Toxicological Sciences

EDITORIALS:

Richard J. Kociba

PROFILES IN TOXICOLOGY: V. K. Rowe (1914–2004)
Toxicol. Sci. 2004 79: 209-210; doi:10.1093/toxsci/kfh141 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

David H. Sherr

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Long Term Immunologic Memory
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 79: 211-213; doi:10.1093/toxsci/kfh136 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Julio C. Davila, Gabriela G. Cezar, Mark Thiede, Stephen Strom, Toshio Miki, and James Trosko

Use and Application of Stem Cells in Toxicology
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 79: 214-223; doi:10.1093/toxsci/kfh100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Erika L. Abel, Theo K. Bammler, and David L. Eaton

Biotransformation of Methyl Parathion by Glutathione S-Transferases
ToxSci Advance Access published on April 21, 2004
Toxicol. Sci. 2004 79: 224-232; doi:10.1093/toxsci/kfh118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Judy L. Raucy, Jerome Lasker, Kazuaki Ozaki, and Veronica Zoleta

Regulation of CYP2E1 by Ethanol and Palmitic Acid and CYP4A11 by Clofibrate in Primary Cultures of Human Hepatocytes
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 233-241; doi:10.1093/toxsci/kfh126 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

W. T. Stott, B. J. Radtke, V. A. Linscombe, M.-H. Mar, and S. H. Zeisel

Evaluation of the Potential of Triethanolamine to Alter Hepatic Choline Levels in Female B6C3F1 Mice
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 242-247; doi:10.1093/toxsci/kfh115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

K. J. Trouba and D. R. Germolec

Micromolar Concentrations of Sodium Arsenite Induce Cyclooxygenase-2 Expression and Stimulate p42/44 Mitogen-Activated Protein Kinase Phosphorylation in Normal Human Epidermal Keratinocytes
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 248-257; doi:10.1093/toxsci/kfh132 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Belinda S. Hawkins and Lawrence J. Fischer

Inhibition of Insulin Synthesis by Cyproheptadine: Effects on Translation
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 258-265; doi:10.1093/toxsci/kfh113 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. E. Malstrom, O. Tornavaca, A. Meseguer, A. F. Purchio, and D. B. West

The Characterization and Hormonal Regulation of Kidney Androgen-Regulated Protein (Kap)-Luciferase Transgenic Mice
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 266-277; doi:10.1093/toxsci/kfh125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tami S. McMullin, Melvin E. Andersen, Alan Nagahara, Trent D. Lund, Toni Pak, Robert J. Handa, and William H. Hanneman

Evidence That Atrazine and Diaminochlorotriazine Inhibit the Estrogen/Progesterone Induced Surge of Luteinizing Hormone in Female Sprague-Dawley Rats Without Changing Estrogen Receptor Action
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 278-286; doi:10.1093/toxsci/kfh127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Ronald C. Wester, Xiaoying Hui, Sherry Barbadillo, Howard I. Maibach, Yvette W. Lowney, Rosalind A. Schoof, Stewart E. Holm, and Michael V. Ruby

In Vivo Percutaneous Absorption of Arsenic from Water and CCA-Treated Wood Residue
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 287-295; doi:10.1093/toxsci/kfh114 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Claudia Ramos Rhoden, Joy Lawrence, John J. Godleski, and Beatriz González-Flecha

N-Acetylcysteine Prevents Lung Inflammation After Short-Term Inhalation Exposure to Concentrated Ambient Particles
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 296-303; doi:10.1093/toxsci/kfh122 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

B. Paige Lawrence and Beth A. Vorderstrasse

Activation of the Aryl Hydrocarbon Receptor Diminishes the Memory Response to Homotypic Influenza Virus Infection but Does Not Impair Host Resistance
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 304-314; doi:10.1093/toxsci/kfh094 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Aimen K. Farraj, Jack R. Harkema, and Norbert E. Kaminski

Allergic Rhinitis Induced by Intranasal Sensitization and Challenge with Trimellitic Anhydride but Not with Dinitrochlorobenzene or Oxazolone in A/J Mice
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 315-325; doi:10.1093/toxsci/kfh112 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chen-Chen Lee, Jiunn-Wang Liao, and Jaw-Jou Kang

Motorcycle Exhaust Particles Induce Airway Inflammation and Airway Hyperresponsiveness in BALB/C Mice
ToxSci Advance Access published on January 21, 2004
Toxicol. Sci. 2004 79: 326-334; doi:10.1093/toxsci/kfh070 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hind Assaf, Hayat Azouri, and Marc Pallardy

Ochratoxin A Induces Apoptosis in Human Lymphocytes through Down Regulation of Bcl-x_L
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 335-344; doi:10.1093/toxsci/kfh123 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Svetlana Mikheeva, Marianne Barrier, Sally A. Little, Richard Beyer, Andrei M. Mikheev, M. Kathleen Kerr, and Philip E. Mirkes

Alterations in Gene Expression Induced in Day-9 Mouse Embryos Exposed to Hyperthermia (HS) or 4-Hydroperoxycyclophosphamide (4CP): Analysis Using cDNA Microarrays
ToxSci Advance Access published on February 19, 2004
Toxicol. Sci. 2004 79: 345-359; doi:10.1093/toxsci/kfh080 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kinarm Ko, H. Michael Theobald, Robert W. Moore, and Richard E. Peterson

Evidence that Inhibited Prostatic Epithelial Bud Formation in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Exposed C57BL/6J Fetal Mice Is Not Due to Interruption of Androgen Signaling in the Urogenital Sinus
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 360-369; doi:10.1093/toxsci/kfh111 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Dale W. Porter, Ann F. Hubbs, Robert Mercer, Victor A. Robinson, Dawn Ramsey, Jeff McLaurin, Amir Khan, Lori Battelli, Kurt Brumbaugh, Alexander Teass, and Vincent Castranova

Progression of Lung Inflammation and Damage in Rats After Cessation of Silica Inhalation
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 370-380; doi:10.1093/toxsci/kfh110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Harvey J. Clewell, P. Robinan Gentry, Tammie R. Covington, Ramesh Sarangapani, and Justin G. Teeguarden

Evaluation of the Potential Impact of Age- and Gender-Specific Pharmacokinetic Differences on Tissue Dosimetry
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 381-393; doi:10.1093/toxsci/kfh109 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Lisa M. Sweeney, Melvin E. Andersen, and Michael L. Gargas

Ethyl Acrylate Risk Assessment with a Hybrid Computational Fluid Dynamics and Physiologically Based Nasal Dosimetry Model
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 394-403; doi:10.1093/toxsci/kfh116 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Youchun Jiang, Jie Liu, Michael Waalkes, and Y. James Kang

Changes in the Gene Expression Associated with Carbon Tetrachloride-Induced Liver Fibrosis Persist after Cessation of Dosing in Mice
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 404-410; doi:10.1093/toxsci/kfh120 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wilbert H. M. Heijne, Angela L. Slitt, Peter J. van Bladeren, John P. Groten, Curtis D. Klaassen, Rob H. Stierum, and Ben van Ommen

Bromobenzene-Induced Hepatotoxicity at the Transcriptome Level
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 79: 411-422; doi:10.1093/toxsci/kfh128 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

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