Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Adria A. Elskus

The Implications of Low-Affinity AhR for TCDD Insensitivity in Frogs
Toxicol. Sci. 2005 88: 1-3; doi:10.1093/toxsci/kfi321 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Cindy A. Ryan, G. Frank Gerberick, Lucy A. Gildea, Ben C. Hulette, Catherine J. Betts, Marie Cumberbatch, Rebecca J. Dearman, and Ian Kimber

Interactions of Contact Allergens with Dendritic Cells: Opportunities and Challenges for the Development of Novel Approaches to Hazard Assessment
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 88: 4-11; doi:10.1093/toxsci/kfi245 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Michael P. Holsapple, William H. Farland, Timothy D. Landry, Nancy A. Monteiro-Riviere, Janet M. Carter, Nigel J. Walker, and Karluss V. Thomas

Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and Safety Evaluation of Nanomaterials, Current Challenges and Data Needs
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 12-17; doi:10.1093/toxsci/kfi293 [Abstract] [Full Text] [PDF] [Request Permissions]  

Abigail Jacobs

Prediction of 2-Year Carcinogenicity Study Results for Pharmaceutical Products: How Are We Doing?
ToxSci Advance Access published on July 7, 2005
Toxicol. Sci. 2005 88: 18-23; doi:10.1093/toxsci/kfi248 [Abstract] [Full Text] [PDF] [Request Permissions]  

Gregory S. Ladics, Robert E. Chapin, Kenneth L. Hastings, Michael P. Holsapple, Susan L. Makris, Larry P. Sheets, Michael R. Woolhiser, and Leigh Ann Burns-Naas

Developmental Toxicology Evaluations—Issues with Including Neurotoxicology and Immunotoxicology Assessments in Reproductive Toxicology Studies
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 24-29; doi:10.1093/toxsci/kfi299 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Lena Ernstgård, Eiji Shibata, and Gunnar Johanson

Uptake and Disposition of Inhaled Methanol Vapor in Humans
ToxSci Advance Access published on August 10, 2005
Toxicol. Sci. 2005 88: 30-38; doi:10.1093/toxsci/kfi281 [Abstract] [Full Text] [PDF] [Request Permissions]  

Hesham M. Korashy and Ayman O. S. El-Kadi

Regulatory Mechanisms Modulating the Expression of Cytochrome P450 1A1 Gene by Heavy Metals
ToxSci Advance Access published on August 10, 2005
Toxicol. Sci. 2005 88: 39-51; doi:10.1093/toxsci/kfi282 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Hyun-Jung Kim, Young In Park, and Mi-Sook Dong

Effects of 2,4-D and DCP on the DHT-Induced Androgenic Action in Human Prostate Cancer Cells
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 52-59; doi:10.1093/toxsci/kfi287 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Jeremy A. Lavine, Ashley J. Rowatt, Tatyana Klimova, Aric J. Whitington, Emelyne Dengler, Catherine Beck, and Wade H. Powell

Aryl Hydrocarbon Receptors in the Frog Xenopus laevis: Two AhR1 Paralogs Exhibit Low Affinity for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
ToxSci Advance Access published on June 15, 2005
Toxicol. Sci. 2005 88: 60-72; doi:10.1093/toxsci/kfi228 [Abstract] [Full Text] [PDF] [Request Permissions]  

Xuejun J. Yin, Caroline C. Dong, Jane Y. C. Ma, James M. Antonini, Jenny R. Roberts, Mark W. Barger, and Joseph K. H. Ma

Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte–Mediated Immune Responses Against Listeria monocytogenes
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 73-81; doi:10.1093/toxsci/kfi279 [Abstract] [Full Text] [PDF] [Request Permissions]  

Carolyn J. Broccardo, Ruth E. Billings, Melvin E. Andersen, and William H. Hanneman

Probing the Control Elements of the CYP1A1 Switching Module in H4IIE Hepatoma Cells
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 82-94; doi:10.1093/toxsci/kfi271 [Abstract] [Full Text] [PDF] [Request Permissions]  

Matthew J. Campen, N. Sathish Babu, G. Andrew Helms, Stuart Pett, Jorge Wernly, Reza Mehran, and Jacob D. McDonald

Nonparticulate Components of Diesel Exhaust Promote Constriction in Coronary Arteries from ApoE^–/– Mice
ToxSci Advance Access published on August 10, 2005
Toxicol. Sci. 2005 88: 95-102; doi:10.1093/toxsci/kfi283 [Abstract] [Full Text] [PDF] [Request Permissions]  

Errol Thomson, Prem Kumarathasan, Patrick Goegan, Rémy A. Aubin, and Renaud Vincent

Differential Regulation of the Lung Endothelin System by Urban Particulate Matter and Ozone
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 103-113; doi:10.1093/toxsci/kfi272 [Abstract] [Full Text] [PDF] [Request Permissions]  

Hiromasa Ooe, Takahiro Taira, Sanae M. M. Iguchi-Ariga, and Hiroyoshi Ariga

Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1
ToxSci Advance Access published on August 10, 2005
Toxicol. Sci. 2005 88: 114-126; doi:10.1093/toxsci/kfi278 [Abstract] [Full Text] [PDF] [Request Permissions]  

J. M. Sanders, L. T. Burka, C. S. Smith, W. Black, R. James, and M. L. Cunningham

Differential Expression of CYP1A, 2B, and 3A Genes in the F344 Rat following Exposure to a Polybrominated Diphenyl Ether Mixture or Individual Components
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 127-133; doi:10.1093/toxsci/kfi288 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Andrea W. Sassen, Elmar Richter, Marzell P. Semmler, Ulrich A. Harréus, Fernando Gamarra, and Norbert H. Kleinsasser

Genotoxicity of Nicotine in Mini-Organ Cultures of Human Upper Aerodigestive Tract Epithelia
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 134-141; doi:10.1093/toxsci/kfi297 [Abstract] [Full Text] [PDF] [Request Permissions]  

Nan Mei, Qingsu Xia, Ling Chen, Martha M. Moore, Peter P. Fu, and Tao Chen

Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 142-149; doi:10.1093/toxsci/kfi291 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Caroline C. Dong, Xuejun J. Yin, Jane Y. C. Ma, Lyndell Millecchia, Mark W. Barger, Jenny R. Roberts, Xing-Dong Zhang, James M. Antonini, and Joseph K. H. Ma

Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin (OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuates OVA-Induced Airway Inflammation
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 150-160; doi:10.1093/toxsci/kfi298 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Stephanie Padilla, Renée S. Marshall, Deborah L. Hunter, Sharon Oxendine, Virginia C. Moser, Stanley B. Southerland, and Richard B. Mailman

Neurochemical Effects of Chronic Dietary and Repeated High-Level Acute Exposure to Chlorpyrifos in Rats
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 161-171; doi:10.1093/toxsci/kfi274 [Abstract] [Full Text] [PDF] [Request Permissions]  

Caitlin Dufault, Gabriela Poles, and Lori L. Driscoll

Brief Postnatal PBDE Exposure Alters Learning and the Cholinergic Modulation of Attention in Rats
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 172-180; doi:10.1093/toxsci/kfi285 [Abstract] [Full Text] [PDF] [Request Permissions]  

Prasada Rao S. Kodavanti, Thomas R. Ward, Gabriele Ludewig, Larry W. Robertson, and Linda S. Birnbaum

Polybrominated Diphenyl Ether (PBDE) Effects in Rat Neuronal Cultures: ¹⁴C-PBDE Accumulation, Biological Effects, and Structure-Activity Relationships
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 181-192; doi:10.1093/toxsci/kfi289 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jason R. Richardson, Yu Quan, Todd B. Sherer, J. Timothy Greenamyre, and Gary W. Miller

Paraquat Neurotoxicity is Distinct from that of MPTP and Rotenone
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 193-201; doi:10.1093/toxsci/kfi304 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Caroline C. Dong, Xuejun J. Yin, Jane Y. C. Ma, Lyndell Millecchia, Zhong-Xin Wu, Mark W. Barger, Jenny R. Roberts, James M. Antonini, Richard D. Dey, and Joseph K. H. Ma

Effect of Diesel Exhaust Particles on Allergic Reactions and Airway Responsiveness in Ovalbumin-Sensitized Brown Norway Rats
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 202-212; doi:10.1093/toxsci/kfi280 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Kimberly P. Miller, Rupesh K. Gupta, Chuck R. Greenfeld, Janice K. Babus, and Jodi A. Flaws

Methoxychlor Directly Affects Ovarian Antral Follicle Growth and Atresia through Bcl-2- and Bax-Mediated Pathways
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 213-221; doi:10.1093/toxsci/kfi276 [Abstract] [Full Text] [PDF] [Request Permissions]  

Kelly Brant and Rita Loch Caruso

Late-Gestation Rat Myometrial Cells Express Multiple Isoforms of Phospholipase A₂ That Mediate PCB 50-Induced Release of Arachidonic Acid with Coincident Prostaglandin Production
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 222-230; doi:10.1093/toxsci/kfi296 [Abstract] [Full Text] [PDF] [Request Permissions]  

E. A. Thackaberry, Z. Jiang, C. D. Johnson, K. S. Ramos, and M. K. Walker

Toxicogenomic Profile of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Murine Fetal Heart: Modulation of Cell Cycle and Extracellular Matrix Genes
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 231-241; doi:10.1093/toxsci/kfi301 [Abstract] [Full Text] [PDF] [Request Permissions]  

E. A. Thackaberry, B. A. Nunez, I. D. Ivnitski-Steele, M. Friggins, and M. K. Walker

Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Murine Heart Development: Alteration in Fetal and Postnatal Cardiac Growth, and Postnatal Cardiac Chronotropy
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 242-249; doi:10.1093/toxsci/kfi302 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Neal F. Cariello, Elizabeth H. Romach, Heidi M. Colton, Hong Ni, Lawrence Yoon, J. Greg Falls, Warren Casey, Donald Creech, Steven P. Anderson, Gina R. Benavides, Debie J. Hoivik, Roger Brown, and Richard T. Miller

Gene Expression Profiling of the PPAR-alpha Agonist Ciprofibrate in the Cynomolgus Monkey Liver
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 250-264; doi:10.1093/toxsci/kfi273 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

SYSTEMS TOXICOLOGY:

Amie K. Lund, Steven L. Peterson, Graham S. Timmins, and Mary K. Walker

Endothelin-1–Mediated Increase in Reactive Oxygen Species and NADPH Oxidase Activity in Hearts of Aryl Hydrocarbon Receptor (AhR) Null Mice
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 265-273; doi:10.1093/toxsci/kfi284 [Abstract] [Full Text] [PDF] [Request Permissions]  

David C. McMillan, Christine L. Powell, Zachary S. Bowman, Jason D. Morrow, and David J. Jollow

Lipids versus Proteins as Major Targets of Pro-Oxidant, Direct-Acting Hemolytic Agents
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 274-283; doi:10.1093/toxsci/kfi290 [Abstract] [Full Text] [PDF] [Request Permissions]  

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