Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

J. A. Campain

Nicotine: Potentially a Multifunctional Carcinogen?
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 1-3; doi:10.1093/toxsci/kfh106 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Kristine L. Willett, Robert A. Roth, and Larry Walker

Workshop Overview: Hepatotoxicity Assessment for Botanical Dietary Supplements
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 4-9; doi:10.1093/toxsci/kfh075 [Abstract] [FREE Full Text] [PDF] Supplemental Data [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Xinzhu Pu, Linda S. Lee, Raymond E. Galinsky, and Gary P. Carlson

Evaluation of a Rat Model versus a Physiologically Based Extraction Test for Assessing Phenanthrene Bioavailability from Soils
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 10-17; doi:10.1093/toxsci/kfh091 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew W. Himmelstein, Steven C. Carpenter, and Paul M. Hinderliter

Kinetic Modeling of ß-Chloroprene Metabolism: I. In vitro Rates in Liver and Lung Tissue Fractions from Mice, Rats, Hamsters, and Humans
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 18-27; doi:10.1093/toxsci/kfh092 [Abstract] [FREE Full Text] [PDF] Supplemental Data [Request Permissions]  

Matthew W. Himmelstein, Steven C. Carpenter, Marina V. Evans, Paul M. Hinderliter, and Elaina M. Kenyon

Kinetic Modeling of ß-Chloroprene Metabolism: II. The Application of Physiologically Based Modeling for Cancer Dose Response Analysis
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 28-37; doi:10.1093/toxsci/kfh096 [Abstract] [FREE Full Text] [PDF] Supplemental Data [Request Permissions]  

CARCINOGENESIS:

William J. Waddell, Neil H. Crooks, and Paul L. Carmichael

Correlation of Tumors with DNA Adducts from Methyl Eugenol and Tamoxifen in Rats
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 38-40; doi:10.1093/toxsci/kfh088 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Parvaneh Espandiari, Howard P. Glauert, Hans-Joachim Lehmler, Eun Y. Lee, Cidambi Srinivasan, and Larry W. Robertson

Initiating Activity of 4-Chlorobiphenyl Metabolites in the Resistant Hepatocyte Model
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 41-46; doi:10.1093/toxsci/kfh097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Krishna P. Gupta and Jaya Singh

Modulation of Carcinogen Metabolism and DNA Interaction by Calcium Glucarate in Mouse Skin
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 47-55; doi:10.1093/toxsci/kfh098 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Donald A. Sens, Seongmi Park, Volkan Gurel, Mary Ann Sens, Scott H. Garrett, and Seema Somji

Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human Bladder Urothelial Cells
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 56-63; doi:10.1093/toxsci/kfh086 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tomoya Yamada, Takeshi Kunimatsu, Kaori Miyata, Setsuko Yabushita, Tokuo Sukata, Satoshi Kawamura, Takaki Seki, Yasuyoshi Okuno, and Nobuyoshi Mikami

Enhanced Rat Hershberger Assay Appears Reliable for Detection of Not Only (Anti-)androgenic Chemicals but Also Thyroid Hormone Modulators
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 64-74; doi:10.1093/toxsci/kfh093 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Gabriella Argentin and Rosadele Cicchetti

Genotoxic and Antiapoptotic Effect of Nicotine on Human Gingival Fibroblasts
ToxSci Advance Access published on January 12, 2004
Toxicol. Sci. 2004 79: 75-81; doi:10.1093/toxsci/kfh061 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Diane J. Abernethy, Elena V. Kleymenova, Jason Rose, Leslie Recio, and Brenda Faiola

Human CD34⁺ Hematopoietic Progenitor Cells Are Sensitive Targets for Toxicity Induced by 1,4-Benzoquinone
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 82-89; doi:10.1093/toxsci/kfh095 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Stefan Nierkens, Leonie Nieuwenhuijsen, Mieke Thomas, and Raymond Pieters

Evaluation of the Use of Reporter Antigens in an Auricular Lymph Node Assay to Assess the Immunosensitizing Potential of Drugs
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 90-97; doi:10.1093/toxsci/kfh074 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. M. Brundage, R. Schafer, and J. B. Barnett

Altered AP-1 (Activating Protein-1) Activity and c-jun Activation in T Cells Exposed to the Amide Class Herbicide 3,4-Dichloropropionanilide (DCPA)
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 98-105; doi:10.1093/toxsci/kfh090 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Pratibha V. Nerurkar, Klaus Dragull, and Chung-Shih Tang

In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 79: 106-111; doi:10.1093/toxsci/kfh067 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

V. C. Moser, P. M. Phillips, A. B. Levine, K. L. McDaniel, R. C. Sills, B. S. Jortner, and M. T. Butt

Neurotoxicity Produced by Dibromoacetic Acid in Drinking Water of Rats
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 112-122; doi:10.1093/toxsci/kfh081 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. Reeves, M. Thiruchelvam, and D. A. Cory-Slechta

Development of Behavioral Sensitization to the Cocaine-Like Fungicide Triadimefon Is Prevented by AMPA, NMDa, DA D1 but Not DA D2 RECEPTOR Antagonists
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 79: 123-136; doi:10.1093/toxsci/kfh084 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kathleen Newhouse, Shih-Ling Hsuan, Sandra H. Chang, Beibei Cai, Yupeng Wang, and Zhengui Xia

Rotenone-Induced Apoptosis Is Mediated By p38 And JNK MAP Kinases In Human Dopaminergic SH-SY5Y Cells
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 137-146; doi:10.1093/toxsci/kfh089 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yuansheng Tan, Renji Song, David Lawrence, and David O. Carpenter

Ortho-Substituted but Not Coplanar PCBs Rapidly Kill Cerebellar Granule Cells
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 147-156; doi:10.1093/toxsci/kfh108 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

C. L. Gaworski, E. L. Carmines, A. S. Faqi, and N. Rajendran

In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 157-169; doi:10.1093/toxsci/kfh083 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

C. W. Yap, C. Z. Cai, Y. Xue, and Y. Z. Chen

Prediction of Torsade-Causing Potential of Drugs by Support Vector Machine Approach
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 170-177; doi:10.1093/toxsci/kfh082 [Abstract] [FREE Full Text] [PDF] Supplemental Data [Request Permissions]  

Rebecca E. Watson, James M. McKim, Gary L. Cockerell, and Jay I. Goodman

The Value of DNA Methylation Analysis in Basic, Initial Toxicity Assessments
ToxSci Advance Access published on April 21, 2004
Toxicol. Sci. 2004 79: 178-188; doi:10.1093/toxsci/kfh099 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Marcela A. Gonzalez, Marcelo G. Roma, Claudio A. Bernal, Maria de Lujan Alvarez, and Maráia C. Carrillo

Biliary Secretory Function in Rats Chronically Intoxicated with Aluminum
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 189-195; doi:10.1093/toxsci/kfh085 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anabela P. Rolo, Carlos M. Palmeira, Jon M. Holy, and Kendall B. Wallace

Role of Mitochondrial Dysfunction in Combined Bile Acid–Induced Cytotoxicity: The Switch Between Apoptosis and Necrosis
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 196-204; doi:10.1093/toxsci/kfh078 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Henk P. M. Vijverberg and Martin van den Berg

LETTER TO THE EDITOR
Toxicol. Sci. 2004 79: 205-206; doi:10.1093/toxsci/kfh059 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Per Eriksson and Henrik Viberg

LETTER TO THE EDITOR
Toxicol. Sci. 2004 79: 207-208; doi:10.1093/toxsci/kfh107 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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