Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Lorenz R. Rhomberg

Seeking Optimal Design for Animal Bioassay Studies
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 1-3; doi:10.1093/toxsci/kfi076 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Silvina S. M. Villanueva, María L. Ruiz, Marcelo G. Luquita, Enrique J. Sánchez Pozzi, Viviana A. Catania, and Aldo D. Mottino

Involvement of Mrp2 in Hepatic and Intestinal Disposition of Dinitrophenyl-S-glutathione in Partially Hepatectomized Rats
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 4-11; doi:10.1093/toxsci/kfi053 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

David C. Dorman, Anna M. McElveen, Marianne W. Marshall, Carl U. Parkinson, R. Arden James, Melanie F. Struve, and Brian A. Wong

Tissue Manganese Concentrations in Lactating Rats and Their Offspring Following Combined in Utero and Lactation Exposure to Inhaled Manganese Sulfate
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 12-21; doi:10.1093/toxsci/kfi060 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Morimichi Hayashi, Toru Tamura, Junji Kuroda, Hideki Ohnota, Nobuo Shibata, Masuo Akahane, Yoko Kashida, and Kunitoshi Mitsumori

Different Inhibitory Effects in the Early and Late Phase of Treatment with KAT-681, a Liver-Selective Thyromimetic, on Rat Hepatocarcinogenesis Induced by 2-Acetylaminofluorene and Partial Hepatectomy after Diethylnitrosamine Initiation
ToxSci Advance Access published on November 24, 2004
Toxicol. Sci. 2005 84: 22-28; doi:10.1093/toxsci/kfi044 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Yumiko Kudo and Kiyoshi Yamauchi

In Vitro and in Vivo Analysis of the Thyroid Disrupting Activities of Phenolic and Phenol Compounds in Xenopus laevis
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 29-37; doi:10.1093/toxsci/kfi049 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tammy E. Stoker, Sally D. Perreault, Katrine Bremser, Renee S. Marshall, Ashley Murr, and Ralph L. Cooper

Acute Exposure to Molinate Alters Neuroendocrine Control of Ovulation in the Rat
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 38-48; doi:10.1093/toxsci/kfi064 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Sundaram Arulmozhiraja, Fujio Shiraishi, Tameo Okumura, Mitsuru Iida, Hidetaka Takigami, John S. Edmonds, and Masatoshi Morita

Structural Requirements for the Interaction of 91 Hydroxylated Polychlorinated Biphenyls with Estrogen and Thyroid Hormone Receptors
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 49-62; doi:10.1093/toxsci/kfi063 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Henrik Sundberg, Rasha Ishaq, Gun Åkerman, Ulla Tjärnlund, Yngve Zebühr, Maria Linderoth, Dag Broman, and Lennart Balk

A Bio-Effect Directed Fractionation Study for Toxicological and Chemical Characterization of Organic Compounds in Bottom Sediment
ToxSci Advance Access published on December 22, 2004
Toxicol. Sci. 2005 84: 63-72; doi:10.1093/toxsci/kfi067 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Grantley D. Charles, Pamela J. Spencer, Melissa R. Schisler, Maria Cifone, Robert A. Budinsky, and B. Bhaskar Gollapudi

Mode of Mutagenic Action for the Biocide Bioban CS-1246 in Mouse Lymphoma Cells and Implications for Its In Vivo Mutagenic Potential
ToxSci Advance Access published on November 24, 2004
Toxicol. Sci. 2005 84: 73-80; doi:10.1093/toxsci/kfi042 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hanspeter Witschi

Carcinogenic Activity of Cigarette Smoke Gas Phase and Its Modulation by Beta-Carotene and N-Acetylcysteine
ToxSci Advance Access published on November 24, 2004
Toxicol. Sci. 2005 84: 81-87; doi:10.1093/toxsci/kfi043 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Joanna M. Matheson, Victor J. Johnson, Velayudhan Vallyathan, and Michael I. Luster

Exposure and Immunological Determinants in a Murine Model for Toluene Diisocyanate (TDI) Asthma
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 88-98; doi:10.1093/toxsci/kfi050 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joanna M. Matheson, Victor J. Johnson, and Michael I. Luster

Immune Mediators in a Murine Model for Occupational Asthma: Studies with Toluene Diisocyanate
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 99-109; doi:10.1093/toxsci/kfi051 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Jared W. Allen, Salman R. Khetani, and Sangeeta N. Bhatia

In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 110-119; doi:10.1093/toxsci/kfi052 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tad E. Eichler, Richard F. Ransom, and William E. Smoyer

Differential Induction of Podocyte Heat Shock Proteins by Prolonged Single and Combination Toxic Metal Exposure
ToxSci Advance Access published on December 8, 2004
Toxicol. Sci. 2005 84: 120-128; doi:10.1093/toxsci/kfi048 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vicente Santa Cruz, Tammy R. Dugas, and Mary F. Kanz

Mitochondrial Dysfunction Occurs before Transport or Tight Junction Deficits in Biliary Epithelial Cells Exposed to Bile from Methylenedianiline-Treated Rats
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 129-138; doi:10.1093/toxsci/kfi061 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Nikolay M. Filipov, Richard F. Seegal, and David A. Lawrence

Manganese Potentiates In Vitro Production of Proinflammatory Cytokines and Nitric Oxide by Microglia Through a Nuclear Factor kappa B–Dependent Mechanism
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 139-148; doi:10.1093/toxsci/kfi055 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cary G. Coburn, Elizabeth R. Gillard, and Margarita C. Currás-Collazo

Dietary Exposure to Aroclor 1254 Alters Central and Peripheral Vasopressin Release in Response to Dehydration in the Rat
ToxSci Advance Access published on December 1, 2004
Toxicol. Sci. 2005 84: 149-156; doi:10.1093/toxsci/kfi046 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

V. M. Rodríguez, L. M. Del Razo, J. H. Limón-Pacheco, M. Giordano, L. C. Sánchez-Peña, Eileen Uribe-Querol, G. Gutiérrez-Ospina, and M. E. Gonsebatt

Glutathione Reductase Inhibition and Methylated Arsenic Distribution in Cd1 Mice Brain and Liver
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 157-166; doi:10.1093/toxsci/kfi057 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Wout Slob, Mirjam Moerbeek, Eija Rauniomaa, and Aldert H. Piersma

A Statistical Evaluation of Toxicity Study Designs for the Estimation of the Benchmark Dose in Continuous Endpoints
ToxSci Advance Access published on October 13, 2004
Toxicol. Sci. 2005 84: 167-185; doi:10.1093/toxsci/kfi004 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

C. Hastings, T. Rand, H. T. Bergen, J. A. Thliveris, A. R. Shaw, G. A. Lombaert, H. H. Mantsch, B. L. Giles, S. Dakshinamurti, and J. E. Scott

Stachybotrys chartarum Alters Surfactant-Related Phospholipid Synthesis and CTP:Cholinephosphate Cytidylyltransferase Activity in Isolated Fetal Rat Type II Cells
ToxSci Advance Access published on December 1, 2004
Toxicol. Sci. 2005 84: 186-194; doi:10.1093/toxsci/kfi045 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kenneth E. McMartin and Kendall B. Wallace

Calcium Oxalate Monohydrate, a Metabolite of Ethylene Glycol, Is Toxic for Rat Renal Mitochondrial Function
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 195-200; doi:10.1093/toxsci/kfi062 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cathleen Cover, Peter Fickert, Tamara R. Knight, Andrea Fuchsbichler, Anwar Farhood, Michael Trauner, and Hartmut Jaeschke

Pathophysiological Role of Poly(ADP-Ribose) Polymerase (PARP) Activation during Acetaminophen-Induced Liver Cell Necrosis in Mice
ToxSci Advance Access published on December 15, 2004
Toxicol. Sci. 2005 84: 201-208; doi:10.1093/toxsci/kfi065 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes
Toxicol. Sci. 2005 84: 209; doi:10.1093/toxsci/kfi078 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.