Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT & FORUM:

Bernard A. Schwetz, Lois Lehman-McKeeman, and Linda S. Birnbaum

Toxicological Research Involving Humans: Ethical and Regulatory Considerations
Toxicol. Sci. 2005 85: 419-421; doi:10.1093/toxsci/kfi140 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEWS:

Sebastian Hoffmann and Thomas Hartung

Diagnosis: Toxic! – Trying to Apply Approaches of Clinical Diagnostics and Prevalence in Toxicology Considerations
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 422-428; doi:10.1093/toxsci/kfi099 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

J. G. Teeguarden, P. J. Deisinger, T. S. Poet, J. C. English, W. D. Faber, H. A. Barton, R. A. Corley, and H. J. Clewell, III

Derivation of a Human Equivalent Concentration for n-Butanol Using A Physiologically Based Pharmacokinetic Model for n-Butyl Acetate and Metabolites n-Butanol and n-Butyric Acid
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 429-446; doi:10.1093/toxsci/kfi103 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy R. Fennell, Susan C.J. Sumner, Rodney W. Snyder, Jason Burgess, Rebecca Spicer, William E. Bridson, and Marvin A. Friedman

Metabolism and Hemoglobin Adduct Formation of Acrylamide in Humans
ToxSci Advance Access published on December 29, 2004
Toxicol. Sci. 2005 85: 447-459; doi:10.1093/toxsci/kfi069 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

P. M. Hinderliter, K. D. Thrall, R. A. Corley, L. J. Bloemen, and M. S. Bogdanffy

Validation of Human Physiologically Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 85: 460-467; doi:10.1093/toxsci/kfi091 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

E. M. Kenyon, L. M. Del Razo, and M. F. Hughes

Tissue Distribution and Urinary Excretion of Inorganic Arsenic and Its Methylated Metabolites in Mice Following Acute Oral Administration of Arsenate
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 468-475; doi:10.1093/toxsci/kfi107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. A. Corley, M. J. Bartels, E. W. Carney, K. K. Weitz, J. J. Soelberg, R. A. Gies, and K. D. Thrall

Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 476-490; doi:10.1093/toxsci/kfi119 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

R. A. Corley and K. E. McMartin

Incorporation of Therapeutic Interventions in Physiologically Based Pharmacokinetic Modeling of Human Clinical Case Reports of Accidental or Intentional Overdosing with Ethylene Glycol
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 491-501; doi:10.1093/toxsci/kfi120 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

CARCINOGENICITY:

Guo-fang Lin, Wei-chao Guo, Ji-gang Chen, Yi-qing Qin, Klaus Golka, Cui-qing Xiang, Qing-wen Ma, Da-ru Lu, and Jian-hua Shen

An Association of UDP-Glucuronosyltransferase 2B7 C₈₀₂T (His₂₆₈Tyr) Polymorphism with Bladder Cancer in Benzidine-Exposed Workers in China
ToxSci Advance Access published on December 22, 2004
Toxicol. Sci. 2005 85: 502-506; doi:10.1093/toxsci/kfi068 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wilfried Bursch, Ute Wastl, Karin Hufnagl, and Rolf Schulte-Hermann

No Increase of Apoptosis in Regressing Mouse Liver after Withdrawal of Growth Stimuli or Food Restriction
ToxSci Advance Access published on February 23, 2005
Toxicol. Sci. 2005 85: 507-514; doi:10.1093/toxsci/kfi128 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wilfried Bursch, Monika Chabicovsky, Ute Wastl, Bettina Grasl-Kraupp, Krystina Bukowska, Henryk Taper, and Rolf Schulte-Hermann

Apoptosis in Stages of Mouse Hepatocarcinogenesis: Failure to Counterbalance Cell Proliferation and to Account for Strain Differences in Tumor Susceptibility
ToxSci Advance Access published on February 23, 2005
Toxicol. Sci. 2005 85: 515-529; doi:10.1093/toxsci/kfi129 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Lih-Ann Li and Pei-Wen Wang

PCB126 Induces Differential Changes in Androgen, Cortisol, and Aldosterone Biosynthesis in Human Adrenocortical H295R Cells
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 530-540; doi:10.1093/toxsci/kfi105 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Pei-Chung Lee, I-Ching Ho, and Te-Chang Lee

Oxidative Stress Mediates Sodium Arsenite-Induced Expression of Heme Oxygenase-1, Monocyte Chemoattractant Protein-1, and Interleukin-6 in Vascular Smooth Muscle Cells
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 541-550; doi:10.1093/toxsci/kfi101 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Pei-Ming Yang, Shu-Jun Chiu, and Lih-Yuan Lin

Differential Effects of Salen and Manganese-Salen Complex (EUK-8) on the Regulation of Cellular Cadmium Uptake and Toxicity
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 551-559; doi:10.1093/toxsci/kfi096 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Claire R. Croutch, Margitta Lebofsky, Karl-Werner Schramm, Paul F. Terranova, and Karl K. Rozman

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and 1,2,3,4,7,8-Hexachlorodibenzo-p-Dioxin (HxCDD) Alter Body Weight by Decreasing Insulin-Like Growth Factor I (IGF-I) Signaling
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 560-571; doi:10.1093/toxsci/kfi106 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

David C. Volz, David C. Bencic, David E. Hinton, J. McHugh Law, and Seth W. Kullman

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 572-584; doi:10.1093/toxsci/kfi109 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Jeong-Ho Kim, Kiyoshi Yamaguchi, Seong-Ho Lee, Patricia K. Tithof, Gary S. Sayler, Joo-Heon Yoon, and Seung Joon Baek

Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 585-593; doi:10.1093/toxsci/kfi118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Katsuhiko Yoshizawa, Tiwanda Marsh, Julie F. Foley, Bo Cai, Shyamal Peddada, Nigel J. Walker, and Abraham Nyska

Mechanisms of Exocrine Pancreatic Toxicity Induced by Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Female Harlan Sprague-Dawley Rats
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 594-606; doi:10.1093/toxsci/kfi121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Noriko Nishimura, Junzo Yonemoto, Hisao Nishimura, Shin-ichi Ikushiro, and Chiharu Tohyama

Disruption of Thyroid Hormone Homeostasis at Weaning of Holtzman Rats by Lactational but Not In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 607-614; doi:10.1093/toxsci/kfi122 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Yankai Xia, Senping Cheng, Qian Bian, Lichun Xu, Michael D. Collins, Hebron C. Chang, Lin Song, Jiayin Liu, Shoulin Wang, and Xinru Wang

Genotoxic Effects on Spermatozoa of Carbaryl-Exposed Workers
ToxSci Advance Access published on December 22, 2004
Toxicol. Sci. 2005 85: 615-623; doi:10.1093/toxsci/kfi066 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Sherif Z. Abdel-Rahman, Marinel M. Ammenheuser, Curtis J. Omiecinski, Jeffrey K. Wickliffe, Judah I. Rosenblatt, and Jonathan B. Ward, Jr.

Variability in Human Sensitivity to 1,3-Butadiene: Influence of Polymorphisms in the 5'-Flanking Region of the Microsomal Epoxide Hydrolase Gene (EPHX1)
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 624-631; doi:10.1093/toxsci/kfi115 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING:

Marja van de Bovenkamp, Geny M. M. Groothuis, Annelies L. Draaisma, Marjolijn T. Merema, Judith I. Bezuijen, Marit J. van Gils, Dirk K. F. Meijer, Scott L. Friedman, and Peter Olinga

Precision-Cut Liver Slices as a New Model to Study Toxicity-Induced Hepatic Stellate Cell Activation in a Physiologic Milieu
ToxSci Advance Access published on February 23, 2005
Toxicol. Sci. 2005 85: 632-638; doi:10.1093/toxsci/kfi127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

M. B. Moretto, C. Funchal, G. Zeni, R. Pessoa-Pureur, and J. B. T. Rocha

Selenium Compounds Prevent the Effects of Methylmercury on the in Vitro Phosphorylation of Cytoskeletal Proteins in Cerebral Cortex of Young Rats
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 639-646; doi:10.1093/toxsci/kfi114 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. Sui, W. L. Anderson, and M. E. Gilbert

Impairment in Short-Term but Enhanced Long-Term Synaptic Potentiation and ERK Activation in Adult Hippocampal Area CA1 Following Developmental Thyroid Hormone Insufficiency^*
ToxSci Advance Access published on January 26, 2005
Toxicol. Sci. 2005 85: 647-656; doi:10.1093/toxsci/kfi095 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Valeria Ghiaroni, Makoto Sasaki, Haruhiko Fuwa, Gian Paolo Rossini, Giuseppe Scalera, Takeshi Yasumoto, Pierangelo Pietra, and Albertino Bigiani

Inhibition of Voltage-Gated Potassium Currents by Gambierol in Mouse Taste Cells
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 657-665; doi:10.1093/toxsci/kfi097 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hwei-Hsien Chen, Chao-Ting Wei, Yi-Ruu Lin, Te-Hsiung Chien, and Ming-Huan Chan

Neonatal Toluene Exposure Alters Agonist and Antagonist Sensitivity and NR2B Subunit Expression of NMDA Receptors in Cultured Cerebellar Granule Neurons
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 666-674; doi:10.1093/toxsci/kfi100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Tamio Fukushima, Masashi Kato, Tetsuya Adachi, Yoshimasa Hamada, Masao Horimoto, Masatoshi Komiyama, Chisato Mori, and Ikuo Horii

Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats
ToxSci Advance Access published on December 29, 2004
Toxicol. Sci. 2005 85: 675-682; doi:10.1093/toxsci/kfi071 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Heather M. Handley-Goldstone, Matthew W. Grow, and John J. Stegeman

Cardiovascular Gene Expression Profiles of Dioxin Exposure in Zebrafish Embryos
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 683-693; doi:10.1093/toxsci/kfi116 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Rita Loch-Caruso, Brad L. Upham, Craig Harris, and James E. Trosko

Divergent Roles for Glutathione in Lindane-Induced Acute and Delayed-Onset Inhibition of Rat Myometrial Gap Junctions
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 694-702; doi:10.1093/toxsci/kfi123 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Majorie B. M. van Duursen, J. Thomas Sanderson, and Martin van den Berg

Cytochrome P450 1A1 and 1B1 in Human Blood Lymphocytes Are Not Suitable as Biomarkers of Exposure to Dioxin-like Compounds: Polymorphisms and Interindividual Variation in Expression and Inducibility
ToxSci Advance Access published on January 19, 2005
Toxicol. Sci. 2005 85: 703-712; doi:10.1093/toxsci/kfi089 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Brian J. Day and Chirag Kariya

A Novel Class of Cytochrome P450 Reductase Redox Cyclers: Cationic Manganoporphyrins
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 85: 713-719; doi:10.1093/toxsci/kfi108 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jin Seok Kang, Hideki Wanibuchi, Keiichirou Morimura, Rawiwan Puatanachokchai, Elsayed I. Salim, Atsushi Hagihara, Shuichi Seki, and Shoji Fukushima

Enhancement by Estradiol 3-Benzoate in Thioacetamide-Induced Liver Cirrhosis of Rats
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 720-726; doi:10.1093/toxsci/kfi113 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Yan-Mei Yang, Dong-Yang Huang, Ge-Fei Liu, Jiu-Chang Zhong, Kun Du, Yi-Fan Li, and Xu-Hong Song

Inhibitory Effects of Vitamin A on TCDD-induced Cytochrome P-450 1A1 Enzyme Activity and Expression
ToxSci Advance Access published on February 23, 2005
Toxicol. Sci. 2005 85: 727-734; doi:10.1093/toxsci/kfi130 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gerald Schwerdt, Ruth Freudinger, Claudia Schuster, Florian Weber, Oliver Thews, and Michael Gekle

Cisplatin-Induced Apoptosis Is Enhanced by Hypoxia and by Inhibition of Mitochondria in Renal Collecting Duct Cells
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 85: 735-742; doi:10.1093/toxsci/kfi117 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

LETTERS TO THE EDITOR:

Giuseppe Latini, Marika Massaro, and Claudio De Felice

Prenatal Exposure to Phthalates and Intrauterine Inflammation: A Unifying Hypothesis
ToxSci Advance Access published on February 23, 2005
Toxicol. Sci. 2005 85: 743; doi:10.1093/toxsci/kfi131 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.