Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Elaine Holmes and Jeremy Nicholson

Variation in Gut Microbiota Strongly Influences Individual Rodent Phenotypes
Toxicol. Sci. 2005 87: 1-2; doi:10.1093/toxsci/kfi259 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Lesa L. Aylward, James C. Lamb, and Steven C. Lewis

Issues in Risk Assessment for Developmental Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Compounds
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 3-10; doi:10.1093/toxsci/kfi236 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM:

Jacques P. Maurissen, Steven G. Gilbert, Miriam Sander, Tom L. Beauchamp, Shelley Johnson, Bernard A. Schwetz, Merrill Goozner, and Craig S. Barrow

Workshop Proceedings: Managing Conflict of Interest in Science. A Little Consensus and A Lot of Controversy
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 11-14; doi:10.1093/toxsci/kfi240 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Yuzhao Zhou and Robert A. Yokel

The Chemical Species of Aluminum Influences Its Paracellular Flux across and Uptake into Caco-2 Cells, a Model of Gastrointestinal Absorption
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 15-26; doi:10.1093/toxsci/kfi216 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel E. W. Machemer and Robert H. Tukey

The Role of Protein Kinase C in Regulation of TCDD-Mediated CYP1A1 Gene Expression
ToxSci Advance Access published on June 9, 2005
Toxicol. Sci. 2005 87: 27-37; doi:10.1093/toxsci/kfi220 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

De-Xiang Xu, Yuan-Hua Chen, Jian-Ping Wang, Mei-Fang Sun, Hua Wang, Ling-Zhen Wei, and Wei Wei

Perinatal Lipopolysaccharide Exposure Downregulates Pregnane X Receptor and Cyp3a11 Expression in Fetal Mouse Liver
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 38-45; doi:10.1093/toxsci/kfi239 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

E. Dopp, L. M. Hartmann, U. von Recklinghausen, A. M. Florea, S. Rabieh, U. Zimmermann, B. Shokouhi, S. Yadav, A. V. Hirner, and A. W. Rettenmeier

Forced Uptake of Trivalent and Pentavalent Methylated and Inorganic Arsenic and Its Cyto-/genotoxicity in Fibroblasts and Hepatoma Cells
ToxSci Advance Access published on June 9, 2005
Toxicol. Sci. 2005 87: 46-56; doi:10.1093/toxsci/kfi218 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Trine Reistad and Espen Mariussen

A Commercial Mixture of the Brominated Flame Retardant Pentabrominated Diphenyl Ether (DE-71) Induces Respiratory Burst in Human Neutrophil Granulocytes In Vitro
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 57-65; doi:10.1093/toxsci/kfi222 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Scott H. Garrett, Seongmi Park, Mary Ann Sens, Seema Somji, Rajendra K. Singh, Venugopal B. R. K. Namburi, and Donald A. Sens

Expression of Metallothoinein Isoform 3 Is Restricted at the Post-Transcriptional Level in Human Bladder Epithelial Cells
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 66-74; doi:10.1093/toxsci/kfi231 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Stephen B. Pruett, Qiang Zheng, Carlton Schwab, and Ruping Fan

Sodium Methyldithiocarbamate Inhibits MAP Kinase Activation through Toll-like Receptor 4, Alters Cytokine Production by Mouse Peritoneal Macrophages, and Suppresses Innate Immunity
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 75-85; doi:10.1093/toxsci/kfi215 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Robert L. Rubin, Tracee M. Hermanson, Edward J. Bedrick, Jacob D. McDonald, Scott W. Burchiel, Mathew D. Reed, and Wilmer L. Sibbitt, Jr.

Effect of Cigarette Smoke on Autoimmunity in Murine and Human Systemic Lupus Erythematosus
ToxSci Advance Access published on June 9, 2005
Toxicol. Sci. 2005 87: 86-96; doi:10.1093/toxsci/kfi217 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vimal Selvaraj, David Bunick, Carrol Finnigan-Bunick, Rodney W. Johnson, Huixia Wang, Lei Liu, and Paul S. Cooke

Gene Expression Profiling of 17ß-Estradiol and Genistein Effects on Mouse Thymus
ToxSci Advance Access published on June 9, 2005
Toxicol. Sci. 2005 87: 97-112; doi:10.1093/toxsci/kfi219 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hui-Ren Zhou, Zahidul Islam, and James J. Pestka

Induction of Competing Apoptotic and Survival Signaling Pathways in the Macrophage by the Ribotoxic Trichothecene Deoxynivalenol
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 113-122; doi:10.1093/toxsci/kfi234 [Abstract] [FREE Full Text] [PDF] HTML Page - index.htslp [Request Permissions]  

Keith D. Salazar, Patricia de la Rosa, John B. Barnett, and Rosana Schafer

The Polysaccharide Antibody Response after Streptococcus pneumoniae Vaccination Is Differentially Enhanced or Suppressed by 3,4-Dichloropropionanilide and 2,4-Dichlorophenoxyacetic Acid
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 123-133; doi:10.1093/toxsci/kfi244 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Maoxiang Li, Christopher F. Cuff, and James Pestka

Modulation of Murine Host Response to Enteric Reovirus Infection by the Trichothecene Deoxynivalenol
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 134-145; doi:10.1093/toxsci/kfi225 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Seva E. Kostrubsky, Jacqueline F. Sinclair, Stephen C. Strom, Sheryl Wood, Ellen Urda, Donna Beer Stolz, Yuan H. Wen, Shaila Kulkarni, and Abdul Mutlib

Phenobarbital and Phenytoin Increased Acetaminophen Hepatotoxicity Due to Inhibition of UDP-Glucuronosyltransferases in Cultured Human Hepatocytes
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 146-155; doi:10.1093/toxsci/kfi211 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Anne Dreiem, Caitlyn C. Gertz, and Richard F. Seegal

The Effects of Methylmercury on Mitochondrial Function and Reactive Oxygen Species Formation in Rat Striatal Synaptosomes Are Age-Dependent
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 156-162; doi:10.1093/toxsci/kfi224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hadas Schori, Eyal Robenshtok, Michal Schwartz, and Ariel Hourvitz

Post-Intoxication Vaccination for Protection of Neurons against the Toxicity of Nerve Agents
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 163-168; doi:10.1093/toxsci/kfi237 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Tora Sund Morken, Ursula Sonnewald, Michael Aschner, and Tore Syversen

Effects of Methylmercury on Primary Brain Cells in Mono- and Co-culture
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 169-175; doi:10.1093/toxsci/kfi227 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rebekah J. Jakel, Jonathan T. Kern, Delinda A. Johnson, and Jeffrey A. Johnson

Induction of the Protective Antioxidant Response Element Pathway by 6-Hydroxydopamine In Vivo and In Vitro
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 176-186; doi:10.1093/toxsci/kfi241 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

William K. Boyes, Mark Bercegeay, Todd Krantz, Marina Evans, Vernon Benignus, and Jane Ellen Simmons

Momentary Brain Concentration of Trichloroethylene Predicts the Effects on Rat Visual Function
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 187-196; doi:10.1093/toxsci/kfi242 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Song Gao, Keyang Chen, Yinzhi Zhao, Celeste B. Rich, Lijun Chen, Sandy J. Li, Paul Toselli, Phillip Stone, and Wande Li

Transcriptional and Posttranscriptional Inhibition of Lysyl Oxidase Expression by Cigarette Smoke Condensate in Cultured Rat Fetal Lung Fibroblasts
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 197-203; doi:10.1093/toxsci/kfi212 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Anuj Sinha, Kathirvel Muthiah, Weiwu Jiang, Xanthi Couroucli, Roberto Barrios, and Bhagavatula Moorthy

Attenuation of Hyperoxic Lung Injury by the CYP1A Inducer ß–Naphthoflavone
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 204-212; doi:10.1093/toxsci/kfi226 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas G. Rand, S. Giles, J. Flemming, J. David Miller, and Eva Puniani

Inflammatory and Cytotoxic Responses in Mouse Lungs Exposed to Purified Toxins from Building Isolated Penicillium brevicompactum Dierckx and P. chrysogenum Thom.
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 87: 213-222; doi:10.1093/toxsci/kfi223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Paul M. Wise, Thomas M. Canty, and Charles J. Wysocki

Temporal Integration of Nasal Irritation from Ammonia at Threshold and Supra-threshold Levels
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 223-231; doi:10.1093/toxsci/kfi229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

JeanClare Seagrave, Andrew Gigliotti, Jacob D. McDonald, Steven K. Seilkop, Kevin A. Whitney, Barbara Zielinska, and Joe L. Mauderly

Composition, Toxicity, and Mutagenicity of Particulate and Semivolatile Emissions from Heavy-Duty Compressed Natural Gas-Powered Vehicles
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 232-241; doi:10.1093/toxsci/kfi230 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

H. O. Goyal, T. D. Braden, C. S. Williams, P. Dalvi, M. Mansour, and J. W. Williams

Estrogen-Induced Abnormal Accumulation of Fat Cells in the Rat Penis and Associated Loss of Fertility Depends upon Estrogen Exposure during Critical Period of Penile Development
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 242-254; doi:10.1093/toxsci/kfi233 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jennifer L. Rayner, Rolondo R. Enoch, and Suzanne E. Fenton

Adverse Effects of Prenatal Exposure to Atrazine During a Critical Period of Mammary Gland Growth
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 255-266; doi:10.1093/toxsci/kfi213 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Takeo Shimo, Naoki Ashizawa, Koji Matsumoto, Takashi Nakazawa, and Osamu Nagata

Simultaneous Treatment with Citrate Prevents Nephropathy Induced by FYX-051, a Xanthine Oxidoreductase Inhibitor, in Rats
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 267-276; doi:10.1093/toxsci/kfi210 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

HIGHLIGHTED ARTICLE:

Lora C. Robosky, Dale F. Wells, Laura A. Egnash, Matthew L. Manning, Michael D. Reily, and Donald G. Robertson

Metabonomic Identification of Two Distinct Phenotypes in Sprague-Dawley (Crl:CD(SD)) Rats
ToxSci Advance Access published on June 2, 2005
Toxicol. Sci. 2005 87: 277-284; doi:10.1093/toxsci/kfi214 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Joshua K. S. Ko and Chi-Hin Cho

The Diverse Actions of Nicotine and Different Extracted Fractions from Tobacco Smoke against Hapten-Induced Colitis in Rats
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 285-295; doi:10.1093/toxsci/kfi238 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

Keiichi Minami, Toshiro Saito, Masatoshi Narahara, Hiroyuki Tomita, Hirokazu Kato, Hisashi Sugiyama, Miki Katoh, Miki Nakajima, and Tsuyoshi Yokoi

Relationship between Hepatic Gene Expression Profiles and Hepatotoxicity in Five Typical Hepatotoxicant-Administered Rats
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 296-305; doi:10.1093/toxsci/kfi235 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

James F. Dillman, III and Christopher S. Phillips

Comparison of Non-Human Primate and Human Whole Blood Tissue Gene Expression Profiles
ToxSci Advance Access published on June 23, 2005
Toxicol. Sci. 2005 87: 306-314; doi:10.1093/toxsci/kfi243 [Abstract] [FREE Full Text] [PDF] Supplementary Data [Request Permissions]  

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