Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

M. E. Meek

Biologically Motivated Computational Modeling: Contribution to Risk Assessment
ToxSci Advance Access published on September 22, 2004
Toxicol. Sci. 2004 82: 1-2; doi:10.1093/toxsci/kfh282 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

James S. MacDonald

Human Carcinogenic Risk Evaluation, Part IV: Assessment of Human Risk of Cancer from Chemical Exposure Using a Global Weight-of-Evidence Approach
ToxSci Advance Access published on June 8, 2004
Toxicol. Sci. 2004 82: 3-8; doi:10.1093/toxsci/kfh189 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Torka S. Poet, Hong Wu, J. Caroline English, and Richard A. Corley

Metabolic Rate Constants for Hydroquinone in F344 Rat and Human Liver Isolated Hepatocytes: Application to a PBPK Model
ToxSci Advance Access published on July 22, 2004
Toxicol. Sci. 2004 82: 9-25; doi:10.1093/toxsci/kfh229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey D. Vassallo, Sarah M. Hicks, Stephanie L. Born, and George P. Daston

Roles for Epoxidation and Detoxification of Coumarin in Determining Species Differences in Clara Cell Toxicity
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 26-33; doi:10.1093/toxsci/kfh237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Michael E. Wyde, Angelique P. J. M. Braen, Milton Hejtmancik, Jerry D. Johnson, John D. Toft, James C. Blake, Stephen D. Cooper, Joel Mahler, Molly Vallant, John R. Bucher, and Nigel J. Walker

Oral and Dermal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Cutaneous Papillomas and Squamous Cell Carcinomas in Female Hemizygous Tg.AC Transgenic Mice
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 34-45; doi:10.1093/toxsci/kfh233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michele Campaigne Larsen, Paul B. Brake, Richard S. Pollenz, and Colin R. Jefcoate

Linked Expression of Ah Receptor, ARNT, CYP1A1, and CYP1B1 in Rat Mammary Epithelia, in Vitro, Is Each Substantially Elevated by Specific Extracellular Matrix Interactions that Precede Branching Morphogenesis
ToxSci Advance Access published on August 5, 2004
Toxicol. Sci. 2004 82: 46-61; doi:10.1093/toxsci/kfh242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lianhui Tao, Wei Wang, Long Li, Paula M. Kramer, and Michael A. Pereira

Effect of Dibromoacetic Acid on DNA Methylation, Glycogen Accumulation, and Peroxisome Proliferation in Mouse and Rat Liver
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 62-69; doi:10.1093/toxsci/kfh266 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

J. Thomas Sanderson, Joost Hordijk, Michael S. Denison, Mark F. Springsteel, Michael H. Nantz, and Martin van den Berg

Induction and Inhibition of Aromatase (CYP19) Activity by Natural and Synthetic Flavonoid Compounds in H295R Human Adrenocortical Carcinoma Cells
ToxSci Advance Access published on August 19, 2004
Toxicol. Sci. 2004 82: 70-79; doi:10.1093/toxsci/kfh257 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Zongqing Tan, Mingya Huang, Alvaro Puga, and Ying Xia

A Critical Role For MAP Kinases in the Control of Ah Receptor Complex Activity
ToxSci Advance Access published on July 22, 2004
Toxicol. Sci. 2004 82: 80-87; doi:10.1093/toxsci/kfh228 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

John M. Veranth, Christopher A. Reilly, Martha M. Veranth, Tyler A. Moss, Charles R. Langelier, Diane L. Lanza, and Garold S. Yost

Inflammatory Cytokines and Cell Death in BEAS-2B Lung Cells Treated with Soil Dust, Lipopolysaccharide, and Surface-Modified Particles
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 88-96; doi:10.1093/toxsci/kfh248 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Birgit Hoeger, Bernd Koellner, Guenter Kotterba, Michael R. van den Heuvel, Bettina Hitzfeld, and Daniel R. Dietrich

Influence of Chronic Exposure to Treated Sewage Effluent on the Distribution of White Blood Cell Populations in Rainbow Trout (Oncorhynchus mykiss) Spleen
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 97-105; doi:10.1093/toxsci/kfh250 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. M. Anne McNabb, Darryl A. Jang, and Calvert T. Larsen

Does Thyroid Function in Developing Birds Adapt to Sustained Ammonium Perchlorate Exposure?
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 106-113; doi:10.1093/toxsci/kfh247 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Francisco J. Dieguez-Acuña, William W. Polk, Maureen E. Ellis, P. Lynne Simmonds, John V. Kushleika, and James S. Woods

Nuclear Factor B Activity Determines the Sensitivity of Kidney Epithelial Cells to Apoptosis: Implications for Mercury-Induced Renal Failure
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 114-123; doi:10.1093/toxsci/kfh236 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jianyong Wang, Xiaoli Liu, Robert H. Heflich, and Tao Chen

Time Course of cII Gene Mutant Manifestation in the Liver, Spleen, and Bone Marrow of N-Ethyl-N-Nitrosourea-Treated Big Blue Transgenic Mice
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 124-128; doi:10.1093/toxsci/kfh234 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Castle J. Funatake, Erica A. Dearstyne, Linda B. Steppan, David M. Shepherd, Elena S. Spanjaard, Ann Marshak-Rothstein, and Nancy I. Kerkvliet

Early Consequences of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on the Activation and Survival of Antigen-Specific T Cells
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 129-142; doi:10.1093/toxsci/kfh245 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Xuejun J. Yin, Jane Y. C. Ma, James M. Antonini, Vincent Castranova, and Joseph K. H. Ma

Roles of Reactive Oxygen Species and Heme Oxygenase-1 in Modulation of Alveolar Macrophage-Mediated Pulmonary Immune Responses to Listeria monocytogenes by Diesel Exhaust Particles
ToxSci Advance Access published on August 19, 2004
Toxicol. Sci. 2004 82: 143-153; doi:10.1093/toxsci/kfh255 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Minne B. Heringa, Bart van der Burg, Jan C. H. van Eijkeren, and Joop L. M. Hermens

Xenoestrogenicity in In Vitro Assays Is Not Caused by Displacement of Endogenous Estradiol from Serum Proteins
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 154-163; doi:10.1093/toxsci/kfh238 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

William R. Mundy, Theresa M. Freudenrich, Kevin M. Crofton, and Michael J. DeVito

Accumulation of PBDE-47 in Primary Cultures of Rat Neocortical Cells
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 164-169; doi:10.1093/toxsci/kfh239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Moses T. Bility, Jerry T. Thompson, Richard H. McKee, Raymond M. David, John H. Butala, John P. Vanden Heuvel, and Jeffrey M. Peters

Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (PPARs) by Phthalate Monoesters
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 170-182; doi:10.1093/toxsci/kfh253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jaime L. Treichel, Michele M. Henry, Christine M. B. Skumatz, Janis T. Eells, and Janice M. Burke

Antioxidants and Ocular Cell Type Differences in Cytoprotection from Formic Acid Toxicity in Vitro
ToxSci Advance Access published on August 19, 2004
Toxicol. Sci. 2004 82: 183-192; doi:10.1093/toxsci/kfh256 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

David W. Herr, Sushmita M. Chanda, Jaimie E. Graff, Stanley S. Barone, Jr, Robert P. Beliles, and Daniel L. Morgan

Evaluation of Sensory Evoked Potentials in Long Evans Rats Gestationally Exposed to Mercury (Hg⁰) Vapor
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 193-206; doi:10.1093/toxsci/kfh246 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ilonka A. T. M. Meerts, Hellmuth Lilienthal, Saske Hoving, Johannes H. J. van den Berg, Bert M. Weijers, Åke Bergman, Jan H. Koeman, and Abraham Brouwer

Developmental Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): Long-Term Effects on Brain Development, Behavior, and Brain Stem Auditory Evoked Potentials in Rats
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 207-218; doi:10.1093/toxsci/kfh252 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Chantal J. G. M. Smulders, Regina G. D. M. Van Kleef, Aart de Groot, Cecilia Gotti, and Henk P. M. Vijverberg

A Noncompetitive, Sequential Mechanism for Inhibition of Rat 4ß2 Neuronal Nicotinic Acetylcholine Receptors by Carbamate Pesticides
ToxSci Advance Access published on August 25, 2004
Toxicol. Sci. 2004 82: 219-227; doi:10.1093/toxsci/kfh261 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Joong Koo Kang, Donggeun Sul, Jong Koo Kang, Sang-Yoon Nam, Hae-Joon Kim, and Eunil Lee

Effects of Lead Exposure on the Expression of Phospholipid Hydroperoxidase Glutathione Peroxidase mRNA in the Rat Brain
ToxSci Advance Access published on March 10, 2004
Toxicol. Sci. 2004 82: 228-236; doi:10.1093/toxsci/kfh103 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

E. W. Carney, C. L. Zablotny, M. S. Marty, J. W. Crissman, P. Anderson, M. Woolhiser, and M. Holsapple

The Effects of Feed Restriction during in Utero and Postnatal Development in Rats
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 237-249; doi:10.1093/toxsci/kfh249 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Amy L. Prasch, Warren Heideman, and Richard E. Peterson

ARNT2 Is Not Required for TCDD Developmental Toxicity in Zebrafish
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 250-258; doi:10.1093/toxsci/kfh235 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ilonka A. T. M. Meerts, Saske Hoving, Johannes H. J. van den Berg, Bert M. Weijers, Hans J. Swarts, Eline M. van der Beek, Åke Bergman, Jan H. Koeman, and Abraham Brouwer

Effects of In Utero Exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on Developmental Landmarks, Steroid Hormone Levels, and Female Estrous Cyclicity in Rats
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 259-267; doi:10.1093/toxsci/kfh251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

A. J. Phimister, M. G. Lee, D. Morin, A. R. Buckpitt, and C. G. Plopper

Glutathione Depletion Is a Major Determinant of Inhaled Naphthalene Respiratory Toxicity and Naphthalene Metabolism in Mice
ToxSci Advance Access published on August 19, 2004
Toxicol. Sci. 2004 82: 268-278; doi:10.1093/toxsci/kfh258 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Rory B. Conolly, Julia S. Kimbell, Derek Janszen, Paul M. Schlosser, Darin Kalisak, Julian Preston, and Frederick J. Miller

Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset
ToxSci Advance Access published on July 14, 2004
Toxicol. Sci. 2004 82: 279-296; doi:10.1093/toxsci/kfh223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Weisheng Zhang, Bhagavatula Moorthy, Min Chen, Kathirvel Muthiah, Richard Coffee, Anthony F. Purchio, and David B. West

A Cyp1a2-Luciferase Transgenic CD-1 Mouse Model: Responses to Aryl Hydrocarbons Similar to the Humanized AhR Mice
ToxSci Advance Access published on August 25, 2004
Toxicol. Sci. 2004 82: 297-307; doi:10.1093/toxsci/kfh260 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jason M. Hansen, Walter H. Watson, and Dean P. Jones

Compartmentation of Nrf-2 Redox Control: Regulation of Cytoplasmic Activation by Glutathione and DNA Binding by Thioredoxin-1
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 308-317; doi:10.1093/toxsci/kfh231 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Victoria E. Richards, Binh Chau, M. Randy White, and Charlene A. McQueen

Hepatic Gene Expression and Lipid Homeostasis in C57Bl/6 Mice Exposed to Hydrazine or Acetylhydrazine
ToxSci Advance Access published on July 28, 2004
Toxicol. Sci. 2004 82: 318-332; doi:10.1093/toxsci/kfh232 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy M. O'Brien and Kendall B. Wallace

Mitochondrial Permeability Transition as the Critical Target of N-Acetyl Perfluorooctane Sulfonamide Toxicity in Vitro
ToxSci Advance Access published on August 13, 2004
Toxicol. Sci. 2004 82: 333-340; doi:10.1093/toxsci/kfh244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joseph Milano, Jenny McKay, Claude Dagenais, Linda Foster-Brown, Francois Pognan, Reto Gadient, Robert T. Jacobs, Anna Zacco, Barry Greenberg, and Paul J. Ciaccio

Modulation of Notch Processing by -Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation
ToxSci Advance Access published on August 19, 2004
Toxicol. Sci. 2004 82: 341-358; doi:10.1093/toxsci/kfh254 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

ERRATA:

Julie R. Thibodeaux, Roger G. Hanson, John M. Rogers, Brian E. Grey, Brenda D. Barbee, Judy H. Richards, John L. Butenhoff, Lisa A. Stevenson, and Christopher Lau

Exposure to Perfluorooctane Sulfonate during Pregnancy in Rat and Mouse: Maternal and Prenatal Evaluations
Toxicol. Sci. 2004 82: 359; doi:10.1093/toxsci/kfh280 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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