Toxicological Sciences

ARTICLES:

Toxicological Sciences Public Access Policy
Toxicol. Sci. 2005 85: 745; doi:10.1093/toxsci/kfi182 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENIC POTENCY DATABASE:

Lois Swirsky Gold, Neela B. Manley, Thomas H. Slone, Lars Rohrbach, and Georganne Backman Garfinkel

Supplement to the Carcinogenic Potency Database (CPDB): Results of Animal Bioassays Published in the General Literature through 1997 and by the National Toxicology Program in 1997–1998
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 85: 747-808; doi:10.1093/toxsci/kfi161 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

REVIEWS:

Donald G. Robertson

Metabonomics in Toxicology: A Review
ToxSci Advance Access published on February 2, 2005
Toxicol. Sci. 2005 85: 809-822; doi:10.1093/toxsci/kfi102 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Justin G. Teeguarden, John M. Waechter, Jr., Harvey J. Clewell, III, Tammie R. Covington, and Hugh A. Barton

Evaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 823-838; doi:10.1093/toxsci/kfi135 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Faisal F. Y. Radwan, Zhihong Wang, and John S. Ramsdell

Identification of a Rapid Detoxification Mechanism for Brevetoxin in Rats
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 839-846; doi:10.1093/toxsci/kfi138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Balázs Németi and Zoltán Gregus

Reduction of Arsenate to Arsenite by Human Erythrocyte Lysate and Rat Liver Cytosol – Characterization of a Glutathione- and NAD-Dependent Arsenate Reduction Linked to Glycolysis
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 847-858; doi:10.1093/toxsci/kfi157 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Zoltán Gregus and Balázs Németi

The Glycolytic Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Works as an Arsenate Reductase in Human Red Blood Cells and Rat Liver Cytosol
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 859-869; doi:10.1093/toxsci/kfi158 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Beatriz Montaner, Wilmar Castillo-Ávila, Marc Martinell, Rupert Öllinger, Joan Aymami, Ernest Giralt, and Ricardo Pérez-Tomás

DNA Interaction and Dual Topoisomerase I and II Inhibition Properties of the Anti-Tumor Drug Prodigiosin
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 870-879; doi:10.1093/toxsci/kfi149 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Michelle Pine, Boyeon Lee, Robert Dearth, Jill K. Hiney, and W. Les Dees

Manganese Acts Centrally to Stimulate Luteinizing Hormone Secretion: A Potential Influence on Female Pubertal Development
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 880-885; doi:10.1093/toxsci/kfi134 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anne Marie Vinggaard, Sofie Christiansen, Peter Laier, Mette Erecius Poulsen, Vibeke Breinholt, Kirsten Jarfelt, Helene Jacobsen, Majken Dalgaard, Christine Nellemann, and Ulla Hass

Perinatal Exposure to the Fungicide Prochloraz Feminizes the Male Rat Offspring
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 886-897; doi:10.1093/toxsci/kfi150 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Dolores Helena Rodriguez Ferreira Rivero, Sandra Regina Castro Soares, Geraldo Lorenzi-Filho, Mitiko Saiki, John J. Godleski, Leila Antonangelo, Marisa Dolhnikoff, and Paulo Hilário Nascimento Saldiva

Acute Cardiopulmonary Alterations Induced by Fine Particulate Matter of São Paulo, Brazil
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 898-905; doi:10.1093/toxsci/kfi137 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Volkan Gurel, Donald A. Sens, Seema Somji, Scott H. Garrett, Tim Weiland, and Mary Ann Sens

Post-Transcriptional Regulation of Metallothionein Isoform 1 and 2 Expression in the Human Breast and the MCF-10A Cell Line
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 906-915; doi:10.1093/toxsci/kfi155 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Hui-Ren Zhou, Qunshan Jia, and James J. Pestka

Ribotoxic Stress Response to the Trichothecene Deoxynivalenol in the Macrophage Involves the Src Family Kinase Hck
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 916-926; doi:10.1093/toxsci/kfi146 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Dora Farkas and Steven R. Tannenbaum

Characterization of Chemically Induced Hepatotoxicity in Collagen Sandwiches of Rat Hepatocytes
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 927-934; doi:10.1093/toxsci/kfi145 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Mattias Öberg, Linda Bergander, Helen Håkansson, Ulf Rannug, and Agneta Rannug

Identification of the Tryptophan Photoproduct 6-Formylindolo[3,2-b]carbazole, in Cell Culture Medium, as a Factor That Controls the Background Aryl Hydrocarbon Receptor Activity
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 935-943; doi:10.1093/toxsci/kfi154 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

NEUROTOXICOLOGY:

Fernando Cañadas, Diana Cardona, Eva Dávila, and Fernando Sánchez-Santed

Long-Term Neurotoxicity of Chlorpyrifos: Spatial Learning Impairment on Repeated Acquisition in a Water Maze
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 944-951; doi:10.1093/toxsci/kfi143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Prasada Rao S. Kodavanti and Thomas R. Ward

Differential Effects of Commercial Polybrominated Diphenyl Ether and Polychlorinated Biphenyl Mixtures on Intracellular Signaling in Rat Brain in Vitro
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 952-962; doi:10.1093/toxsci/kfi147 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert E. Lasky, Melissa L. Luck, Nehal A. Parikh, and Nellie K. Laughlin

The Effects of Early Lead Exposure on the Brains of Adult Rhesus Monkeys: A Volumetric MRI Study
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 963-975; doi:10.1093/toxsci/kfi153 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Alain Mirza, Véronique Eder, Gaël Y Rochefort, Jean-Marc Hyvelin, Marie Christine Machet, Laurent Fauchier, and Pierre Bonnet

CO Inhalation at Dose Corresponding to Tobacco Smoke Worsens Cardiac Remodeling after Experimental Myocardial Infarction in Rats
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 976-982; doi:10.1093/toxsci/kfi139 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vanessa M Silva, Nancy Corson, Alison Elder, and Günter Oberdörster

The Rat Ear Vein Model for Investigating In Vivo Thrombogenicity of Ultrafine Particles (UFP)
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 983-989; doi:10.1093/toxsci/kfi142 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ilona Jaspers, Jonathan M. Ciencewicki, Wenli Zhang, Luisa E. Brighton, Johnny L. Carson, Melinda A. Beck, and Michael C. Madden

Diesel Exhaust Enhances Influenza Virus Infections in Respiratory Epithelial Cells
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 990-1002; doi:10.1093/toxsci/kfi141 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Hanna M. Miettinen, Pasi Pulkkinen, Timo Jämsä, Jaana Koistinen, Ulla Simanainen, Jouko Tuomisto, Juha Tuukkanen, and Matti Viluksela

Effects of In Utero and Lactational TCDD Exposure on Bone Development in Differentially Sensitive Rat Lines
ToxSci Advance Access published on March 2, 2005
Toxicol. Sci. 2005 85: 1003-1012; doi:10.1093/toxsci/kfi136 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jin Yan and Barbara F. Hales

Activator Protein-1 (AP-1) DNA Binding Activity Is Induced by Hydroxyurea in Organogenesis Stage Mouse Embryos
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 1013-1023; doi:10.1093/toxsci/kfi148 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Paul M. D. Foster and Martha W. Harris

Changes in Androgen-Mediated Reproductive Development in Male Rat Offspring Following Exposure to a Single Oral Dose of Flutamide at Different Gestational Ages
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 1024-1032; doi:10.1093/toxsci/kfi159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Bas G. H. Bokkers and Wout Slob

A Comparison of Ratio Distributions Based on the NOAEL and the Benchmark Approach for Subchronic-to-Chronic Extrapolation
ToxSci Advance Access published on March 16, 2005
Toxicol. Sci. 2005 85: 1033-1040; doi:10.1093/toxsci/kfi144 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Paul A. Dabisch, Dennis B. Miller, Sharon A. Reutter, Robert J. Mioduszewski, and Sandra A. Thomson

Miotic Tolerance to Sarin Vapor Exposure: Role of the Sympathetic and Parasympathetic Nervous Systems
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 1041-1047; doi:10.1093/toxsci/kfi151 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Darrell R. Boverhof, Lyle D. Burgoon, Colleen Tashiro, Brock Chittim, Jack R. Harkema, Donald B. Jump, and Timothy R. Zacharewski

Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 85: 1048-1063; doi:10.1093/toxsci/kfi162 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

LETTERS TO THE EDITOR:

William J. Waddell

TO THE EDITOR
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 85: 1064-1065; doi:10.1093/toxsci/kfi152 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

ERRATA:

Cardiovascular Gene Expression Profiles of Dioxin Exposure in Zebrafish Embryos
Toxicol. Sci. 2005 85: 1066; doi:10.1093/toxsci/kfi181 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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