Toxicological Sciences

EDITORIALS:

Michael P. Holsapple and Lois D. Lehman-McKeeman

Forum Series: Research Strategies for Safety Evaluation of Nanomaterials
Toxicol. Sci. 2005 87: 315; doi:10.1093/toxsci/kfi286 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Karluss Thomas and Philip Sayre

Research Strategies for Safety Evaluation of Nanomaterials, Part I: Evaluating the Human Health Implications of Exposure to Nanoscale Materials
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 316-321; doi:10.1093/toxsci/kfi270 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Samuel M. Cohen

Effects of PPAR and Combined Agonists on the Urinary Tract of Rats and Other Species
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 322-327; doi:10.1093/toxsci/kfi266 [Extract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Lisa M. Kamendulis and James E. Klaunig

Species Differences in the Induction of Hepatocellular DNA Synthesis by Diethanolamine
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 328-336; doi:10.1093/toxsci/kfi252 [Abstract] [Full Text] [PDF] [Request Permissions]  

Louis W. Chang, Wai-Sze Lo, and Pinpin Lin

Trans, Trans-2,4-Decadienal, a Product Found in Cooking Oil Fumes, Induces Cell Proliferation and Cytokine Production Due to Reactive Oxygen Species in Human Bronchial Epithelial Cells
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 337-343; doi:10.1093/toxsci/kfi258 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lianhui Tao, Wei Wang, Long Li, Paula K. Kramer, and Michael A. Pereira

DNA Hypomethylation Induced by Drinking Water Disinfection By-Products in Mouse and Rat Kidney
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 344-352; doi:10.1093/toxsci/kfi257 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Sigmund J. Degitz, Gary W. Holcombe, Kevin M. Flynn, Patricia A. Kosian, Joseph J. Korte, and Joseph E. Tietge

Progress towards Development of an Amphibian-Based Thyroid Screening Assay Using Xenopus laevis. Organismal and Thyroidal Responses to the Model Compounds 6-Propylthiouracil, Methimazole, and Thyroxine
ToxSci Advance Access published on July 7, 2005
Toxicol. Sci. 2005 87: 353-364; doi:10.1093/toxsci/kfi246 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Simone Kann, Cameron Estes, John F. Reichard, Ming-ya Huang, Maureen A. Sartor, Sandy Schwemberger, Ying Chen, Timothy P. Dalton, Howard G. Shertzer, Ying Xia, and Alvaro Puga

Butylhydroquinone Protects Cells Genetically Deficient in Glutathione Biosynthesis from Arsenite-Induced Apoptosis Without Significantly Changing Their Prooxidant Status
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 365-384; doi:10.1093/toxsci/kfi253 [Abstract] [Full Text] [PDF] [Request Permissions]  

N. Allon, I. Rabinovitz, E. Manistersky, B. A. Weissman, and E. Grauer

Acute and Long-Lasting Cardiac Changes Following a Single Whole-Body Exposure to Sarin Vapor in Rats
ToxSci Advance Access published on July 20, 2005
Toxicol. Sci. 2005 87: 385-390; doi:10.1093/toxsci/kfi263 [Abstract] [Full Text] [PDF] [Request Permissions]  

Lingtian Xie, Kelly Thrippleton, Mary Ann Irwin, Geoffrey S. Siemering, Abdou Mekebri, David Crane, Kevin Berry, and Daniel Schlenk

Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using an Rainbow Trout Vitellogenin Assay
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 391-398; doi:10.1093/toxsci/kfi249 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Tai L. Guo, W. Auttachoat, and Rui P. Chi

Genistein Enhancement of Respiratory Allergen Trimellitic Anhydride-induced IgE Production by Adult B6C3F1 Mice Following In Utero and Postnatal Exposure
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 399-408; doi:10.1093/toxsci/kfi268 [Abstract] [Full Text] [PDF] [Request Permissions]  

Colin de Haar, Ine Hassing, Marianne Bol, Rob Bleumink, and Raymond Pieters

Ultrafine Carbon Black Particles Cause Early Airway Inflammation and Have Adjuvant Activity in a Mouse Allergic Airway Disease Model
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 409-418; doi:10.1093/toxsci/kfi255 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jun Gao, Andrew A. Voss, Isaac N. Pessah, Fredine T. Lauer, Trevor M. Penning, and Scott W. Burchiel

Ryanodine Receptor-Mediated Rapid Increase in Intracellular Calcium Induced by 7,8-Benzo(a)Pyrene Quinone in Human and Murine Leukocytes
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 419-426; doi:10.1093/toxsci/kfi265 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Ivan N. Rich and Karen M. Hall

Validation and Development of a Predictive Paradigm for Hemotoxicology Using a Multifunctional Bioluminescence Colony-Forming Proliferation Assay
ToxSci Advance Access published on July 7, 2005
Toxicol. Sci. 2005 87: 427-441; doi:10.1093/toxsci/kfi250 [Abstract] [Full Text] [PDF] [Request Permissions]  

Khalid Amin, Carmen Ip, Lucita Jimenez, Charles Tyson, and Holger Behrsing

In Vitro Detection of Differential and Cell-Specific Hepatobiliary Toxicity Induced by Geldanamycin and 17-Allylaminogeldanamycin Using Dog Liver Slices
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 87: 442-450; doi:10.1093/toxsci/kfi254 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

NEUROTOXICOLOGY:

Sherry A. Ferguson, F. Javier Cisneros, B. Gough, Joseph P. Hanig, and Kimberly J. Berry

Chronic Oral Treatment with 13-cis-Retinoic Acid (Isotretinoin) or all-trans-Retinoic Acid Does Not Alter Depression-Like Behaviors in Rats
ToxSci Advance Access published on July 20, 2005
Toxicol. Sci. 2005 87: 451-459; doi:10.1093/toxsci/kfi262 [Abstract] [Full Text] [PDF] [Request Permissions]  

Tracey E. Samsam, Deborah L. Hunter, and Philip J. Bushnell

Effects of Chronic Dietary and Repeated Acute Exposure to Chlorpyrifos on Learning and Sustained Attention in Rats
ToxSci Advance Access published on July 20, 2005
Toxicol. Sci. 2005 87: 460-468; doi:10.1093/toxsci/kfi264 [Abstract] [Full Text] [PDF] [Request Permissions]  

Miriam B. Virgolini, Kevin Chen, Doug D. Weston, Mark R. Bauter, and Deborah A. Cory-Slechta

Interactions of Chronic Lead Exposure and Intermittent Stress: Consequences for Brain Catecholamine Systems and Associated Behaviors and HPA Axis Function
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 469-482; doi:10.1093/toxsci/kfi269 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Tzuu-Huei Ueng, Chia-Chi Hung, Min-Liang Kuo, Ping-Kun Chan, Shih-Hsiung Hu, Pan-Chyr Yang, and Louis W. Chang

Induction of Fibroblast Growth Factor-9 and Interleukin-1 Gene Expression by Motorcycle Exhaust Particulate Extracts and Benzo(a)pyrene in Human Lung Adenocarcinoma Cells
ToxSci Advance Access published on July 7, 2005
Toxicol. Sci. 2005 87: 483-496; doi:10.1093/toxsci/kfi251 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Tisha King Heiden, Reinhold J. Hutz, and Michael J. Carvan, III

Accumulation, Tissue Distribution, and Maternal Transfer of Dietary 2,3,7,8,-Tetrachlorodibenzo-p-Dioxin: Impacts on Reproductive Success of Zebrafish
ToxSci Advance Access published on May 18, 2005
Toxicol. Sci. 2005 87: 497-507; doi:10.1093/toxsci/kfi201 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Jay B. Silkworth, Aruna Koganti, Kati Illouz, Antonio Possolo, Ming Zhao, and Stephen B. Hamilton

Comparison of TCDD and PCB CYP1A Induction Sensitivities in Fresh Hepatocytes from Human Donors, Sprague-Dawley Rats, and Rhesus Monkeys and HepG2 Cells
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 508-519; doi:10.1093/toxsci/kfi261 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Cynthia V. Rider and Gerald A. LeBlanc

An Integrated Addition and Interaction Model for Assessing Toxicity of Chemical Mixtures
ToxSci Advance Access published on July 7, 2005
Toxicol. Sci. 2005 87: 520-528; doi:10.1093/toxsci/kfi247 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Jeffrey C. Bemis, Daniel A. Nazarenko, and Thomas A. Gasiewicz

Coplanar Polychlorinated Biphenyls Activate the Aryl Hydrocarbon Receptor in Developing Tissues of Two TCDD-Responsive lacZ Mouse Lines
ToxSci Advance Access published on July 20, 2005
Toxicol. Sci. 2005 87: 529-536; doi:10.1093/toxsci/kfi260 [Abstract] [Full Text] [PDF] [Request Permissions]  

Misaki Kojima, Kenji Sekikawa, Kiyomitsu Nemoto, and Masakuni Degawa

Tumor Necrosis Factor--Independent Downregulation of Hepatic Cholesterol 7-Hydroxylase Gene in Mice Treated with Lead Nitrate
ToxSci Advance Access published on July 27, 2005
Toxicol. Sci. 2005 87: 537-542; doi:10.1093/toxsci/kfi267 [Abstract] [Full Text] [PDF] [Request Permissions]  

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