Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Michael L. Cunningham and Lois Lehman-McKeeman

Applying Toxicogenomics in Mechanistic and Predictive Toxicology
Toxicol. Sci. 2005 83: 205-206; doi:10.1093/toxsci/kfi047 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Daniel C. Kemp, Maciej J. Zamek-Gliszczynski, and Kim L. R. Brouwer

Xenobiotics Inhibit Hepatic Uptake and Biliary Excretion of Taurocholate in Rat Hepatocytes
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 207-214; doi:10.1093/toxsci/kfi020 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. F. Staskal, J. J. Diliberto, M. J. DeVito, and L. S. Birnbaum

Toxicokinetics of BDE 47 in Female Mice: Effect of Dose, Route of Exposure, and Time
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 215-223; doi:10.1093/toxsci/kfi018 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. M. Rappaport, L. L. Kupper, and Y. S. Lin

On the Importance of Exposure Variability to the Doses of Volatile Organic Compounds
ToxSci Advance Access published on November 17, 2004
Toxicol. Sci. 2005 83: 224-236; doi:10.1093/toxsci/kfi039 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENESIS:

Min Wei, Lora Arnold, Martin Cano, and Samuel M. Cohen

Effects of Co-administration of Antioxidants and Arsenicals on the Rat Urinary Bladder Epithelium
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 237-245; doi:10.1093/toxsci/kfi033 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Martina Plísková, Jan Vondrácek, Borivoj Vojtesek, Alois Kozubík, and Miroslav Machala

Deregulation of Cell Proliferation by Polycyclic Aromatic Hydrocarbons in Human Breast Carcinoma MCF-7 Cells Reflects Both Genotoxic and Nongenotoxic Events
ToxSci Advance Access published on November 17, 2004
Toxicol. Sci. 2005 83: 246-256; doi:10.1093/toxsci/kfi040 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Marjoke Heneweer, Martine Muusse, Milou Dingemans, Paul C. de Jong, Martin van den Berg, and J. Thomas Sanderson

Co-culture of Primary Human Mammary Fibroblasts and MCF-7 Cells as an In Vitro Breast Cancer Model
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 257-263; doi:10.1093/toxsci/kfi025 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard H. M. M. Schreurs, Edwin Sonneveld, Jenny H. J. Jansen, Willem Seinen, and Bart van der Burg

Interaction of Polycyclic Musks and UV Filters with the Estrogen Receptor (ER), Androgen Receptor (AR), and Progesterone Receptor (PR) in Reporter Gene Bioassays
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 264-272; doi:10.1093/toxsci/kfi035 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Stefan Nierkens, Marloes Aalbers, Marianne Bol, Femke van Wijk, Ine Hassing, and Raymond Pieters

Development of an Oral Exposure Mouse Model to Predict Drug-Induced Hypersensitivity Reactions by Using Reporter Antigens
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 273-281; doi:10.1093/toxsci/kfi021 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Hiroshi Sawada, Kenji Takami, and Satoru Asahi

A Toxicogenomic Approach to Drug-Induced Phospholipidosis: Analysis of Its Induction Mechanism and Establishment of a Novel in Vitro Screening System
ToxSci Advance Access published on September 1, 2004
Toxicol. Sci. 2005 83: 282-292; doi:10.1093/toxsci/kfh264 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rawiwan Maniratanachote, Keiichi Minami, Miki Katoh, Miki Nakajima, and Tsuyoshi Yokoi

Chaperone Proteins Involved in Troglitazone-Induced Toxicity in Human Hepatoma Cell Lines
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 293-302; doi:10.1093/toxsci/kfi022 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Eric S. Peeples, Lawrence M. Schopfer, Ellen G. Duysen, Reggie Spaulding, Troy Voelker, Charles M. Thompson, and Oksana Lockridge

Albumin, a New Biomarker of Organophosphorus Toxicant Exposure, Identified by Mass Spectrometry
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 303-312; doi:10.1093/toxsci/kfi023 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jiang Li, Delinda Johnson, Marcus Calkins, Lynda Wright, Clive Svendsen, and Jeffrey Johnson

Stabilization of Nrf2 by tBHQ Confers Protection against Oxidative Stress-Induced Cell Death in Human Neural Stem Cells
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 313-328; doi:10.1093/toxsci/kfi027 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Victor J. Johnson, Sang-Hyun Kim, and Raghubir P. Sharma

Aluminum-Maltolate Induces Apoptosis and Necrosis in Neuro-2a Cells: Potential Role for p53 Signaling
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 329-339; doi:10.1093/toxsci/kfi028 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mary A. Williamson, Thomas A. Gasiewicz, and Lisa A. Opanashuk

Aryl Hydrocarbon Receptor Expression and Activity in Cerebellar Granule Neuroblasts: Implications for Development and Dioxin Neurotoxicity
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 340-348; doi:10.1093/toxsci/kfi031 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Zengli Yu, Jiuxiang Lin, Ying Xiao, Jing Han, Xingzhong Zhang, Haichao Jia, Yunan Tang, and Yong Li

Induction of Cell-Cycle Arrest by all-trans Retinoic Acid in Mouse Embryonic Palatal Mesenchymal (MEPM) Cells
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 349-354; doi:10.1093/toxsci/kfi030 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel A. Symonds, Dragana Tomic, Kimberly P. Miller, and Jodi A. Flaws

Methoxychlor Induces Proliferation of the Mouse Ovarian Surface Epithelium
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 355-362; doi:10.1093/toxsci/kfi024 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rebecca J. Sommer, Adam J. Hume, Jessica M. Ciak, John J. VanNostrand, Megan Friggens, and Mary K. Walker

Early Developmental 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure Decreases Chick Embryo Heart Chronotropic Response to Isoproterenol but Not to Agents Affecting Signals Downstream of the Beta-Adrenergic Receptor
ToxSci Advance Access published on November 24, 2004
Toxicol. Sci. 2005 83: 363-371; doi:10.1093/toxsci/kfi041 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Li-Jun Chen, Yinzhi Zhao, Song Gao, Iih-Nan Chou, Paul Toselli, Phillip Stone, and Wande Li

Downregulation of Lysyl Oxidase and Upregulation of Cellular Thiols in Rat Fetal Lung Fibroblasts Treated with Cigarette Smoke Condensate
ToxSci Advance Access published on October 27, 2004
Toxicol. Sci. 2005 83: 372-379; doi:10.1093/toxsci/kfi019 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. B. Morris, W. S. Wilkie, and D. J. Shusterman

Acute Respiratory Responses of the Mouse to Chlorine
ToxSci Advance Access published on November 17, 2004
Toxicol. Sci. 2005 83: 380-387; doi:10.1093/toxsci/kfi038 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Abraham Nyska, Elizabeth Murphy, Julie F. Foley, Bradley J. Collins, John Petranka, Reuben Howden, Paul Hanlon, and June K. Dunnick

Acute Hemorrhagic Myocardial Necrosis and Sudden Death of Rats Exposed to a Combination of Ephedrine and Caffeine
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 83: 388-396; doi:10.1093/toxsci/kfi034 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Sun-Hee Kim, Yun-Hee Kim, Kum-Joo Shin, Yong-Seok Oh, Chang Sup Lee, Kyung-Ok Kang, Sung Ho Ryu, and Pann-Ghill Suh

2,2',4,6,6'-Pentachlorobiphenyl-Induced Apoptosis Is Limited by Cyclooxygenase-2 Induction
ToxSci Advance Access published on November 3, 2004
Toxicol. Sci. 2005 83: 397-404; doi:10.1093/toxsci/kfi026 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Nicole V. Soucy, Michael A. Ihnat, Chandrashekhar D. Kamat, Linda Hess, Mark J. Post, Linda R. Klei, Callie Clark, and Aaron Barchowsky

Arsenic Stimulates Angiogenesis and Tumorigenesis In Vivo
Toxicol. Sci. 2005 83: 405; doi:10.1093/toxsci/kfi054 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Katsuhiko Yoshizawa, Nigel J. Walker, Micheal P. Jokinen, Amy E. Brix, Donald M. Sells, Tiwanda Marsh, Michael E. Wyde, Denise Orzech, Joseph K. Haseman, and Abraham Nyska

Gingival Carcinogenicity in Female Harlan Sprague-Dawley Rats Following Two-year Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-like Compounds
Toxicol. Sci. 2005 83: 405-406; doi:10.1093/toxsci/kfi056 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Ken Ohno, Naohiro Araki, Toshihiko Yanase, Hajime Nawata, and Mitsuru Iida

A Novel Nonradioactive Method for Measuring Aromatase Activity Using a Human Ovarian Granulosa-Like Tumor Cell Line and an Estrone ELISA
Toxicol. Sci. 2005 83: 406; doi:10.1093/toxsci/kfi058 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Antje S. Neave, Sussi M. Sarup, Michel Seidelin, Fritz Duus, and Ole Vang

Characterization of the N-methoxyindole-3-carbinol (NI3C)-induced Cell Cycle Arrest in Human Colon Cancer Cell Lines
Toxicol. Sci. 2005 83: 407-409; doi:10.1093/toxsci/kfi059 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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