Toxicological Sciences

PROFILES IN TOXICOLOGY:

William Stott and James Bus

Philip G. Watanabe
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 84: 211; doi:10.1093/toxsci/kfi098 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Jie Liu and Michael P. Waalkes

Focal Adhesion Kinase as a Potential Target in Arsenic Toxicity
Toxicol. Sci. 2005 84: 212-213; doi:10.1093/toxsci/kfi111 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Shakil A. Saghir and Irvin R. Schultz

Toxicokinetics and Oral Bioavailability of Halogenated Acetic Acids Mixtures in Naïve and GSTzeta-Depleted Rats
ToxSci Advance Access published on December 29, 2004
Toxicol. Sci. 2005 84: 214-224; doi:10.1093/toxsci/kfi070 [Abstract] [FREE Full Text] [PDF] Supplementary DataSupplementary Data - color figures [Request Permissions]  

D. F. Staskal, J. J. Diliberto, M. J. DeVito, and L. S. Birnbaum

Inhibition of Human and Rat CYP1A2 by TCDD and Dioxin-like Chemicals
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 225-231; doi:10.1093/toxsci/kfi090 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Harvey Wong, Lois D. Lehman-McKeeman, Mary F. Grubb, Scott J. Grossman, Vasanthi M. Bhaskaran, Eric G. Solon, Helen S. L. Shen, Ronald J. Gerson, Bruce D. Car, Bitao Zhao, and Brian Gemzik

Increased Hepatobiliary Clearance of Unconjugated Thyroxine Determines DMP 904-Induced Alterations in Thyroid Hormone Homeostasis in Rats
ToxSci Advance Access published on January 26, 2005
Toxicol. Sci. 2005 84: 232-242; doi:10.1093/toxsci/kfi094 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Akiyoshi Nishikawa, Takayoshi Imazawa, Yuichi Kuroiwa, Yasuki Kitamura, Keita Kanki, Yuji Ishii, Takashi Umemura, and Masao Hirose

Induction of Colon Tumors in C57BL/6J Mice Fed MeIQx, IQ, or PhIP Followed by Dextran Sulfate Sodium Treatment
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 243-248; doi:10.1093/toxsci/kfi079 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Shigeyuki Kitamura, Tomoharu Suzuki, Seigo Sanoh, Ryuki Kohta, Norimasa Jinno, Kazumi Sugihara, Shin'ichi Yoshihara, Nariaki Fujimoto, Hiromitsu Watanabe, and Shigeru Ohta

Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 249-259; doi:10.1093/toxsci/kfi074 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neelakanteswar Aluru, Rick Renaud, John F. Leatherland, and Mathilakath M. Vijayan

Ah Receptor-Mediated Impairment of Interrenal Steroidogenesis Involves StAR Protein and P450scc Gene Attenuation in Rainbow Trout
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 260-269; doi:10.1093/toxsci/kfi077 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Geun-Shik Lee, Hoe-Jin Kim, Yong-Woo Jung, Kyung-Chul Choi, and Eui-Bae Jeung

Estrogen Receptor Pathway Is Involved in the Regulation of Calbindin-D_9k in the Uterus of Immature Rats
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 270-277; doi:10.1093/toxsci/kfi072 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Shannon L. Yancy, Eric A. Shelden, Robert R. Gilmont, and Michael J. Welsh

Sodium Arsenite Exposure Alters Cell Migration, Focal Adhesion Localization and Decreases Tyrosine Phosphorylation of Focal Adhesion Kinase in H9C2 Myoblasts
ToxSci Advance Access published on November 10, 2004
Toxicol. Sci. 2005 84: 278-286; doi:10.1093/toxsci/kfi032 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yan Xu, Thomas J. Cook, and Gregory T. Knipp

Effects of Di-(2-Ethylhexyl)-Phthalate (DEHP) and Its Metabolites on Fatty Acid Homeostasis Regulating Proteins in Rat Placental HRP-1 Trophoblast Cells
ToxSci Advance Access published on January 12, 2005
Toxicol. Sci. 2005 84: 287-300; doi:10.1093/toxsci/kfi083 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ionelia Taranu, Daniela E. Marin, Sandrine Bouhet, Florentina Pascale, Jean-Denis Bailly, J. David Miller, Philippe Pinton, and Isabelle P. Oswald

Mycotoxin Fumonisin B₁ Alters the Cytokine Profile and Decreases the Vaccinal Antibody Titer in Pigs
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 301-307; doi:10.1093/toxsci/kfi086 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Min Ok Song and Jonathan H. Freedman

Activation of Mitogen Activated Protein Kinases by PCB126 (3,3',4,4',5-Pentachlorobiphenyl) in HepG2 Cells
ToxSci Advance Access published on January 12, 2005
Toxicol. Sci. 2005 84: 308-318; doi:10.1093/toxsci/kfi084 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hiroshi Masuno, Jun Iwanami, Teruki Kidani, Kenshi Sakayama, and Katsuhisa Honda

Bisphenol A Accelerates Terminal Differentiation of 3T3-L1 Cells into Adipocytes through the Phosphatidylinositol 3-Kinase Pathway
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 319-327; doi:10.1093/toxsci/kfi088 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Steven A. Bezdecny, Robert A. Roth, and Patricia E. Ganey

Effects of 2,2',4,4'-Tetrachlorobiphenyl on Granulocytic HL-60 Cell Function and Expression of Cyclooxygenase-2
ToxSci Advance Access published on January 26, 2005
Toxicol. Sci. 2005 84: 328-334; doi:10.1093/toxsci/kfi093 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

S. Creton, H. Zhu, and N. J. Gooderham

A Mechanistic Basis for the Role of Cycle Arrest in the Genetic Toxicology of the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 335-343; doi:10.1093/toxsci/kfi075 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Toshiyuki Tsuchiya, Toshiko Tanaka-Kagawa, Hideto Jinno, Hiroshi Tokunaga, Kazunori Sakimoto, Masanori Ando, and Makoto Umeda

Inorganic Arsenic Compounds and Methylated Metabolites Induce Morphological Transformation in Two-Stage BALB/c 3T3 Cell Assay and Inhibit Metabolic Cooperation in V79 Cell Assay
ToxSci Advance Access published on January 12, 2005
Toxicol. Sci. 2005 84: 344-351; doi:10.1093/toxsci/kfi082 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Jason R. Richardson and Janice E. Chambers

Effects of Repeated Oral Postnatal Exposure to Chlorpyrifos on Cholinergic Neurochemistry in Developing Rats
ToxSci Advance Access published on January 12, 2005
Toxicol. Sci. 2005 84: 352-359; doi:10.1093/toxsci/kfi081 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. Carvajal, M. C. Sánchez-Amate, F. Sánchez-Santed, and I. Cubero

Neuroanatomical Targets of the Organophosphate Chlorpyrifos by c-fos Immunolabeling
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 360-367; doi:10.1093/toxsci/kfi092 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Dagmara S. Antkiewicz, C. Geoffrey Burns, Sara A. Carney, Richard E. Peterson, and Warren Heideman

Heart Malformation Is an Early Response to TCDD in Embryonic Zebrafish
ToxSci Advance Access published on January 5, 2005
Toxicol. Sci. 2005 84: 368-377; doi:10.1093/toxsci/kfi073 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Xiaozhong Yu, Jaspreet S. Sidhu, S. Hong, and Elaine M. Faustman

Essential Role of Extracellular Matrix (ECM) Overlay in Establishing the Functional Integrity of Primary Neonatal Rat Sertoli Cell/Gonocyte Co-cultures: An Improved In Vitro Model for Assessment of Male Reproductive Toxicity
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 378-393; doi:10.1093/toxsci/kfi085 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shannon K. Lee and D. N. Rao Veeramachaneni

Subchronic Exposure to Low Concentrations of Di-n-Butyl Phthalate Disrupts Spermatogenesis in Xenopus laevis Frogs
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 84: 394-407; doi:10.1093/toxsci/kfi087 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Iwona Yike, Thomas G. Rand, and Dorr G. Dearborn

Acute Inflammatory Responses to Stachybotrys chartarum in the Lungs of Infant Rats: Time Course and Possible Mechanisms
ToxSci Advance Access published on January 12, 2005
Toxicol. Sci. 2005 84: 408-417; doi:10.1093/toxsci/kfi080 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Mitochondrial Dysfunction Occurs before Transport or Tight Junction Deficits in Biliary Epithelial Cells Exposed to Bile from Methylenedianiline-Treated Rats
Toxicol. Sci. 2005 84: 418; doi:10.1093/toxsci/kfi132 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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