Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Nina G. Pabello and Valerie J. Bolivar

Young Brains on Lead: Adult Neurological Consequences?
Toxicol. Sci. 2005 86: 211-213; doi:10.1093/toxsci/kfi221 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEWS:

Richard M. LoPachin and Anthony P. DeCaprio

Protein Adduct Formation as a Molecular Mechanism in Neurotoxicity
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 214-225; doi:10.1093/toxsci/kfi197 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

R. Kroes, J. Kleiner, and A. Renwick

The Threshold of Toxicological Concern Concept in Risk Assessment
ToxSci Advance Access published on April 13, 2005
Toxicol. Sci. 2005 86: 226-230; doi:10.1093/toxsci/kfi169 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Naomi Kudo, Yuko Iwase, Hiroshi Okayachi, Yoshihiro Yamakawa, and Yoichi Kawashima

Induction of Hepatic Peroxisome Proliferation by 8–2 Telomer Alcohol Feeding In Mice: Formation of Perfluorooctanoic Acid in the Liver
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 231-238; doi:10.1093/toxsci/kfi191 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. L. Mendrala, D. A. Markham, and D. L. Eisenbrandt

Rapid Uptake, Metabolism, and Elimination of Inhaled Sulfuryl Fluoride Fumigant by Rats
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 239-247; doi:10.1093/toxsci/kfi196 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Chandrashekhar D. Kamat, Dixy E. Green, Susan Curilla, Linda Warnke, Joshua W. Hamilton, Stefan Sturup, Callie Clark, and Michael A. Ihnat

Role of HIF Signaling on Tumorigenesis in Response to Chronic Low-Dose Arsenic Administration
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 248-257; doi:10.1093/toxsci/kfi190 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Akiyoshi Nishikawa, Takako Ikeda, Hwa-Young Son, Kazushi Okazaki, Takayoshi Imazawa, Takashi Umemura, Shuichi Kimura, and Masao Hirose

Pronounced Synergistic Promotion of N-Bis(2-hydroxypropyl)Nitrosamine-Initiated Thyroid Tumorigenesis in Rats Treated with Excess Soybean and Iodine-Deficient Diets
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 258-263; doi:10.1093/toxsci/kfi206 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Nick Fletcher, Norbert Giese, Carsten Schmidt, Natalia Stern, P. Monica Lind, Matti Viluksela, Jouni T. Tuomisto, Jouko Tuomisto, Heinz Nau, and Helen Håkansson

Altered Retinoid Metabolism in Female Long-Evans and Han/Wistar Rats following Long-Term 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Treatment
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 264-272; doi:10.1093/toxsci/kfi183 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Markus Hecker, June-Woo Park, Margaret B. Murphy, Paul D. Jones, Keith R. Solomon, Glen Van Der Kraak, James A. Carr, Ernest E. Smith, Louis du Preez, Ronald J. Kendall, and John P. Giesy

Effects of Atrazine on CYP19 Gene Expression and Aromatase Activity in Testes and on Plasma Sex Steroid Concentrations of Male African Clawed Frogs (Xenopus laevis)
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 273-280; doi:10.1093/toxsci/kfi203 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael E. Wyde, Shaun E. Kirwan, Fan Zhang, Ashley Laughter, Holly B. Hoffman, Erika Bartolucci-Page, Kevin W. Gaido, Bingfang Yan, and Li You

Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 281-290; doi:10.1093/toxsci/kfi204 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Gary B. Quistad, Rebecka Klintenberg, and John E. Casida

Blood Acylpeptide Hydrolase Activity Is a Sensitive Marker for Exposure to Some Organophosphate Toxicants
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 291-299; doi:10.1093/toxsci/kfi195 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gerald T. Ankley, Kathleen M. Jensen, Elizabeth J. Durhan, Elizabeth A. Makynen, Brian C. Butterworth, Michael D. Kahl, Daniel L. Villeneuve, Ann Linnum, L. Earl Gray, Mary Cardon, and Vickie S. Wilson

Effects of Two Fungicides with Multiple Modes of Action on Reproductive Endocrine Function in the Fathead Minnow (Pimephales promelas)
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 300-308; doi:10.1093/toxsci/kfi202 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Norbert H. Kleinsasser, Andrea W. Sassen, Marzell P. Semmler, Ulrich A. Harréus, Anna-Katharina Licht, and Elmar Richter

The Tobacco Alkaloid Nicotine Demonstrates Genotoxicity in Human Tonsillar Tissue and Lymphocytes
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 309-317; doi:10.1093/toxsci/kfi186 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Werner K. Lutz, Oliver Tiedge, Roman W. Lutz, and Helga Stopper

Different Types of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents MMS, MNU, and Genistein
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 318-323; doi:10.1093/toxsci/kfi200 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY:

Nikolay M. Filipov, Lesya M. Pinchuk, Bobbie L. Boyd, and Patrick L. Crittenden

Immunotoxic Effects of Short-term Atrazine Exposure in Young Male C57BL/6 Mice
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 324-332; doi:10.1093/toxsci/kfi188 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

F. van Wijk, S. Nierkens, I. Hassing, M. Feijen, S. J. Koppelman, G. A. H. de Jong, R Pieters, and L. M. J. Knippels

The Effect of the Food Matrix on In Vivo Immune Responses to Purified Peanut Allergens
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 333-341; doi:10.1093/toxsci/kfi187 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

C. J. Fong, L. D. Burgoon, and T. R. Zacharewski

Comparative Microarray Analysis of Basal Gene Expression in Mouse Hepa-1c1c7 Wild-Type and Mutant Cell Lines
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 342-353; doi:10.1093/toxsci/kfi194 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Han K. Ho, Collin C. White, Carolina Fernandez, Nelson Fausto, Terrance J. Kavanagh, Sidney D. Nelson, and Sam A. Bruschi

Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 354-364; doi:10.1093/toxsci/kfi205 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

M. E. Gilbert, M. E. Kelly, T. E. Samsam, and J. H. Goodman

Chronic Developmental Lead Exposure Reduces Neurogenesis in Adult Rat Hippocampus but Does Not Impair Spatial Learning
ToxSci Advance Access published on March 23, 2005
Toxicol. Sci. 2005 86: 365-374; doi:10.1093/toxsci/kfi156 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

V. C. Moser, P. M. Phillips, K. L. McDaniel, R. S. Marshall, D. L. Hunter, and S. Padilla

Neurobehavioral Effects of Chronic Dietary and Repeated High-Level Spike Exposure to Chlorpyrifos in Rats
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 375-386; doi:10.1093/toxsci/kfi199 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Wayne A. Fritz, Tien-Min Lin, Robert W. Moore, Paul S. Cooke, and Richard E. Peterson

In Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure: Effects on the Prostate and Its Response to Castration in Senescent C57BL/6J Mice
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 387-395; doi:10.1093/toxsci/kfi189 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jorge M. Naciff, Karla A. Hess, Gary J. Overmann, Suzanne M. Torontali, Gregory J. Carr, Jay P. Tiesman, Leslie M. Foertsch, Brian D. Richardson, Joel E. Martinez, and George P. Daston

Gene Expression Changes Induced in the Testis by Transplacental Exposure to High and Low Doses of 17-Ethynyl Estradiol, Genistein, or Bisphenol A
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 396-416; doi:10.1093/toxsci/kfi198 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Rita Loch Caruso, Brad L. Upham, Craig Harris, and James E. Trosko

Biphasic Lindane-Induced Oxidation of Glutathione and Inhibition of Gap Junctions in Myometrial Cells
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 417-426; doi:10.1093/toxsci/kfi208 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Vincent Tong, Xiao Wei Teng, Thomas K. H. Chang, and Frank S. Abbott

Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 427-435; doi:10.1093/toxsci/kfi184 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vincent Tong, Xiao Wei Teng, Thomas K. H. Chang, and Frank S. Abbott

Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes
ToxSci Advance Access published on April 27, 2005
Toxicol. Sci. 2005 86: 436-443; doi:10.1093/toxsci/kfi185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nathalie Ledirac, Sebastien Antherieu, Anne Dupuy d'Uby, Jean-Claude Caron, and Roger Rahmani

Effects of Organochlorine Insecticides on MAP Kinase Pathways in Human HaCaT Keratinocytes: Key Role of Reactive Oxygen Species
ToxSci Advance Access published on May 11, 2005
Toxicol. Sci. 2005 86: 444-452; doi:10.1093/toxsci/kfi192 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, and George Orphanides

Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 86: 453-469; doi:10.1093/toxsci/kfi207 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

J. M. Gohlke, W. C. Griffith, and E. M. Faustman

A Systems-Based Computational Model for Dose-Response Comparisons of Two Mode of Action Hypotheses for Ethanol-Induced Neurodevelopmental Toxicity
ToxSci Advance Access published on May 25, 2005
Toxicol. Sci. 2005 86: 470-484; doi:10.1093/toxsci/kfi209 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

ERRATA:

Spatial Alternation Deficits Following Developmental Exposure to Aroclor 1254 and/or Methylmercury in Rats
Toxicol. Sci. 2005 86: 485; doi:10.1093/toxsci/kfi232 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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