Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Bellina Veronesi and Marga Oortgiesen

The TRPV1 Receptor: Target of Toxicants and Therapeutics
Toxicol. Sci. 2006 89: 1-3; doi:10.1093/toxsci/kfj034 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW:

Laurie C. Haws, Steave H. Su, Mark Harris, Michael J. DeVito, Nigel J. Walker, William H. Farland, Brent Finley, and Linda S. Birnbaum

Development of a Refined Database of Mammalian Relative Potency Estimates for Dioxin-like Compounds
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2006 89: 4-30; doi:10.1093/toxsci/kfi294 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Hartmut Jaeschke and Mary Lynn Bajt

Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2006 89: 31-41; doi:10.1093/toxsci/kfi336 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES:

Joyce S. Tsuji, Andrew D. Maynard, Paul C. Howard, John T. James, Chiu-wing Lam, David B. Warheit, and Annette B. Santamaria

Research Strategies for Safety Evaluation of Nanomaterials, Part IV: Risk Assessment of Nanoparticles
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2006 89: 42-50; doi:10.1093/toxsci/kfi339 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

Michael P. Holsapple, Henri C. Pitot, Samuel H. Cohen, Alan R. Boobis, James E. Klaunig, Timothy Pastoor, Vicki L. Dellarco, and Yvonne P. Dragan

Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 51-56; doi:10.1093/toxsci/kfj001 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Faisal F. Y. Radwan and John S. Ramsdell

Characterization of In Vitro Oxidative and Conjugative Metabolic Pathways for Brevetoxin (PbTx-2)
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 57-65; doi:10.1093/toxsci/kfj013 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Geoffrey M. Curtin, Margaret Hanausek, Zbigniew Walaszek, Robert Zoltaszek, James E. Swauger, Arnold T. Mosberg, and Thomas J. Slaga

Short-Term Biomarkers of Cigarette Smoke Condensate Tumor Promoting Potential in Mouse Skin
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 66-74; doi:10.1093/toxsci/kfi343 [Abstract] [Full Text] [PDF] [Request Permissions]  

Rushang D. Patel, Dae Joon Kim, Jeffrey M. Peters, and Gary H. Perdew

The Aryl Hydrocarbon Receptor Directly Regulates Expression of the Potent Mitogen Epiregulin
ToxSci Advance Access published on September 28, 2005
Toxicol. Sci. 2006 89: 75-82; doi:10.1093/toxsci/kfi344 [Abstract] [Full Text] [PDF] [Request Permissions]  

Andrea S. Randi, Claudia Cocca, Verónica Carbone, Mariel Nuñez, Máximo Croci, Alicia Gutiérrez, Rosa Bergoc, and Diana L. Kleiman de Pisarev

Hexachlorobenzene Is a Tumor Co-carcinogen and Induces Alterations in Insulin-Growth Factors Signaling Pathway in the Rat Mammary Gland
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 83-92; doi:10.1093/toxsci/kfj023 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Keerthi S. Guruge, Leo W. Y. Yeung, Noriko Yamanaka, Shigeru Miyazaki, Paul K. S. Lam, John P. Giesy, Paul D. Jones, and Nobuyoshi Yamashita

Gene Expression Profiles in Rat Liver Treated With Perfluorooctanoic Acid (PFOA)
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 93-107; doi:10.1093/toxsci/kfj011 [Abstract] [Full Text] [PDF] [Request Permissions]  

Kenneth A. Voss, Jie Liu, Steven P. Anderson, Corrie Dunn, J. David Miller, Joy R. Owen, Ronald T. Riley, Charles W. Bacon, and J. Christopher Corton

Toxic Effects of Fumonisin in Mouse Liver Are Independent of the Peroxisome Proliferator-Activated Receptor
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 108-119; doi:10.1093/toxsci/kfj019 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

GENETIC TOXICOLOGY:

M. Marin-Kuan, S. Nestler, C. Verguet, C. Bezençon, D. Piguet, R. Mansourian, J. Holzwarth, M. Grigorov, T. Delatour, P. Mantle, C. Cavin, and B. Schilter

A Toxicogenomics Approach to Identify New Plausible Epigenetic Mechanisms of Ochratoxin A Carcinogenicity in Rat
ToxSci Advance Access published on October 26, 2005
Toxicol. Sci. 2006 89: 120-134; doi:10.1093/toxsci/kfj017 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Sheung P. Ng, Allen E. Silverstone, Zhi-Wei Lai, and Judith T. Zelikoff

Effects of Prenatal Exposure to Cigarette Smoke on Offspring Tumor Susceptibility and Associated Immune Mechanisms
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 135-144; doi:10.1093/toxsci/kfj006 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stamatina E. Ziemba, Raymond R. Mattingly, Michael J. McCabe, Jr., and Allen J. Rosenspire

Inorganic Mercury Inhibits the Activation of LAT in T-Cell Receptor-Mediated Signal Transduction
ToxSci Advance Access published on October 26, 2005
Toxicol. Sci. 2006 89: 145-153; doi:10.1093/toxsci/kfj029 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Daishiro Miura, Mitsuru Kobayashi, Satoko Kakiuchi, Yoshinori Kasahara, and Shiro Kondo

Enhancement of Transformed Foci and Induction of Prostaglandins in Balb/c 3T3 Cells by Palytoxin: In Vitro Model Reproduces Carcinogenic Responses in Animal Models Regarding the Inhibitory Effect of Indomethacin and Reversal of Indomethacin's Effect by Exogenous Prostaglandins
ToxSci Advance Access published on September 28, 2005
Toxicol. Sci. 2006 89: 154-163; doi:10.1093/toxsci/kfi342 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Ju-Pi Li, Jin-Ching Lin, and Jia-Ling Yang

ERK Activation in Arsenite-Treated G1-Enriched CL3 Cells Contributes to Survival, DNA Repair Inhibition, and Micronucleus Formation
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 164-172; doi:10.1093/toxsci/kfj004 [Abstract] [Full Text] [PDF] [Request Permissions]  

Edwin Sonneveld, Jacoba A. C. Riteco, Hendrina J. Jansen, Bart Pieterse, Abraham Brouwer, Willem G. Schoonen, and Bart van der Burg

Comparison of In Vitro and In Vivo Screening Models for Androgenic and Estrogenic Activities
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 173-187; doi:10.1093/toxsci/kfj009 [Abstract] [Full Text] [PDF] [Request Permissions]  

D. van der Merwe, J. D. Brooks, R. Gehring, R. E. Baynes, N. A. Monteiro-Riviere, and J. E. Riviere

A Physiologically Based Pharmacokinetic Model of Organophosphate Dermal Absorption
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 188-204; doi:10.1093/toxsci/kfj014 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Han Chang, Louis W. Chang, Ya-Hsin Cheng, Wen-Tin Tsai, Ming-Xian Tsai, and Pinpin Lin

Preferential Induction of CYP1A1 and CYP1B1 in CCSP-Positive Cells
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 205-213; doi:10.1093/toxsci/kfj025 [Abstract] [Full Text] [PDF] [Request Permissions]  

Stephen E. Bloom, Ann T. Lemley, and Donna E. Muscarella

Potentiation of Apoptosis by Heat Stress Plus Pesticide Exposure in Stress Resistant Human B-Lymphoma Cells and Its Attenuation through Interaction with Follicular Dendritic Cells: Role for c-Jun N-terminal Kinase Signaling
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 214-223; doi:10.1093/toxsci/kfj021 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Richard M. LoPachin, David S. Barber, Deke He, and Soma Das

Acrylamide Inhibits Dopamine Uptake in Rat Striatal Synaptic Vesicles
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 224-234; doi:10.1093/toxsci/kfj005 [Abstract] [Full Text] [PDF] [Request Permissions]  

Yusuke Nakatsu, Yaichiro Kotake, Kazuya Komasaka, Hiroko Hakozaki, Ryota Taguchi, Toshiaki Kume, Akinori Akaike, and Shigeru Ohta

Glutamate Excitotoxicity Is Involved in Cell Death Caused by Tributyltin in Cultured Rat Cortical Neurons
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 235-242; doi:10.1093/toxsci/kfj007 [Abstract] [Full Text] [PDF] [Request Permissions]  

Shenfeng Qiu, C. Wook Pak, and Margarita C. Currás-Collazo

Sequential Involvement of Distinct Glutamate Receptors in Domoic Acid-Induced Neurotoxicity in Rat Mixed Cortical Cultures: Effect of Multiple Dose/Duration Paradigms, Chronological Age, and Repeated Exposure
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 243-256; doi:10.1093/toxsci/kfj008 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data [Request Permissions]  

G. Giusi, R. M. Facciolo, M. Canonaco, E. Alleva, V. Belloni, F. Dessi'-Fulgheri, and D. Santucci

The Endocrine Disruptor Atrazine Accounts for a Dimorphic Somatostatinergic Neuronal Expression Pattern in Mice
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 257-264; doi:10.1093/toxsci/kfj012 [Abstract] [Full Text] [PDF] [Request Permissions]  

Abdullah Shafique Ahmad, Sofiyan Saleem, Muzamil Ahmad, and Sylvain Doré

Prostaglandin EP1 Receptor Contributes to Excitotoxicity and Focal Ischemic Brain Damage
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 265-270; doi:10.1093/toxsci/kfj022 [Abstract] [Full Text] [PDF] [Request Permissions]  

M. J. Wolansky, C. Gennings, and K. M. Crofton

Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 271-277; doi:10.1093/toxsci/kfj020 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY:

Mark E. Johansen, Christopher A. Reilly, and Garold S. Yost

TRPV1 Antagonists Elevate Cell Surface Populations of Receptor Protein and Exacerbate TRPV1-Mediated Toxicities in Human Lung Epithelial Cells
ToxSci Advance Access published on August 24, 2005
Toxicol. Sci. 2006 89: 278-286; doi:10.1093/toxsci/kfi292 [Abstract] [Full Text] [PDF] [Request Permissions]  

Marjorie Monleau, Michel De Méo, François Paquet, Valérie Chazel, Gérard Duménil, and Marie Donnadieu-Claraz

Genotoxic and Inflammatory Effects of Depleted Uranium Particles Inhaled by Rats
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 287-295; doi:10.1093/toxsci/kfj010 [Abstract] [Full Text] [PDF] [Request Permissions]  

D. B. Warheit, K. L. Reed, J. D. Stonehuerner, A. J. Ghio, and T. R. Webb

Biodegradability of Para-aramid Respirable-Sized Fiber-Shaped Particulates (RFP) in Human Lung Cells
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 296-303; doi:10.1093/toxsci/kfj028 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Michael G. Wade, Raymond Poon, Nanqin Li, Alice Lee, Avril McMahon, and Ih Chu

Testicular Toxicity of Candidate Fuel Additive 1,6-Dimethoxyhexane: Comparison with Several Similar Aliphatic Ethers
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 304-313; doi:10.1093/toxsci/kfj002 [Abstract] [Full Text] [PDF] [Request Permissions]  

L. E. Paraoanu, J. B. Mocko, M. Becker-Roeck, J. Smidek-Huhn, and P. G. Layer

Exposure to Diazinon Alters In Vitro Retinogenesis: Retinospheroid Morphology, Development of Chicken Retinal Cell Types, and Gene Expression
ToxSci Advance Access published on October 5, 2005
Toxicol. Sci. 2006 89: 314-324; doi:10.1093/toxsci/kfj003 [Abstract] [Full Text] [PDF] [Request Permissions]  

N. M. Weber, H. R. Sawyer, M. E. Legare, and D. N. R. Veeramachaneni

Sub-chronic Exposure to Dibromoacetic Acid, a Water Disinfection By-product, Does Not Affect Gametogenic Potential in Mice
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 325-330; doi:10.1093/toxsci/kfj015 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT:

Melvin E. Andersen, Roman W. Lutz, Kai H. Liao, and Werner K. Lutz

Dose-Incidence Modeling: Consequences of Linking Quantal Measures of Response to Depletion of Critical Tissue Targets
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 331-337; doi:10.1093/toxsci/kfj024 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION:

Jun Sung Kim, Tae-Jong Yoon, Kyeong Nam Yu, Byung Gul Kim, Sung Jin Park, Hyun Woo Kim, Kee Ho Lee, Seung Bum Park, Jin-Kyu Lee, and Myung Haing Cho

Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice
ToxSci Advance Access published on October 19, 2005
Toxicol. Sci. 2006 89: 338-347; doi:10.1093/toxsci/kfj027 [Abstract] [Full Text] [PDF] [Request Permissions]  

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