Toxicological Sciences

EDITORIALS:

Vicki L. Dellarco and Karl Baetcke

A Risk Assessment Perspective: Application of Mode of Action and Human Relevance Frameworks to the Analysis of Rodent Tumor Data
Toxicol. Sci. 2005 86: 1-3; doi:10.1093/toxsci/kfi133 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT:

Olga Genbacev-Krtolica

Highlight for Phenols, Quinolines, Indoles, Benzene and 2-Cyclopenten-1-ones Are Oviduct Toxicants in Cigarette Smoke, by Prue Talbot, Karen Riveles, and Ryan Rosa: List of Tobacco-Smoke Constituents That Are Harmful for Reproduction Grows—Passive Smokers May Be at Risk
Toxicol. Sci. 2005 86: 4-5; doi:10.1093/toxsci/kfi193 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEWS:

Adrian J. Hill, Hiroki Teraoka, Warren Heideman, and Richard E. Peterson

Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
ToxSci Advance Access published on February 9, 2005
Toxicol. Sci. 2005 86: 6-19; doi:10.1093/toxsci/kfi110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

J. L. C. M. Dorne and A. G. Renwick

The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 86: 20-26; doi:10.1093/toxsci/kfi160 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Nadine Knoll, Carola Ruhe, Selvaraju Veeriah, Julia Sauer, Michael Glei, Evan P. Gallagher, and Beatrice L. Pool-Zobel

Genotoxicity of 4-Hydroxy-2-Nonenal in Human Colon Tumor Cells Is Associated with Cellular Levels of Glutathione and the Modulation of Glutathione S-Transferase A4 Expression by Butyrate
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 27-35; doi:10.1093/toxsci/kfi171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Trevor Green, Alison Toghill, Robert Lee, Felix Waechter, Edgar Weber, and James Noakes

Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans: Part 1: Mode of Action Studies in the Mouse
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 86: 36-47; doi:10.1093/toxsci/kfi124 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Trevor Green, Alison Toghill, Robert Lee, Felix Waechter, Edgar Weber, Richard Peffer, James Noakes, and Mervyn Robinson

Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans: Part 2: Species Differences in Response
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 86: 48-55; doi:10.1093/toxsci/kfi125 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Timothy Pastoor, Patrick Rose, Sara Lloyd, Richard Peffer, and Trevor Green

Case Study: Weight of Evidence Evaluation of the Human Health Relevance of Thiamethoxam-Related Mouse Liver Tumors
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 86: 56-60; doi:10.1093/toxsci/kfi126 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. Hasumura, T. Imai, T. Takizawa, M. Ueda, J. Onose, and M. Hirose

Promotion of Thyroid Carcinogenesis by para-aminobenzoic Acid in Rats Initiated with N-bis(2-hydroxypropyl)nitrosamine
ToxSci Advance Access published on April 20, 2005
Toxicol. Sci. 2005 86: 61-67; doi:10.1093/toxsci/kfi173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Jun Gao, Fredine T. Lauer, Sandy Dunaway, and Scott W. Burchiel

Cytochrome P450 1B1 Is Required for 7,12-Dimethylbenz(a)-anthracene (DMBA) Induced Spleen Cell Immunotoxicity
ToxSci Advance Access published on April 20, 2005
Toxicol. Sci. 2005 86: 68-74; doi:10.1093/toxsci/kfi176 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nasr Y. A. Hemdan, Frank Emmrich, Khadiga Adham, Gunnar Wichmann, Irina Lehmann, Azza El-Massry, Hossam Ghoneim, Jörg Lehmann, and Ulrich Sack

Dose-Dependent Modulation of the In Vitro Cytokine Production of Human Immune Competent Cells by Lead Salts
ToxSci Advance Access published on April 20, 2005
Toxicol. Sci. 2005 86: 75-83; doi:10.1093/toxsci/kfi177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wanda R. Fields, Randi M. Leonard, Pamela S. Odom, Brian K. Nordskog, Michael W. Ogden, and David J. Doolittle

Gene Expression in Normal Human Bronchial Epithelial (NHBE) Cells Following In Vitro Exposure to Cigarette Smoke Condensate
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 84-91; doi:10.1093/toxsci/kfi179 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Mi Young Yang, Serrine S. Lau, and Terrence J. Monks

2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ)-Mediated Apoptosis of Human Promyelocytic Leukemia Cells Is Preceded by Mitochondrial Cytochrome c Release in the Absence of a Decrease in the Mitochondrial Membrane Potential
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 86: 92-100; doi:10.1093/toxsci/kfi165 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

V. C. Moser, M. Casey, A. Hamm, W. H. Carter, Jr., J. E. Simmons, and C. Gennings

Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray Design
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 86: 101-115; doi:10.1093/toxsci/kfi163 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

L. Li, K. Prabhakaran, E. M. Mills, J. L. Borowitz, and G. E. Isom

Enhancement of Cyanide-Induced Mitochondrial Dysfunction and Cortical Cell Necrosis by Uncoupling Protein-2
ToxSci Advance Access published on March 30, 2005
Toxicol. Sci. 2005 86: 116-124; doi:10.1093/toxsci/kfi164 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard F. Seegal, Karl O. Brosch, and Richard J. Okoniewski

Coplanar PCB Congeners Increase Uterine Weight and Frontal Cortical Dopamine in the Developing Rat: Implications for Developmental Neurotoxicity
ToxSci Advance Access published on April 20, 2005
Toxicol. Sci. 2005 86: 125-131; doi:10.1093/toxsci/kfi174 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Damani K. Parran, Angela Barker, and Marion Ehrich

Effects of Thimerosal on NGF Signal Transduction and Cell Death in Neuroblastoma Cells
ToxSci Advance Access published on April 20, 2005
Toxicol. Sci. 2005 86: 132-140; doi:10.1093/toxsci/kfi175 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Karen Riveles, R. Roza, and P. Talbot

Phenols, Quinolines, Indoles, Benzene, and 2-Cyclopenten-1-ones are Oviductal Toxicants in Cigarette Smoke
ToxSci Advance Access published on February 16, 2005
Toxicol. Sci. 2005 86: 141-151; doi:10.1093/toxsci/kfi112 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kelly W. Wilhelms, Sara A. Cutler, John A. Proudman, Lloyd L. Anderson, and Colin G. Scanes

Atrazine and the Hypothalamo-Pituitary-Gonadal Axis in Sexually Maturing Precocial Birds: Studies in Male Japanese Quail
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 152-160; doi:10.1093/toxsci/kfi170 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christopher J. Bowman, Katie J. Turner, Madhabananda Sar, Norman J. Barlow, Kevin W. Gaido, and Paul M. D. Foster

Altered Gene Expression During Rat Wolffian Duct Development following Di(n-Butyl) Phthalate Exposure
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 161-174; doi:10.1093/toxsci/kfi172 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. Desaulniers, G.-H. Xiao, K. Leingartner, I. Chu, B. Musicki, and B. K. Tsang

Comparisons of Brain, Uterus, and Liver mRNA Expression for Cytochrome P450s, DNA Methyltransferase-1, and Catechol-O-Methyltransferase in Prepubertal Female Sprague-Dawley Rats Exposed to a Mixture of Aryl Hydrocarbon Receptor Agonists
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 175-184; doi:10.1093/toxsci/kfi178 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Gary A. Boorman, Pamela E. Blackshear, Joel S. Parker, Edward K. Lobenhofer, David E. Malarkey, Molly K. Vallant, Diane K. Gerken, and Richard D. Irwin

Hepatic Gene Expression Changes throughout the Day in the Fischer Rat: Implications for Toxicogenomic Experiments
ToxSci Advance Access published on April 6, 2005
Toxicol. Sci. 2005 86: 185-193; doi:10.1093/toxsci/kfi166 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Shih-Hsuan Hsiao, Peter D. Constable, Geoffrey W. Smith, and Wanda M. Haschek

Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulmonary Arterial Rings
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 194-199; doi:10.1093/toxsci/kfi167 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Danitsja M. van Leeuwen, Ralph W. H. Gottschalk, Marcel H. van Herwijnen, Edwin J. Moonen, Jos C. S. Kleinjans, and Joost H. M. van Delft

Differential Gene Expression in Human Peripheral Blood Mononuclear Cells Induced by Cigarette Smoke and Its Constituents
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 200-210; doi:10.1093/toxsci/kfi168 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

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