Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Maria Pilar Vinardell

In Vitro Cytotoxicity of Nanoparticles in Mammalian Germ-Line Stem Cell
Toxicol. Sci. 2005 88: 285-286; doi:10.1093/toxsci/kfi340 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

C. Gennings, W. H. Carter, Jr., R. A. Carchman, L. K. Teuschler, J. E. Simmons, and E. W. Carney

A Unifying Concept for Assessing Toxicological Interactions: Changes in Slope
ToxSci Advance Access published on August 4, 2005
Toxicol. Sci. 2005 88: 287-297; doi:10.1093/toxsci/kfi275 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

David M. Balshaw, Martin Philbert, and William A. Suk

Research Strategies for Safety Evaluation of Nanomaterials, Part III: Nanoscale Technologies for Assessing Risk and Improving Public Health
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 298-306; doi:10.1093/toxsci/kfi312 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Karluss Thomas, Gary Bannon, Susan Hefle, Corinne Herouet, Michael Holsapple, Gregory Ladics, Sue MacIntosh, and Laura Privalle

In Silico Methods for Evaluating Human Allergenicity to Novel Proteins: International Bioinformatics Workshop Meeting Report, 23–24 February 2005
ToxSci Advance Access published on August 17, 2005
Toxicol. Sci. 2005 88: 307-310; doi:10.1093/toxsci/kfi277 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Burhan I. Ghanayem, L. Patrice McDaniel, Mona I. Churchwell, Nathan C. Twaddle, Rodney Snyder, Timothy R. Fennell, and Daniel R. Doerge

Role of CYP2E1 in the Epoxidation of Acrylamide to Glycidamide and Formation of DNA and Hemoglobin Adducts
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 311-318; doi:10.1093/toxsci/kfi307 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Susan C. Tilton, Lena G. Gerwick, Jerry D. Hendricks, Caprice S. Rosato, Graham Corley-Smith, Scott A. Givan, George S. Bailey, Christopher J. Bayne, and David E. Williams

Use of a Rainbow Trout Oligonucleotide Microarray to Determine Transcriptional Patterns in Aflatoxin B₁-Induced Hepatocellular Carcinoma Compared to Adjacent Liver
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 319-330; doi:10.1093/toxsci/kfi309 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Todd M. Kolb, Ling Duan, and Myrtle A. Davis

Tsc2 Expression Increases the Susceptibility of Renal Tumor Cells to Apoptosis
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 331-339; doi:10.1093/toxsci/kfi310 [Abstract] [Full Text] [PDF] [Request Permissions]  

Anika Bissahoyo, R. Scott Pearsall, Kathleen Hanlon, Vicky Amann, Donna Hicks, Virginia L. Godfrey, and David W. Threadgill

Azoxymethane Is a Genetic Background-Dependent Colorectal Tumor Initiator and Promoter in Mice: Effects of Dose, Route, and Diet
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 340-345; doi:10.1093/toxsci/kfi313 [Abstract] [Full Text] [PDF] [Request Permissions]  

Isabelle Plante, Daniel G. Cyr, and Michel Charbonneau

Involvement of the Integrin-Linked Kinase Pathway in Hexachlorobenzene-Induced Gender-Specific Rat Hepatocarcinogenesis
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 346-357; doi:10.1093/toxsci/kfi323 [Abstract] [Full Text] [PDF] [Request Permissions]  

Tamara Musafia-Jeknic, Brinda Mahadevan, Clifford Pereira, and William M. Baird

Long-Term Effects of a Standardized Complex Mixture of Urban Dust Particulate on the Metabolic Activation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Human Cells in Culture
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 358-366; doi:10.1093/toxsci/kfi329 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

Shin-ichiro Sugiyama, Naoyuki Shimada, Hiroyuki Miyoshi, and Kiyoshi Yamauchi

Detection of Thyroid System–Disrupting Chemicals Using in Vitro and in Vivo Screening Assays in Xenopus laevis
ToxSci Advance Access published on September 22, 2005
Toxicol. Sci. 2005 88: 367-374; doi:10.1093/toxsci/kfi330 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Kim J. Fernie, J. Laird Shutt, Greg Mayne, David Hoffman, Robert J. Letcher, Ken G. Drouillard, and Ian J. Ritchie

Exposure to Polybrominated Diphenyl Ethers (PBDEs): Changes in Thyroid, Vitamin A, Glutathione Homeostasis, and Oxidative Stress in American Kestrels (Falco sparverius)
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2005 88: 375-383; doi:10.1093/toxsci/kfi295 [Abstract] [Full Text] [PDF] [Request Permissions]  

Michio X. Watanabe, Hisato Iwata, Mio Okamoto, Eun-Young Kim, Kumiko Yoneda, Takuma Hashimoto, and Shinsuke Tanabe

Induction of Cytochrome P450 1A5 mRNA, Protein and Enzymatic Activities by Dioxin-Like Compounds, and Congener-Specific Metabolism and Sequestration in the Liver of Wild Jungle Crow (Corvus macrorhynchos) from Tokyo, Japan
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 384-399; doi:10.1093/toxsci/kfi326 [Abstract] [Full Text] [PDF] [Request Permissions]  

Paul J. Kostyniak, Larry G. Hansen, John J. Widholm, Rich D. Fitzpatrick, James R. Olson, Jennifer L. Helferich, Kyung Ho Kim, Helen J. K. Sable, Rich F. Seegal, Isaac N. Pessah, and Susan L. Schantz

Formulation and Characterization of an Experimental PCB Mixture Designed to Mimic Human Exposure from Contaminated Fish
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 400-411; doi:10.1093/toxsci/kfi338 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Laura Braydich-Stolle, Saber Hussain, John J. Schlager, and Marie-Claude Hofmann

In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cells
ToxSci Advance Access published on July 13, 2005
Toxicol. Sci. 2005 88: 412-419; doi:10.1093/toxsci/kfi256 [Abstract] [Full Text] [PDF] [Request Permissions]  

Amy L. Greene, Mark S. Rutherford, Ronald R. Regal, Gail H. Flickinger, Julie A. Hendrickson, Cecilia Giulivi, Margaret E. Mohrman, Daniel G. Fraser, and Jean F. Regal

Arginase Activity Differs with Allergen in the Effector Phase of Ovalbumin- versus Trimellitic Anhydride-Induced Asthma
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 420-433; doi:10.1093/toxsci/kfi311 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

IN VITRO TOXICOLOGY:

Yi Li, Jianzhong Liu, Dahua Pan, and A. J. Hopfinger

A Study of the Relationship between Cornea Permeability and Eye Irritation Using Membrane-Interaction QSAR Analysis
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 434-446; doi:10.1093/toxsci/kfi319 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rocío F. Cantón, J. Thomas Sanderson, Robert J. Letcher, Åke Bergman, and Martin van den Berg

Inhibition and Induction of Aromatase (CYP19) Activity by Brominated Flame Retardants in H295R Human Adrenocortical Carcinoma Cells
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 447-455; doi:10.1093/toxsci/kfi325 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Pere Boadas-Vaello, Judith Riera, and Jordi Llorens

Behavioral and Pathological Effects in the Rat Define Two Groups of Neurotoxic Nitriles
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 456-466; doi:10.1093/toxsci/kfi314 [Abstract] [Full Text] [PDF] [Request Permissions]  

Todd Coffey, Chris Gennings, Jane Ellen Simmons, and David W. Herr

D-Optimal Experimental Designs to Test for Departure from Additivity in a Fixed-Ratio Mixture Ray
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 467-476; doi:10.1093/toxsci/kfi320 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rosa Maria Facciolo, Maria Madeo, Raffaella Alò, Marcello Canonaco, and Francesco Dessì-Fulgheri

Neurobiological Effects of Bisphenol A May Be Mediated by Somatostatin Subtype 3 Receptors in Some Regions of the Developing Rat Brain
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 477-484; doi:10.1093/toxsci/kfi322 [Abstract] [Full Text] [PDF] [Request Permissions]  

Virgília S. Silva, Ana I. Duarte, A. Cristina Rego, Catarina R. Oliveira, and Paula P. Gonçalves

Effect of Chronic Exposure to Aluminium on Isoform Expression and Activity of Rat (Na⁺/K⁺)ATPase
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 485-494; doi:10.1093/toxsci/kfi324 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rosemary A. Schuh, Tibor Kristián, Rupesh K. Gupta, Jodi A. Flaws, and Gary Fiskum

Methoxychlor Inhibits Brain Mitochondrial Respiration and Increases Hydrogen Peroxide Production and CREB Phosphorylation
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 495-504; doi:10.1093/toxsci/kfi334 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Yohannes Tesfaigzi, Jacob D. McDonald, Matthew D. Reed, Shashibhushan P. Singh, George T. De Sanctis, Paul R. Eynott, Fletcher F. Hahn, Matthew J. Campen, and Joe L. Mauderly

Low-Level Subchronic Exposure to Wood Smoke Exacerbates Inflammatory Responses in Allergic Rats
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 505-513; doi:10.1093/toxsci/kfi317 [Abstract] [Full Text] [PDF] [Request Permissions]  

D. B. Warheit, W. J. Brock, K. P. Lee, T. R. Webb, and K. L. Reed

Comparative Pulmonary Toxicity Inhalation and Instillation Studies with Different TiO₂ Particle Formulations: Impact of Surface Treatments on Particle Toxicity
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 514-524; doi:10.1093/toxsci/kfi331 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

De-Xiang Xu, Yuan-Hua Chen, Hua Wang, Lei Zhao, Jian-Ping Wang, and Wei Wei

Effect of N-Acetylcysteine on Lipopolysaccharide-Induced Intra-uterine Fetal Death and Intra-uterine Growth Retardation in Mice
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 525-533; doi:10.1093/toxsci/kfi300 [Abstract] [Full Text] [PDF] [Request Permissions]  

S. A. Myllymäki, T. E. Haavisto, L. J. S. Brokken, M. Viluksela, J. Toppari, and J. Paranko

In Utero and Lactational Exposure to TCDD; Steroidogenic Outcomes Differ in Male and Female Rat Pups
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 534-544; doi:10.1093/toxsci/kfi308 [Abstract] [Full Text] [PDF] [Request Permissions]  

Yuling Mi Caiqiao Zhang

Protective Effect of Quercetin on Aroclor 1254–Induced Oxidative Damage in Cultured Chicken Spermatogonial Cells
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 545-550; doi:10.1093/toxsci/kfi333 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Jennifer L. Seachrist, Cho-Ming Loi, Mark G. Evans, Kay A. Criswell, and Charles E. Rothwell

Roles of Exercise and Pharmacokinetics in Cerivastatin-Induced Skeletal Muscle Toxicity
ToxSci Advance Access published on September 1, 2005
Toxicol. Sci. 2005 88: 551-561; doi:10.1093/toxsci/kfi305 [Abstract] [Full Text] [PDF] [Request Permissions]  

Luis A. Diaz, Jr., Ian Cheong, Catherine A. Foss, Xiaosong Zhang, Brock A. Peters, Nishant Agrawal, Chetan Bettegowda, Baktiar Karim, Guosheng Liu, Khalid Khan, Xin Huang, Manu Kohli, Long H. Dang, Paul Hwang, Ahava Vogelstein, Elizabeth Garrett-Mayer, Barry Kobrin, Martin Pomper, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein, and David L. Huso

Pharmacologic and Toxicologic Evaluation of C. novyi-NT Spores
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 562-575; doi:10.1093/toxsci/kfi316 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

SYSTEMS TOXICOLOGY:

Senait Asmellash, James L. Stevens, and Takaharu Ichimura

Modulating the Endoplasmic Reticulum Stress Response with trans-4,5-Dihydroxy-1,2-Dithiane Prevents Chemically Induced Renal Injury In Vivo
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 576-584; doi:10.1093/toxsci/kfi303 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jennifer Fostel, Danielle Choi, Craig Zwickl, Norman Morrison, Asif Rashid, Atif Hasan, Wenjun Bao, Ann Richard, Weida Tong, Pierre R. Bushel, Roger Brown, Maribel Bruno, Michael L. Cunningham, David Dix, William Eastin, Carlos Frade, Alex Garcia, Alexandra Heinloth, Rick Irwin, Jennifer Madenspacher, B. Alex Merrick, Thomas Papoian, Richard Paules, Philippe Rocca-Serra, Assunta-Susanna Sansone, James Stevens, Kenneth Tomer, Chihae Yang, and Michael Waters

Chemical Effects in Biological Systems—Data Dictionary (CEBS-DD): A Compendium of Terms for the Capture and Integration of Biological Study Design Description, Conventional Phenotypes, and ‘Omics Data
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 585-601; doi:10.1093/toxsci/kfi315 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Wendy Kennette, Olga M. Collins, Rudolfs K. Zalups, and Jim Koropatnick

Basal and Zinc-Induced Metallothionein in Resistance to Cadmium, Cisplatin, Zinc, and tertButyl Hydroperoxide: Studies Using MT Knockout and Antisense-Downregulated MT in Mammalian Cells
ToxSci Advance Access published on September 8, 2005
Toxicol. Sci. 2005 88: 602-613; doi:10.1093/toxsci/kfi318 [Abstract] [Full Text] [PDF] [Request Permissions]  

Alison Elder, Robert Gelein, Jacob N. Finkelstein, Kevin E. Driscoll, Jack Harkema, and Günter Oberdörster

Effects of Subchronically Inhaled Carbon Black in Three Species. I. Retention Kinetics, Lung Inflammation, and Histopathology
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 614-629; doi:10.1093/toxsci/kfi327 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Lawrence H. Lash, Sarah E. Hueni, David A. Putt, and Rudolfs K. Zalups

Role of Organic Anion and Amino Acid Carriers in Transport of Inorganic Mercury in Rat Renal Basolateral Membrane Vesicles: Influence of Compensatory Renal Growth
ToxSci Advance Access published on September 14, 2005
Toxicol. Sci. 2005 88: 630-644; doi:10.1093/toxsci/kfi328 [Abstract] [Full Text] [PDF] [Request Permissions]  

Ih Chu, Wayne J. Bowers, Don Caldwell, Jamie Nakai, Olga Pulido, Al Yagminas, Michael G. Wade, David Moir, Santokh Gill, and Rudi Mueller

Toxicological Effects of Gestational and Lactational Exposure to a Mixture of Persistent Organochlorines in Rats: Systemic Effects
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2005 88: 645-655; doi:10.1093/toxsci/kfi335 [Abstract] [Full Text] [PDF] [Request Permissions]  

CORRECTION:

James F. Dillman, III and Christopher S. Phillips

CORRECTION
Toxicol. Sci. 2005 88: 656; doi:10.1093/toxsci/kfi337 [Extract] [Full Text] [PDF] [Request Permissions]  

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