in Rat and Human Hepatocytes
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 78: 229-240; doi:10.1093/toxsci/kfh071 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Xun Song, Carey Pope, Ramesh Murthy, Jamaluddin Shaikh, Bachchu Lal, and Joseph P. Bressler

Interactive Effects of Paraoxon and Pyridostigmine on Blood-Brain Barrier Integrity and Cholinergic Toxicity
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 78: 241-247; doi:10.1093/toxsci/kfh076 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Beth A. Vorderstrasse, Suzanne E. Fenton, Andrea A. Bohn, Jennifer A. Cundiff, and B. Paige Lawrence

A Novel Effect of Dioxin: Exposure during Pregnancy Severely Impairs Mammary Gland Differentiation
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 248-257; doi:10.1093/toxsci/kfh062 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. M. Bello, W. Heideman, and R. E. Peterson

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Inhibits Regression of the Common Cardinal Vein in Developing Zebrafish
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 78: 258-266; doi:10.1093/toxsci/kfh065 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

J. Flemming, B. Hudson, and T. G. Rand

Comparison of Inflammatory and Cytotoxic Lung Responses in Mice after Intratracheal Exposure to Spores of Two Different Stachybotrys chartarum Strains
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 78: 267-275; doi:10.1093/toxsci/kfh064 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

C. Tenley French, William H. Hanneman, Laura S. Chubb, Ruth E. Billings, and Melvin E. Andersen

Induction of CYP1A1 in Primary Rat Hepatocytes by 3,3',4,4',5-Pentachlorobiphenyl: Evidence for a Switch Circuit Element
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 78: 276-286; doi:10.1093/toxsci/kfh105 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Carolyn J. Broccardo, Ruth E. Billings, Laura S. Chubb, Melvin E. Andersen, and William H. Hanneman

Single Cell Analysis of Switch-Like Induction of CYP1A1 in Liver Cell Lines
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 78: 287-294; doi:10.1093/toxsci/kfh077 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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