Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Bruce A. Fowler

Altered Nuclear Factor Kappa-B Activity and Mercury-Induced Kidney Tubule Cell Apoptosis: Implications for Renal Failure
Toxicol. Sci. 2004 82: 361-362; doi:10.1093/toxsci/kfh303 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

John R. Bucher and Christopher Portier

Human Carcinogenic Risk Evaluation, Part V: The National Toxicology Program Vision for Assessing the Human Carcinogenic Hazard of Chemicals
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 363-366; doi:10.1093/toxsci/kfh293 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Lynette K. Rogers, Toshiya Tamura, Bryan J. Rogers, Stephen E. Welty, Thomas N. Hansen, and Charles V. Smith

Analyses of Glutathione Reductase Hypomorphic Mice Indicate a Genetic Knockout
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 367-373; doi:10.1093/toxsci/kfh268 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Grace L. Guo, Jeff S. Moffit, Christopher J. Nicol, Jerrold M. Ward, Lauren A. Aleksunes, Angela L. Slitt, Steven A. Kliewer, Jose E. Manautou, and Frank J. Gonzalez

Enhanced Acetaminophen Toxicity by Activation of the Pregnane X Receptor
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 374-380; doi:10.1093/toxsci/kfh286 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Deborah A. Keys, Irvin R. Schultz, Deirdre A. Mahle, and Jeffrey W. Fisher

A Quantitative Description of Suicide Inhibition of Dichloroacetic Acid in Rats and Mice
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 381-393; doi:10.1093/toxsci/kfh276 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. L. Butenhoff, G. L. Kennedy, Jr, P. M. Hinderliter, P. H. Lieder, R. Jung, K. J. Hansen, G. S. Gorman, P. E. Noker, and P. J. Thomford

Pharmacokinetics of Perfluorooctanoate in Cynomolgus Monkeys
ToxSci Advance Access published on October 6, 2004
Toxicol. Sci. 2004 82: 394-406; doi:10.1093/toxsci/kfh302 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy R. Fennell, Wojciech L. Krol, Susan C. J. Sumner, and Rodney W. Snyder

Pharmacokinetics of Dibutylphthalate in Pregnant Rats
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 407-418; doi:10.1093/toxsci/kfh294 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Balázs Németi and Zoltán Gregus

Glutathione-Dependent Reduction of Arsenate in Human Erythrocytes—a Process Independent of Purine Nucleoside Phosphorylase
ToxSci Advance Access published on October 6, 2004
Toxicol. Sci. 2004 82: 419-428; doi:10.1093/toxsci/kfh301 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Jeanelle M. Martinez, Seung Joon Baek, Donna M. Mays, Patricia K. Tithof, Thomas E. Eling, and Nigel J. Walker

EGR1 Is a Novel Target for AhR Agonists in Human Lung Epithelial Cells
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 429-435; doi:10.1093/toxsci/kfh272 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Julie Marc, Robert Bellé, Julia Morales, Patrick Cormier, and Odile Mulner-Lorillon

Formulated Glyphosate Activates the DNA-Response Checkpoint of the Cell Cycle Leading to the Prevention of G2/M Transition
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 436-442; doi:10.1093/toxsci/kfh281 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Ken Ohno, Naohiro Araki, Toshihiko Yanase, Hajime Nawata, and Mitsuru Iida

A Novel Nonradioactive Method for Measuring Aromatase Activity Using a Human Ovarian Granulosa-Like Tumor Cell Line and an Estrone ELISA
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 443-450; doi:10.1093/toxsci/kfh292 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Geun-Shik Lee, Kyung-Chul Choi, Hoe-Jin Kim, and Eui-Bae Jeung

Effect of Genistein As a Selective Estrogen Receptor Beta Agonist on the Expression of Calbindin-D_9k in the Uterus of Immature Rats
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 451-457; doi:10.1093/toxsci/kfh296 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Ashby and J. Odum

Gene Expression Changes in the Immature Rat Uterus: Effects of Uterotrophic and Sub-Uterotrophic Doses of Bisphenol A
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 458-467; doi:10.1093/toxsci/kfh283 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Malgorzata M. Brzóska and Janina Moniuszko-Jakoniuk

Low-Level Exposure to Cadmium during the Lifetime Increases the Risk of Osteoporosis and Fractures of the Lumbar Spine in the Elderly: Studies on a Rat Model of Human Environmental Exposure
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 468-477; doi:10.1093/toxsci/kfh275 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Xing Cui, Yayoi Kobayashi, Toru Hayakawa, and Seishiro Hirano

Arsenic Speciation in Bile and Urine Following Oral and Intravenous Exposure to Inorganic and Organic Arsenics in Rats
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 478-487; doi:10.1093/toxsci/kfh265 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. K. Peters, K. van Londen, Å. Bergman, J. Bohonowych, M. S. Denison, M. van den Berg, and J. T. Sanderson

Effects of Polybrominated Diphenyl Ethers on Basal and TCDD-Induced Ethoxyresorufin Activity and Cytochrome P450-1A1 Expression in MCF-7, HepG2, and H4IIE Cells
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 488-496; doi:10.1093/toxsci/kfh284 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

W. Kurt Rieben, Jr. and Roger A. Coulombe, Jr.

DNA Cross-Linking by Dehydromonocrotaline Lacks Apparent Base Sequence Preference
ToxSci Advance Access published on August 25, 2004
Toxicol. Sci. 2004 82: 497-503; doi:10.1093/toxsci/kfh262 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

D. R. Germolec, M. Kashon, A. Nyska, C. F. Kuper, C. Portier, C. Kommineni, K. A. Johnson, and M. I. Luster

The Accuracy of Extended Histopathology to Detect Immunotoxic Chemicals
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 504-514; doi:10.1093/toxsci/kfh271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Unni Cecilie Nygaard, Mari Samuelsen, Audun Aase, and Martinus Løvik

The Capacity of Particles to Increase Allergic Sensitization Is Predicted by Particle Number and Surface Area, Not by Particle Mass
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 515-524; doi:10.1093/toxsci/kfh287 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Erik J. Suuronen, Christopher R. McLaughlin, Peter K. Stys, Masatsugu Nakamura, Rejean Munger, and May Griffith

Functional Innervation in Tissue Engineered Models for In Vitro Study and Testing Purposes
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 525-533; doi:10.1093/toxsci/kfh270 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alison E. M. Vickers, Muriel Saulnier, Elba Cruz, Marjolijn T. Merema, Kristine Rose, Philip Bentley, and Peter Olinga

Organ Slice Viability Extended for Pathway Characterization: An in Vitro Model to Investigate Fibrosis
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 534-544; doi:10.1093/toxsci/kfh285 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Chantal J. G. M. Smulders, Tjerk J. H. Bueters, Silvia Vailati, Regina G. D. M. van Kleef, and Henk P. M. Vijverberg

Block of Neuronal Nicotinic Acetylcholine Receptors by Organophosphate Insecticides
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 545-554; doi:10.1093/toxsci/kfh269 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Emma Ankarberg, Anders Fredriksson, and Per Eriksson

Increased Susceptibility to Adult Paraoxon Exposure in Mice Neonatally Exposed to Nicotine
ToxSci Advance Access published on September 8, 2004
Toxicol. Sci. 2004 82: 555-561; doi:10.1093/toxsci/kfh274 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Rogers, G. Schmuck, G. Scholz, and D. C. Williams

c-fos mRNA Expression in Rat Cortical Neurons During Glutamate-Mediated Excitotoxicity
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 562-569; doi:10.1093/toxsci/kfh279 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. C. Scallet, R. L. Divine, R. R. Newbold, and K. B. Delclos

Increased Volume of the Calbindin D28k-Labeled Sexually Dimorphic Hypothalamus in Genistein and Nonylphenol-Treated Male Rats
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 570-576; doi:10.1093/toxsci/kfh297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John J. Widholm, Sherilyn Villareal, Richard F. Seegal, and Susan L. Schantz

Spatial Alternation Deficits Following Developmental Exposure to Aroclor 1254 and/or Methylmercury in Rats
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 577-589; doi:10.1093/toxsci/kfh290 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Hongbin Xu, Nongnuj Tanphaichitr, Poh-Gek Forkert, Araya Anupriwan, Wattana Weerachatyanukul, Renaud Vincent, Arthur Leader, and Michael G. Wade

Exposure to Trichloroethylene and its Metabolites Causes Impairment of Sperm Fertilizing Ability in Mice
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 590-597; doi:10.1093/toxsci/kfh277 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mari S. Golub, Casey E. Hogrefe, Stacey L. Germann, and Christopher P. Jerome

Endocrine Disruption in Adolescence: Immunologic, Hematologic, and Bone Effects in Monkeys
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 598-607; doi:10.1093/toxsci/kfh295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Jae Hyuck Sung, Byung-Gil Choi, Seung-Hee Maeng, Soo-Jin Kim, Yong Hyun Chung, Jeong Hee Han, Kyung Seuk Song, Yong Hwan Lee, Yong Bong Cho, Myung-Haing Cho, Kwang Jong Kim, Jin Suk Hyun, and Il Je Yu

Recovery from Welding-Fume-Exposure-Induced Lung Fibrosis and Pulmonary Function Changes in Sprague Dawley Rats
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 608-613; doi:10.1093/toxsci/kfh289 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

James A. Crowell, Peter J. Korytko, Robert L. Morrissey, Tristan D. Booth, and Barry S. Levine

Resveratrol-Associated Renal Toxicity
ToxSci Advance Access published on August 25, 2004
Toxicol. Sci. 2004 82: 614-619; doi:10.1093/toxsci/kfh263 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

M. Reisner, S. Carmeli, M. Werman, and A. Sukenik

The Cyanobacterial Toxin Cylindrospermopsin Inhibits Pyrimidine Nucleotide Synthesis and Alters Cholesterol Distribution in Mice
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 620-627; doi:10.1093/toxsci/kfh267 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael T.N. Møller, Hamid R. Samari, and Per O. Seglen

Toxin-Induced Tail Phosphorylation of Hepatocellular S6 Kinase: Evidence for a Dual Involvement of the AMP-Activated Protein Kinase in S6 Kinase Regulation
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2004 82: 628-637; doi:10.1093/toxsci/kfh273 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Vengellur and J. J. LaPres

The Role of Hypoxia Inducible Factor 1 in Cobalt Chloride Induced Cell Death in Mouse Embryonic Fibroblasts
ToxSci Advance Access published on September 16, 2004
Toxicol. Sci. 2004 82: 638-646; doi:10.1093/toxsci/kfh278 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David C. McMillan, Snehal D. Sarvate, John E. Oatis, Jr., and David J. Jollow

Role of Oxidant Stress in Lawsone-Induced Hemolytic Anemia
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2004 82: 647-655; doi:10.1093/toxsci/kfh288 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel S. Perrien, Elizabeth C. Wahl, William R. Hogue, Ulrich Feige, James Aronson, Martin J. J. Ronis, Thomas M. Badger, and Charles K. Lumpkin, Jr.

IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats
ToxSci Advance Access published on October 6, 2004
Toxicol. Sci. 2004 82: 656-660; doi:10.1093/toxsci/kfi002 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Erratum
Toxicol. Sci. 2004 82: 0; doi:10.1093/toxsci/kfh300 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Erratum
Toxicol. Sci. 2004 82: 0; doi:10.1093/toxsci/kfh304 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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