Toxicological Sciences

EDITORIALS:

Jay I. Goodman and Lois D. Lehman-McKeeman

Introducing a Forum Series: Approaches for Assessing the Human Carcinogenic Risk of Chemicals
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 80: 215; doi:10.1093/toxsci/kfh188 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Mark J. Melancon

Nonlethal Development, Validation, and Application of Cytochrome P4501A1 (CYP1A1) as a Biomarker for Contaminant Exposure
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 80: 216-217; doi:10.1093/toxsci/kfh181 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Jonathan G. Moggs and George Orphanides

The Role of Chromatin in Molecular Mechanisms of Toxicity
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 218-224; doi:10.1093/toxsci/kfh164 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Samuel M. Cohen

Human Carcinogenic Risk Evaluation: An Alternative Approach to the Two-Year Rodent Bioassay
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 225-229; doi:10.1093/toxsci/kfh159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Erika L. Abel, Shaun M. Opp, Christophe L. M. J. Verlinde, Theo K. Bammler, and David L. Eaton

Characterization of Atrazine Biotransformation by Human and Murine Glutathione S-Transferases
ToxSci Advance Access published on April 28, 2004
Toxicol. Sci. 2004 80: 230-238; doi:10.1093/toxsci/kfh152 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. A. Kousba, L. G. Sultatos, T. S. Poet, and C. Timchalk

Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics: Potential Role of a Peripheral Binding Site
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 239-248; doi:10.1093/toxsci/kfh163 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey D. Vassallo, Sarah M. Hicks, George P. Daston, and Lois D. Lehman-McKeeman

Metabolic Detoxification Determines Species Differences in Coumarin-Induced Hepatotoxicity
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 249-257; doi:10.1093/toxsci/kfh162 [Abstract] [FREE Full Text] [PDF] Supplementary DataSupplementary Data [Request Permissions]  

CARCINOGENESIS:

Marjo V. Smith, Abraham Nyska, and Chris Portier

Application of a Statistical Dynamic Model Investigating the Short-Term Cellular Kinetics Induced by Riddelliine, a Hepatic Endothelial Carcinogen
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 258-267; doi:10.1093/toxsci/kfh157 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Céline A. J. Godard, Roxanna M. Smolowitz, Joanna Y. Wilson, Roger S. Payne, and John J. Stegeman

Induction of Cetacean Cytochrome P4501A1 by ß-Naphthoflavone Exposure of Skin Biopsy Slices
ToxSci Advance Access published on March 31, 2004
Toxicol. Sci. 2004 80: 268-275; doi:10.1093/toxsci/kfh124 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Karen Van Campenhout, Heidi Goenaga Infante, Freddy Adams, and Ronny Blust

Induction and Binding of Cd, Cu, and Zn to Metallothionein in Carp (Cyprinus carpio) Using HPLC-ICP-TOFMS
ToxSci Advance Access published on April 21, 2004
Toxicol. Sci. 2004 80: 276-287; doi:10.1093/toxsci/kfh149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Jeffrey C. Bemis and Richard F. Seegal

PCB-Induced Inhibition of the Vesicular Monoamine Transporter Predicts Reductions in Synaptosomal Dopamine Content
ToxSci Advance Access published on April 28, 2004
Toxicol. Sci. 2004 80: 288-295; doi:10.1093/toxsci/kfh153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Oddvar Myhre, Sigrun Hanne Sterri, Inger Lise Bogen, and Frode Fonnum

Erk1/2 Phosphorylation and Reactive Oxygen Species Formation via Nitric Oxide and Akt-1/Raf-1 Crosstalk in Cultured Rat Cerebellar Granule Cells Exposed to the Organic Solvent 1,2,4-Trimethylcyclohexane
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 296-303; doi:10.1093/toxsci/kfh166 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Guy Huel, Chadi Yazbeck, Daniel Burnel, Pascale Missy, and Wolfram Kloppmann

Environmental Boron Exposure and Activity of -Aminolevulinic Acid Dehydratase (ALA-D) in a Newborn Population
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 304-309; doi:10.1093/toxsci/kfh165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Jeroen A. J. Vanoirbeek, Maciej Tarkowski, Jan L. Ceuppens, Erik K. Verbeken, Benoit Nemery, and Peter H. M. Hoet

Respiratory Response to Toluene Diisocyanate Depends on Prior Frequency and Concentration of Dermal Sensitization in Mice
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 310-321; doi:10.1093/toxsci/kfh155 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Tony L. Yaksh, Kjersti A. Horais, Nicolle Tozier, Michael Rathbun, Phil Richter, Steve Rossi, Marjorie Grafe, Chuanyao Tong, Carol Meschter, J. Mark Cline, and James Eisenach

Intrathecal Ketorolac in Dogs and Rats
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 322-334; doi:10.1093/toxsci/kfh168 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Quanren He, Jiyoung Kim, and Raghubir P. Sharma

Silymarin Protects Against Liver Damage in BALB/c Mice Exposed to Fumonisin B₁ Despite Increasing Accumulation of Free Sphingoid Bases
ToxSci Advance Access published on April 21, 2004
Toxicol. Sci. 2004 80: 335-342; doi:10.1093/toxsci/kfh148 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mary Lynn Bajt, Tamara R. Knight, John J. Lemasters, and Hartmut Jaeschke

Acetaminophen-Induced Oxidant Stress and Cell Injury in Cultured Mouse Hepatocytes: Protection by N-Acetyl Cysteine
ToxSci Advance Access published on April 28, 2004
Toxicol. Sci. 2004 80: 343-349; doi:10.1093/toxsci/kfh151 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jing Dong, Jeffrey I. Everitt, Serrine S. Lau, and Terrence J. Monks

Induction of ERK1/2 and Histone H3 Phosphorylation within the Outer Stripe of the Outer Medulla of the Eker Rat by 2,3,5-Tris-(Glutathion-S-yl)hydroquinone
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 350-357; doi:10.1093/toxsci/kfh160 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Seema Somji, Scott H. Garrett, Mary Ann Sens, Volkan Gurel, and Donald A. Sens

Expression of Metallothionein Isoform 3 (MT-3) Determines the Choice between Apoptotic or Necrotic Cell Death in Cd⁺²-Exposed Human Proximal Tubule Cells
ToxSci Advance Access published on May 5, 2004
Toxicol. Sci. 2004 80: 358-366; doi:10.1093/toxsci/kfh158 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gregory A. Wellenius, Joao R. F. Batalha, Edgar A. Diaz, Joy Lawrence, Brent A. Coull, Tracy Katz, Richard L. Verrier, and John J. Godleski

Cardiac Effects of Carbon Monoxide and Ambient Particles in a Rat Model of Myocardial Infarction
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 80: 367-376; doi:10.1093/toxsci/kfh161 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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