Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT:

Philip C. Burcham

Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity
Toxicol. Sci. 2006 89: 349-351; doi:10.1093/toxsci/kfj059 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW AND COMMENT:

Darrell R. Boverhof and Timothy R. Zacharewski

Toxicogenomics in Risk Assessment: Applications and Needs
ToxSci Advance Access published on October 12, 2005
Toxicol. Sci. 2006 89: 352-360; doi:10.1093/toxsci/kfj018 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM:

James A. Popp, Edmund Crouch, and Ernest E. McConnell

A Weight-of-Evidence Analysis of the Cancer Dose-Response Characteristics of 2,3,7,8-Tetrachlorodibenzodioxin (TCDD)
ToxSci Advance Access published on November 2, 2005
Toxicol. Sci. 2006 89: 361-369; doi:10.1093/toxsci/kfj016 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS:

Lauren M. Aleksunes, George L. Scheffer, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, and José E. Manautou

Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury
ToxSci Advance Access published on September 21, 2005
Toxicol. Sci. 2006 89: 370-379; doi:10.1093/toxsci/kfi332 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

D. F. Staskal, J. J. Diliberto, and L. S. Birnbaum

Impact of Repeated Exposure on the Toxicokinetics of BDE 47 in Mice
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 380-385; doi:10.1093/toxsci/kfj038 [Abstract] [Full Text] [PDF] [Request Permissions]  

Miyoung Yoon, Michael C. Madden, and Hugh A. Barton

Developmental Expression of Aldehyde Dehydrogenase in Rat: a Comparison of Liver and Lung Development
ToxSci Advance Access published on November 16, 2005
Toxicol. Sci. 2006 89: 386-398; doi:10.1093/toxsci/kfj045 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY:

Terry R. Van Vleet, Todd L. Watterson, Patrick J. Klein, and Roger A. Coulombe, Jr.

Aflatoxin B₁ Alters the Expression of p53 in Cytochrome P450-Expressing Human Lung Cells
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 399-407; doi:10.1093/toxsci/kfj039 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY:

P. Pocar, T. Klonisch, C. Brandsch, K. Eder, C. Fröhlich, C. Hoang-Vu, and S. Hombach-Klonisch

AhR-Agonist-Induced Transcriptional Changes of Genes Involved in Thyroid Function in Primary Porcine Thyrocytes
ToxSci Advance Access published on November 16, 2005
Toxicol. Sci. 2006 89: 408-414; doi:10.1093/toxsci/kfj042 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY:

Brian E. Powers, John J. Widholm, Robert E. Lasky, and Susan L. Schantz

Auditory Deficits in Rats Exposed to an Environmental PCB Mixture during Development
ToxSci Advance Access published on November 29, 2005
Toxicol. Sci. 2006 89: 415-422; doi:10.1093/toxsci/kfj051 [Abstract] [Full Text] [PDF] [Request Permissions]  

Biing-Hui Liu, Ting-Shuan Wu, Feng-Yih Yu, and Chun-Hui Wang

Mycotoxin Patulin Activates the p38 Kinase and JNK Signaling Pathways in Human Embryonic Kidney Cells
ToxSci Advance Access published on November 23, 2005
Toxicol. Sci. 2006 89: 423-430; doi:10.1093/toxsci/kfj049 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY:

Sarmishtha Chanda, Uma B. Dasgupta, Debendranath GuhaMazumder, Mausumi Gupta, Utpal Chaudhuri, Sarbari Lahiri, Subhankar Das, Nilima Ghosh, and Debdutta Chatterjee

DNA Hypermethylation of Promoter of Gene p53 and p16 in Arsenic-Exposed People with and without Malignancy
ToxSci Advance Access published on October 26, 2005
Toxicol. Sci. 2006 89: 431-437; doi:10.1093/toxsci/kfj030 [Abstract] [Full Text] [PDF] [Request Permissions]  

Jie Ping, Hui Wang, Min Huang, and Zhi-su Liu

Genetic Analysis of Glutathione S-transferase A1 Polymorphism in the Chinese Population and the Influence of Genotype on Enzymatic Properties
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 438-443; doi:10.1093/toxsci/kfj037 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXIOCOLOGY:

Donghong Gao, Jane Kasten-Jolly, and David A. Lawrence

The Paradoxical Effects of Lead in Interferon-Gamma Knockout BALB/c Mice
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 444-453; doi:10.1093/toxsci/kfj043 [Abstract] [Full Text] [PDF] [Request Permissions]  

Christine P. Curran, Kevin A. Miller, Timothy P. Dalton, Charles V. Vorhees, Marian L. Miller, Howard G. Shertzer, and Daniel W. Nebert

Genetic Differences in Lethality of Newborn Mice Treated In Utero with Coplanar versus Non-Coplanar Hexabromobiphenyl
ToxSci Advance Access published on November 16, 2005
Toxicol. Sci. 2006 89: 454-464; doi:10.1093/toxsci/kfj048 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY:

Margarita D. Apostolova, Tania Christova, and Douglas M. Templeton

Involvement of Gelsolin in Cadmium-Induced Disruption of the Mesangial Cell Cytoskeleton
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 465-474; doi:10.1093/toxsci/kfj035 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY:

Jaspreet S. Sidhu, Rafael A. Ponce, Melinda A. Vredevoogd, Xiaozhong Yu, Elizabeth Gribble, Sung-Woo Hong, Emily Schneider, and Elaine M. Faustman

Cell Cycle Inhibition by Sodium Arsenite in Primary Embryonic Rat Midbrain Neuroepithelial Cells
ToxSci Advance Access published on October 26, 2005
Toxicol. Sci. 2006 89: 475-484; doi:10.1093/toxsci/kfj032 [Abstract] [Full Text] [PDF] [Request Permissions]  

Holly L. Valentine, Kalyani Amarnath, Venkataraman Amarnath, and William M. Valentine

Dietary Copper Enhances the Peripheral Myelinopathy Produced by Oral Pyrrolidine Dithiocarbamate
ToxSci Advance Access published on November 16, 2005
Toxicol. Sci. 2006 89: 485-494; doi:10.1093/toxsci/kfj047 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY:

Joslynn G. Affleck, Katerina Neumann, Lily Wong, and Virginia K. Walker

The Effects of Methotrexate on Drosophila Development, Female Fecundity, and Gene Expression
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 495-503; doi:10.1093/toxsci/kfj036 [Abstract] [Full Text] [PDF] [Request Permissions]  

Zengli Yu, Jing Han, Jiuxiang Lin, Ying Xiao, Xingzhong Zhang, and Yong Li

Apoptosis Induced by atRA in MEPM Cells Is Mediated through Activation of Caspase and RAR
ToxSci Advance Access published on November 16, 2005
Toxicol. Sci. 2006 89: 504-509; doi:10.1093/toxsci/kfj046 [Abstract] [Full Text] [PDF] [Request Permissions]  

Daniel A. Symonds, Kimberly P. Miller, Dragana Tomic, and Jodi A. Flaws

Effect of Methoxychlor and Estradiol on Cytochrome P450 Enzymes in the Mouse Ovarian Surface Epithelium
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 510-514; doi:10.1093/toxsci/kfj044 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY:

Yongke Lu and Arthur I. Cederbaum

Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1
ToxSci Advance Access published on October 26, 2005
Toxicol. Sci. 2006 89: 515-523; doi:10.1093/toxsci/kfj031 [Abstract] [Full Text] [PDF] [Request Permissions]  

David C. Volz, David E. Hinton, J. McHugh Law, and Seth W. Kullman

Dynamic Gene Expression Changes Precede Dioxin-Induced Liver Pathogenesis in Medaka Fish
ToxSci Advance Access published on November 2, 2005
Toxicol. Sci. 2006 89: 524-534; doi:10.1093/toxsci/kfj033 [Abstract] [Full Text] [PDF] Supplementary Data [Request Permissions]  

Joshua P. Gray, John W. Davis, II, Lakshmi Gopinathan, Tara L. Leas, Courtney A. Nugent, and John P. Vanden Heuvel

The Ribosomal Protein rpL11 Associates with and Inhibits the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor-
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 535-546; doi:10.1093/toxsci/kfj040 [Abstract] [Full Text] [PDF] [Request Permissions]  

Pramod Kumar Avti, Surender Kumar, Chander Mohan Pathak, Kim Vaiphei, and Krishan Lal Khanduja

Smokeless Tobacco Impairs the Antioxidant Defense in Liver, Lung, and Kidney of Rats
ToxSci Advance Access published on November 9, 2005
Toxicol. Sci. 2006 89: 547-553; doi:10.1093/toxsci/kfj041 [Abstract] [Full Text] [PDF] [Request Permissions]  

ERRATA:

ERRATUM
Toxicol. Sci. 2006 89: 554; doi:10.1093/toxsci/kfj050 [Extract] [Full Text] [PDF] [Request Permissions]  

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