Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Charles V. Smith

Compartmentalization of Redox Regulation of Cell Responses
Toxicol. Sci. 2005 83: 1-3; doi:10.1093/toxsci/kfi036 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

J. Christopher Corton and Paula J. Lapinskas

Peroxisome Proliferator-Activated Receptors: Mediators of Phthalate Ester-Induced Effects in the Male Reproductive Tract?
ToxSci Advance Access published on October 20, 2004
Toxicol. Sci. 2005 83: 4-17; doi:10.1093/toxsci/kfi011 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

FORUM:

Michael P. Holsapple, Leigh Ann Burns-Naas, Kenneth L. Hastings, Gregory S. Ladics, Amy L. Lavin, Susan L. Makris, Yung Yang, and Michael I. Luster

A Proposed Testing Framework for Developmental Immunotoxicology (DIT)
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2005 83: 18-24; doi:10.1093/toxsci/kfh299 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Elaine A. Merrill, Rebecca A. Clewell, Peter J. Robinson, Annie M. Jarabek, Jeffery M. Gearhart, Teresa R. Sterner, and Jeffrey W. Fisher

PBPK Model for Radioactive Iodide and Perchlorate Kinetics and Perchlorate-Induced Inhibition of Iodide Uptake in Humans
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 25-43; doi:10.1093/toxsci/kfi017 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lauren M. Aleksunes, Angela M. Slitt, Nathan J. Cherrington, Michael S. Thibodeau, Curtis D. Klaassen, and José E. Manautou

Differential Expression of Mouse Hepatic Transporter Genes in Response to Acetaminophen and Carbon Tetrachloride
ToxSci Advance Access published on October 20, 2004
Toxicol. Sci. 2005 83: 44-52; doi:10.1093/toxsci/kfi013 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

CARCINOGENESIS:

Jan Vondrácek, Miroslav Machala, Vítezslav Bryja, Katerina Chramostová, Pavel Krcmár, Cornelia Dietrich, Ales Hampl, and Alois Kozubík

Aryl Hydrocarbon Receptor-Activating Polychlorinated Biphenyls and Their Hydroxylated Metabolites Induce Cell Proliferation in Contact-Inhibited Rat Liver Epithelial Cells
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 53-63; doi:10.1093/toxsci/kfi009 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katsuhiko Yoshizawa, Nigel J. Walker, Micheal P. Jokinen, Amy E. Brix, Donald M. Sells, Tiwanda Marsh, Michael E. Wyde, Denise Orzech, Joseph K. Haseman, and Abraham Nyska

Gingival Carcinogenicity in Female Harlan Sprague-Dawley Rats following Two-Year Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-Like Compounds
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 64-77; doi:10.1093/toxsci/kfi016 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Yong-Woo Jung, Eui-Ju Hong, Kyung-Chul Choi, and Eui-Bae Jeung

Novel Progestogenic Activity of Environmental Endocrine Disruptors in the Upregulation of Calbindin-D_9k in an Immature Mouse Model
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 78-88; doi:10.1093/toxsci/kfi015 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Trine Reistad, Espen Mariussen, and Frode Fonnum

The Effect of a Brominated Flame Retardant, Tetrabromobisphenol-A, on Free Radical Formation in Human Neutrophil Granulocytes: The Involvement of the MAP Kinase Pathway and Protein Kinase C
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2005 83: 89-100; doi:10.1093/toxsci/kfh298 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Carlton L. Schwab, Ruping Fan, Qiang Zheng, L. Peyton Myers, Pamela Hébert, and Stephen B. Pruett

Modeling and Predicting Stress-Induced Immunosuppression in Mice Using Blood Parameters
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 101-113; doi:10.1093/toxsci/kfi014 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Mariana Borgognone, Leonardo M. Pérez, Cecilia L. Basiglio, Justina E. Ochoa, and Marcelo G. Roma

Signaling Modulation of Bile Salt-Induced Necrosis in Isolated Rat Hepatocytes
ToxSci Advance Access published on October 20, 2004
Toxicol. Sci. 2005 83: 114-125; doi:10.1093/toxsci/kfi012 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Antje S. Neave, Sussi M. Sarup, Michel Seidelin, Fritz Duus, and Ole Vang

Characterization of the N-methoxyindole-3-carbinol (NI3C)–Induced Cell Cycle Arrest in Human Colon Cancer Cell Lines
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 126-135; doi:10.1093/toxsci/kfi008 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Edwin Sonneveld, Hendrina J. Jansen, Jacoba A. C. Riteco, Abraham Brouwer, and Bart van der Burg

Development of Androgen- and Estrogen-Responsive Bioassays, Members of a Panel of Human Cell Line-Based Highly Selective Steroid-Responsive Bioassays
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 136-148; doi:10.1093/toxsci/kfi005 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Hwei-Hsien Chen, Yi-Ruu Lin, Quan-Guo Peng, and Ming-Huan Chan

Effects of Trichloroethylene and Perchloroethylene on Muscle Contractile Responses and Epithelial Prostaglandin Release and Acetylcholinesterase Activity in Swine Trachea
ToxSci Advance Access published on October 20, 2004
Toxicol. Sci. 2005 83: 149-154; doi:10.1093/toxsci/kfi010 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kevin S. Harrod, Richard J. Jaramillo, Jennifer A. Berger, Andrew P. Gigliotti, Steven K. Seilkop, and Matthew D. Reed

Inhaled Diesel Engine Emissions Reduce Bacterial Clearance and Exacerbate Lung Disease to Pseudomonas aeruginosa Infection In Vivo
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 155-165; doi:10.1093/toxsci/kfi007 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pamela J. Lein and Allison D. Fryer

Organophosphorus Insecticides Induce Airway Hyperreactivity by Decreasing Neuronal M2 Muscarinic Receptor Function Independent of Acetylcholinesterase Inhibition
ToxSci Advance Access published on October 6, 2004
Toxicol. Sci. 2005 83: 166-176; doi:10.1093/toxsci/kfi001 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Moung S. Lee, Thomas H. Faller, Paul E. Kreuzer, Winfried Kessler, György A. Csanády, Christian Pütz, Melva N. Ríos-Blanco, Lynn H. Pottenger, Dan Segerbäck, Siv Osterman-Golkar, James A. Swenberg, and Johannes G. Filser

Propylene Oxide in Blood and Soluble Nonprotein Thiols in Nasal Mucosa and Other Tissues of Male Fischer 344/N Rats Exposed to Propylene Oxide Vapors—Relevance of Glutathione Depletion for Propylene Oxide-Induced Rat Nasal Tumors
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 177-189; doi:10.1093/toxsci/kfi006 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Yoshiya Ito, Edward R. Abril, Nancy W. Bethea, and Robert S. McCuskey

Inhibition of Matrix Metalloproteinases Minimizes Hepatic Microvascular Injury in Response to Acetaminophen in Mice
ToxSci Advance Access published on September 29, 2004
Toxicol. Sci. 2005 83: 190-196; doi:10.1093/toxsci/kfh291 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ning Li and Curtis D. Klaassen

Lipopolysaccharide-Induced Down-Regulation of Organic Anion Transporting Polypeptide 4 (Oatp4; Slc21a10) Is Independent of Tumor Necrosis Factor-, Interleukin-1ß, Interleukin-6, or Inducible Nitric Oxide Synthase
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 83: 197-203; doi:10.1093/toxsci/kfi003 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

William R. Mundy, Theresa M. Freudenrich, Kevin M. Crofton, and Michael J. DeVito

Accumulation of PBDE-47 in Primary Cultures of Rat Neocortical Cells
Toxicol. Sci. 2005 83: 204; doi:10.1093/toxsci/kfi029 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Ken Ohno, Naohiro Araki, Toshihiko Yanase, Hajime Nawata, and Mitsuru Iida

A Novel Nonradioactive Method for Measuring Aromatase Activity Using a Human Ovarian Granulosa-Like Tumor Cell Line and an Estrone ELISA
Toxicol. Sci. 2005 83: 204; doi:10.1093/toxsci/kfi037 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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