Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Robert E. Chapin

Nature Is Complex: Our Orchestra Seats at the Most Wonderful Show on Earth
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 1-2; doi:10.1093/toxsci/kfh171 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Christopher L. Sprague, Lynette A. Phillips, Karen M. Young, and Adnan A. Elfarra

Species and Tissue Differences in the Toxicity of 3-Butene-1,2-diol in Male Sprague-Dawley Rats and B6C3F1 Mice
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 3-13; doi:10.1093/toxsci/kfh156 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Stefan O. Mueller, Stephanie Simon, Kun Chae, Manfred Metzler, and Kenneth S. Korach

Phytoestrogens and Their Human Metabolites Show Distinct Agonistic and Antagonistic Properties on Estrogen Receptor (ER) and ERß in Human Cells
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 14-25; doi:10.1093/toxsci/kfh147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

K. L. Henson and E. P. Gallagher

Glutathione S-Transferase Expression in Pollution-Associated Hepatic Lesions of Brown Bullheads (Ameiurus nebulosus) from the Cuyahoga River, Cleveland, Ohio
ToxSci Advance Access published on April 7, 2004
Toxicol. Sci. 2004 80: 26-33; doi:10.1093/toxsci/kfh133 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Michael S. Thibodeau, Charles Giardina, David A. Knecht, Joseph Helble, and Andrea K. Hubbard

Silica-Induced Apoptosis in Mouse Alveolar Macrophages Is Initiated by Lysosomal Enzyme Activity
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 80: 34-48; doi:10.1093/toxsci/kfh121 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

IN VITRO TOXICOLOGY:

Xi Sun, Fang Li, You-jie Wang, Yi-rong Li, Yan-hua Su, Yuan-yuan Li, Hong Yan, and Shun-qing Xu

Development of an Exonuclease Protection Mediated PCR Bioassay for Sensitive Detection of Ah Receptor Agonists
ToxSci Advance Access published on April 7, 2004
Toxicol. Sci. 2004 80: 49-53; doi:10.1093/toxsci/kfh137 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

NEUROTOXICOLOGY:

Yuansheng Tan, Chang-Hwei Chen, David Lawrence, and David O. Carpenter

Ortho-Substituted PCBs Kill Cells by Altering Membrane Structure
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 80: 54-59; doi:10.1093/toxsci/kfh119 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tobi L. Limke, Jeremy J. Bearss, and William D. Atchison

Acute Exposure to Methylmercury Causes Ca²⁺ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 60-68; doi:10.1093/toxsci/kfh131 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Minoru Yoshida, Chiho Watanabe, Masahiko Satoh, Akira Yasutake, Masumi Sawada, Yuko Ohtsuka, Yoshifumi Akama, and Chiharu Tohyama

Susceptibility of Metallothionein-Null Mice to the Behavioral Alterations Caused by Exposure to Mercury Vapor at Human-Relevant Concentration
ToxSci Advance Access published on April 7, 2004
Toxicol. Sci. 2004 80: 69-73; doi:10.1093/toxsci/kfh138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anabel Pérez-Gómez, Armando García-Rodríguez, Kevin J. James, Amaia Ferrero-Gutierrez, Antonello Novelli, and M. Teresa Fernández-Sánchez

The Marine Toxin Dinophysistoxin-2 Induces Differential Apoptotic Death of Rat Cerebellar Neurons and Astrocytes
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 74-82; doi:10.1093/toxsci/kfh139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

K. J. Bodensteiner, H. R. Sawyer, C. L. Moeller, C. M. Kane, K.-Y. F. Pau, G. R. Klinefelter, and D. N. R. Veeramachaneni

Chronic Exposure to Dibromoacetic Acid, a Water Disinfection Byproduct, Diminishes Primordial Follicle Populations in the Rabbit
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 83-91; doi:10.1093/toxsci/kfh135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

HIGHLIGHTED ARTICLE:

Robert J. Markelewicz, Jr., Susan J. Hall, and Kim Boekelheide

2,5-Hexanedione and Carbendazim Coexposure Synergistically Disrupts Rat Spermatogenesis Despite Opposing Molecular Effects on Microtubules
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 92-100; doi:10.1093/toxsci/kfh140 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ulla Simanainen, Tapio Haavisto, Jouni T. Tuomisto, Jorma Paranko, Jorma Toppari, Jouko Tuomisto, Richard E. Peterson, and Matti Viluksela

Pattern of Male Reproductive System Effects After in Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Exposure in Three Differentially TCDD-Sensitive Rat Lines
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 101-108; doi:10.1093/toxsci/kfh142 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

RISK ASSESSMENT:

S. Fukushima, H. Wanibuchi, K. Morimura, S. Iwai, D. Nakae, H. Kishida, H. Tsuda, N. Uehara, K. Imaida, T. Shirai, M. Tatematsu, T. Tsukamoto, M. Hirose, and F. Furukawa

Existence of a Threshold for Induction of Aberrant Crypt Foci in the Rat Colon with Low Doses of 2-Amino-1-methyl-6-phenolimidazo[4,5-b]pyridine
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 80: 109-114; doi:10.1093/toxsci/kfh104 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Claude Emond, Linda S. Birnbaum, and Michael J. DeVito

Physiologically Based Pharmacokinetic Model for Developmental Exposures to TCDD in the Rat
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 80: 115-133; doi:10.1093/toxsci/kfh117 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chris Gennings, W. Hans Carter, Jr., Edward W. Carney, Grantley D. Charles, B. Bhaskar Gollapudi, and Richard A. Carchman

A Novel Flexible Approach for Evaluating Fixed Ratio Mixtures of Full and Partial Agonists
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 134-150; doi:10.1093/toxsci/kfh134 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jonathan M. Shipley, Christopher H. Hurst, Sue S. Tanaka, Fred L. DeRoos, John L. Butenhoff, Andrew M. Seacat, and David J. Waxman

trans-Activation of PPAR and Induction of PPAR Target Genes by Perfluorooctane-Based Chemicals
ToxSci Advance Access published on April 7, 2004
Toxicol. Sci. 2004 80: 151-160; doi:10.1093/toxsci/kfh130 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jun Adachi, Yoshitomo Mori, Saburo Matsui, and Tomonari Matsuda

Comparison of Gene Expression Patterns between 2,3,7,8-Tetrachlorodibenzo-p-dioxin and a Natural Arylhydrocarbon Receptor Ligand, Indirubin
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 80: 161-169; doi:10.1093/toxsci/kfh129 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jing Jiang, Dana Dean, Robert C. Burghardt, and Alan R. Parrish

Disruption of Cadherin/Catenin Expression, Localization, and Interactions During HgCl₂-Induced Nephrotoxicity
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 170-182; doi:10.1093/toxsci/kfh143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

H. M. Colton, J. G. Falls, H. Ni, P. Kwanyuen, D. Creech, E. McNeil, W. M. Casey, G. Hamilton, and N. F. Cariello

Visualization and Quantitation of Peroxisomes Using Fluorescent Nanocrystals: Treatment of Rats and Monkeys with Fibrates and Detection in the Liver
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 183-192; doi:10.1093/toxsci/kfh144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alexandra N. Heinloth, Richard D. Irwin, Gary A. Boorman, Paul Nettesheim, Rickie D. Fannin, Stella O. Sieber, Michael L. Snell, Charles J. Tucker, Leping Li, Gregory S. Travlos, Gordon Vansant, Pamela E. Blackshear, Raymond W. Tennant, Michael L. Cunningham, and Richard S. Paules

Gene Expression Profiling of Rat Livers Reveals Indicators of Potential Adverse Effects
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 193-202; doi:10.1093/toxsci/kfh145 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

James P. Luyendyk, William B. Mattes, Lyle D. Burgoon, Timothy R. Zacharewski, Jane F. Maddox, Gregory N. Cosma, Patricia E. Ganey, and Robert A. Roth

Gene Expression Analysis Points to Hemostasis in Livers of Rats Cotreated with Lipopolysaccharide and Ranitidine
ToxSci Advance Access published on April 14, 2004
Toxicol. Sci. 2004 80: 203-213; doi:10.1093/toxsci/kfh146 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

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