Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Diane S. Henshel

Control of Glutathione Synthesis in Early Embryo Development
Toxicol. Sci. 2004 81: 257-259; doi:10.1093/toxsci/kfh227 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Abigail Jacobs and David Jacobson-Kram

Human Carcinogenic Risk Evaluation, Part III: Assessing Cancer Hazard and Risk in Human Drug Development
ToxSci Advance Access published on May 12, 2004
Toxicol. Sci. 2004 81: 260-262; doi:10.1093/toxsci/kfh167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Eva Tydén, Hans Tjälve, and Pia Larsson

Metabolic Activation of 2,6-Xylidine in the Nasal Olfactory Mucosa and the Mucosa of the Upper Alimentary and Respiratory Tracts in Rats
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 263-272; doi:10.1093/toxsci/kfh219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Manabu Hoshi, Keiichirou Morimura, Hideki Wanibuchi, Min Wei, Eriko Okochi, Toshikazu Ushijima, Kunio Takaoka, and Shoji Fukushima

No-Observed Effect Levels for Carcinogenicity and for in vivo Mutagenicity of a Genotoxic Carcinogen
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 81: 273-279; doi:10.1093/toxsci/kfh241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joe L. Mauderly, Andrew P. Gigliotti, Edward B. Barr, William E. Bechtold, Steven A. Belinsky, Fletcher F. Hahn, Charles A. Hobbs, Thomas H. March, Steven K. Seilkop, and Gregory L. Finch

Chronic Inhalation Exposure to Mainstream Cigarette Smoke Increases Lung and Nasal Tumor Incidence in Rats
ToxSci Advance Access published on June 22, 2004
Toxicol. Sci. 2004 81: 280-292; doi:10.1093/toxsci/kfh203 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Keith R. Martin, Micheal P. Jokinen, Hayden P. Honeycutt, Anita Quinn, Frank W. Kari, J. Carl Barrett, and John E. French

Tumor Profile of Novel p53 Heterozygous Tg.AC (v-Ha-ras) Bitransgenic Mice Treated with Benzo(a)pyrene and Fed Dietary N-acetyl-L-cysteine (NAC)
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 293-301; doi:10.1093/toxsci/kfh226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Tsutomu Fukuwatari, Seiko Ohsaki, Shin-ichi Fukuoka, Ryuzo Sasaki, and Katsumi Shibata

Phthalate Esters Enhance Quinolinate Production by Inhibiting -Amino-ß-Carboxymuconate--Semialdehyde Decarboxylase (ACMSD), a Key Enzyme of the Tryptophan Pathway
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 81: 302-308; doi:10.1093/toxsci/kfh204 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yoshihisa Kato, Shinichi Ikushiro, Koichi Haraguchi, Tomoaki Yamazaki, Yuriko Ito, Hiroshi Suzuki, Ryohei Kimura, Shizuo Yamada, Tohru Inoue, and Masakuni Degawa

A Possible Mechanism for Decrease in Serum Thyroxine Level by Polychlorinated Biphenyls in Wistar and Gunn Rats
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 309-315; doi:10.1093/toxsci/kfh225 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Majorie B. M. van Duursen, J. Thomas Sanderson, Paul Chr. de Jong, Marlies Kraaij, and Martin van den Berg

Phytochemicals Inhibit Catechol-O-Methyltransferase Activity in Cytosolic Fractions from Healthy Human Mammary Tissues: Implications for Catechol Estrogen-Induced DNA Damage
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 316-324; doi:10.1093/toxsci/kfh216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

John Weaver, Supatra Porasuphatana, Pei Tsai, Guan-Liang Cao, Theodore A. Budzichowski, Linda J. Roman, and Gerald M. Rosen

The Effect of Divalent Cations on Neuronal Nitric Oxide Synthase Activity
ToxSci Advance Access published on July 7, 2004
Toxicol. Sci. 2004 81: 325-331; doi:10.1093/toxsci/kfh211 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

G. Frank Gerberick, Jeff D. Vassallo, Ruth E. Bailey, Joel G. Chaney, Steve W. Morrall, and Jean-Pierre Lepoittevin

Development of a Peptide Reactivity Assay for Screening Contact Allergens
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 332-343; doi:10.1093/toxsci/kfh213 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Henrik Viberg, Anders Fredriksson, and Per Eriksson

Investigations of Strain and/or Gender Differences in Developmental Neurotoxic Effects of Polybrominated Diphenyl Ethers in Mice
ToxSci Advance Access published on July 7, 2004
Toxicol. Sci. 2004 81: 344-353; doi:10.1093/toxsci/kfh215 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nicholas J. Heyer, Diana Echeverria, Alvah C. Bittner, Jr., Federico M. Farin, Claire C. Garabedian, and James S. Woods

Chronic Low-Level Mercury Exposure, BDNF Polymorphism, and Associations with Self-Reported Symptoms and Mood
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 354-363; doi:10.1093/toxsci/kfh220 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. C. Scallet, L. C. Schmued, W. Slikker, Jr., N. Grunberg, P. J. Faustino, H. Davis, D. Lester, P. S. Pine, F. Sistare, and J. P. Hanig

Developmental Neurotoxicity of Ketamine: Morphometric Confirmation, Exposure Parameters, and Multiple Fluorescent Labeling of Apoptotic Neurons
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 364-370; doi:10.1093/toxsci/kfh224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Jason M. Hansen, Eunyong Lee, and Craig Harris

Spatial Activities and Induction of Glutamate-Cysteine Ligase (GCL) in the Postimplantation Rat Embryo and Visceral Yolk Sac
ToxSci Advance Access published on April 28, 2004
Toxicol. Sci. 2004 81: 371-378; doi:10.1093/toxsci/kfh154 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steve K. Teo, Kevin H. Denny, David I. Stirling, Steve D. Thomas, Sandy Morseth, and Alan M. Hoberman

Effects of Thalidomide on Developmental, Peri- and Postnatal Function in Female New Zealand White Rabbits and Offspring
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 81: 379-389; doi:10.1093/toxsci/kfh207 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa A. Haendel, Fred Tilton, George S. Bailey, and Robert L. Tanguay

Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish
ToxSci Advance Access published on June 16, 2004
Toxicol. Sci. 2004 81: 390-400; doi:10.1093/toxsci/kfh202 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ulla Simanainen, Annika Adamsson, Jouni T. Tuomisto, Hanna M. Miettinen, Jorma Toppari, Jouko Tuomisto, and Matti Viluksela

Adult 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure and Effects on Male Reproductive Organs in Three Differentially TCDD-Susceptible Rat Lines
ToxSci Advance Access published on July 7, 2004
Toxicol. Sci. 2004 81: 401-407; doi:10.1093/toxsci/kfh212 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Arlen Soghomonians, Twanda L. Thirkill, Natalie F. Mariano, Abdul I. Barakat, and Gordon C. Douglas

Effect of Aqueous Tobacco Smoke Extract and Shear Stress on PECAM-1 Expression and Cell Motility in Human Uterine Endothelial Cells
ToxSci Advance Access published on July 7, 2004
Toxicol. Sci. 2004 81: 408-418; doi:10.1093/toxsci/kfh210 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gary R. Klinefelter, Lillian F. Strader, Juan D. Suarez, Naomi L. Roberts, Jerome M. Goldman, and Ashley S. Murr

Continuous Exposure to Dibromoacetic Acid Delays Pubertal Development and Compromises Sperm Quality in the Rat
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 419-429; doi:10.1093/toxsci/kfh217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Emilie H. Kaydos, Juan D. Suarez, Naomi L. Roberts, Kathy Bobseine, Robert Zucker, John Laskey, and Gary R. Klinefelter

Haloacid Induced Alterations in Fertility and the Sperm Biomarker SP22 in the Rat Are Additive: Validation of an ELISA
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 430-442; doi:10.1093/toxsci/kfh218 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Douglas J. Fort, John H. Thomas, Robert L. Rogers, Andra Noll, Clinton D. Spaulding, Patrick D. Guiney, and John A. Weeks

Evaluation of the Developmental and Reproductive Toxicity of Methoxychlor using an Anuran (Xenopus tropicalis) Chronic Exposure Model
ToxSci Advance Access published on July 22, 2004
Toxicol. Sci. 2004 81: 443-453; doi:10.1093/toxsci/kfh230 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Douglas J. Fort, Patrick D. Guiney, John A. Weeks, John H. Thomas, Robert L. Rogers, Andra M. Noll, and Clinton D. Spaulding

Effect of Methoxychlor on Various Life Stages of Xenopus laevis
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 81: 454-466; doi:10.1093/toxsci/kfh243 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Fei Gao, Aaron Barchowsky, Antonia A. Nemec, and James P. Fabisiak

Microbial Stimulation by Mycoplasma fermentans Synergistically Amplifies IL-6 Release by Human Lung Fibroblasts in Response to Residual Oil Fly Ash (ROFA) and Nickel
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 81: 467-479; doi:10.1093/toxsci/kfh205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Johan Øvrevik, Marit Låg, Per Schwarze, and Magne Refsnes

p38 and Src-ERK1/2 Pathways Regulate Crystalline Silica-Induced Chemokine Release in Pulmonary Epithelial Cells
ToxSci Advance Access published on July 7, 2004
Toxicol. Sci. 2004 81: 480-490; doi:10.1093/toxsci/kfh214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Salomon Sand, Dietrich von Rosen, Per Eriksson, Anders Fredriksson, Henrik Viberg, Katarina Victorin, and Agneta Falk Filipsson

Dose-Response Modeling and Benchmark Calculations from Spontaneous Behavior Data on Mice Neonatally Exposed to 2,2',4,4',5-Pentabromodiphenyl Ether
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 491-501; doi:10.1093/toxsci/kfh222 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

George Cruzan, Richard A. Corley, Gordon C. Hard, Jos J. W. M. Mertens, Kenneth E. McMartin, William M. Snellings, Ralph Gingell, and James A. Deyo

Subchronic Toxicity of Ethylene Glycol in Wistar and F-344 Rats Related to Metabolism and Clearance of Metabolites
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 81: 502-511; doi:10.1093/toxsci/kfh206 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jack B. Bishop, Yoshiro Tani, Kristine Witt, Jo Anne Johnson, Shyamal Peddada, June Dunnick, and Abraham Nyska

Mitochondrial Damage Revealed by Morphometric and Semiquantitative Analysis of Mouse Pup Cardiomyocytes Following in Utero and Postnatal Exposure to Zidovudine and Lamivudine
ToxSci Advance Access published on June 30, 2004
Toxicol. Sci. 2004 81: 512-517; doi:10.1093/toxsci/kfh208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jiyoung Kim and Raghubir P. Sharma

Calcium-Mediated Activation of c-Jun NH₂-Terminal Kinase (JNK) and Apoptosis in Response to Cadmium in Murine Macrophages
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 81: 518-527; doi:10.1093/toxsci/kfh221 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR:

Marcia L. Hardy

LETTER TO THE EDITOR
Toxicol. Sci. 2004 81: 528-529; doi:10.1093/toxsci/kfh209 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Stefan O. Mueller, Stephanie Simon, Kun Chae, Manfred Metzler, and Kenneth S. Korach

Phytoestrogens and Their Human Metabolites Show Distinct Agonistic and Antagonistic Properties on Estrogen Receptor (ER)and ERß in Human Cells
Toxicol. Sci. 2004 81: 530-531; doi:10.1093/toxsci/kfh259 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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